Gene Page:CDH2

Summary？
基因 1000
象征 CDH2
Synonyms CD325 | CDHN | CDW325 | NCAD
Description 钙粘蛋白2
Reference MIM:114020|HGNC：HGNC：1759|Ensembl:ENSG00000170558|HPRD:00226|Vega：Otthumg00000059940
基因类型 蛋白质编码
Map location 18q11.2
Pascal p-value 0.97
Sherlock p-value 0.539
胎儿β 0.8
DMG 1(# studies)
主持人 元
Support CELL ADHESION AND TRANSSYNAPTIC SIGNALING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS
G2CDB.HUMANNRC
CompositeSet
Ascano FMRP targets
潜在的突触基因

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp Genome-wide Association Study GWAS
DMG：JAFFE_2016 全基因组DNA甲基化分析 This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：0.3081

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
cg15698842 18 25755641 CDH2 3.92E-8 -0.023 1.11E-5 DMG：JAFFE_2016


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CNTNAP2 0.68 0.83
rab3c 0.67 0.82
GPR137C 0.65 0.67
PGM2L1 0.63 0.69
yaf2 0.62 0.70
TCERG1L 0.62 0.72
EMID2 0.62 0.67
TBC1D9 0.62 0.73
RASGEF1B 0.62 0.65
plekhb2 0.62 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GPRC5C -0.37 -0.43
EFEMP2 -0.36 -0.42
EIF4EBP3 -0.35 -0.38
AQP5 -0.34 -0.38
FXYD1 -0.33 -0.30
MT-CO2 -0.32 -0.35
rom1 -0.32 -0.30
AF347015.2 -0.32 -0.30
AF347015.26 -0.32 -0.29
AF347015.31 -0.32 -0.33

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005509 calcium ion binding IEA -
去：0005515 蛋白质结合 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0007155 cell adhesion TAS 2384753
GO:0007156 同粒细胞粘附 IEA -
GO：0016339 calcium-dependent cell-cell adhesion IEA -
GO：0016477 cell migration IEA -
GO:0048514 blood vessel morphogenesis IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0045202 突触 IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO：0016021 膜不可或缺 IEA -
GO:0030027 lamellipodium IEA -
GO:0005912 adherens junction IEA -
去：0005886 plasma membrane IEA -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
ACTA1 Acta |Asma |CFTD |CFTD1 |CFTDM |mpfd |Nem1 |Nem2 |NEM3 actin, alpha 1, skeletal muscle 亲和力捕获 - 韦斯特恩 Biogrid 12438242
ARVCF FLJ35345 armadillo repeat gene deletes in velocardiofacial syndrome - HPRD 11058098
boc - Boc homolog (mouse) - HPRD,BioGRID 12634428
CDH11 CAD11 | CDHOB | OB | OSF-4 cadherin 11, type 2, OB-cadherin (osteoblast) - HPRD,BioGRID 14625392
CDH4 cad4 |FLJ22202 |FLJ40547 |MGC126700 |MGC138355 |rcad cadherin 4, type 1, R-cadherin (retinal) - HPRD,BioGRID 10662782
CDON CDO |MGC111524 |Orcam Cdon homolog (mouse) - HPRD,BioGRID 12634428
CTNNA1 CAP102 |FLJ36832 catenin (cadherin-associated protein), alpha 1, 102kDa Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 12604612|14625392
CTNNB1 ctnnb |DKFZP686D02253 |FLJ25606 |FLJ37923 Catenin（cadherin相关蛋白），β1，88KDA Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 12604612|14625392
CTNNB1 ctnnb |DKFZP686D02253 |FLJ25606 |FLJ37923 Catenin（cadherin相关蛋白），β1，88KDA - HPRD 12151522
ctnnd1 CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120 catenin (cadherin-associated protein), delta 1 Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 12604612|14625392
GNA12 MGC104623 | MGC99644 | NNX3 | RMP | gep guanine nucleotide binding protein (G protein) alpha 12 - HPRD,BioGRID 11136230
GNA13 G13 | MGC46138 guanine nucleotide binding protein (G protein), alpha 13 - HPRD,BioGRID 11136230
GRIK2 EAA4 |Glr6 |Gluk6 |glur6 |MGC74427 |MRT6 谷氨酸受体,ionotropic kainate 2 - HPRD 12151522
GRIN1 NMDA1 | NMDAR1 | NR1 谷氨酸受体，离子型，N-甲基D-天冬氨酸1 - HPRD 10862698
JUP ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB 交界处Plakoglobin - HPRD 1639850
JUP ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB 交界处Plakoglobin Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 7650039|14625392
LRRC7 DKFZP686I1147 |KIAA1365 |MGC144918 含亮氨酸丰富的重复含有7 - HPRD,BioGRID 11729199
PKP4 FLJ31261 |FLJ42243 |P0071 plakophilin 4 Two-hybrid Biogrid 12615965
PTPN1 ptp1b 蛋白质酪氨酸磷酸酶，非受体1型 - HPRD 12377785
RAB8B FLJ38125 Rab8b，Ras Oncogene家族成员 亲和力捕获 - 韦斯特恩 Biogrid 12639940
RICS GC-GAP |砂砾|KIAA0712 |MGC1892 |P200RHOGAP |P250GAP Rho GTPase激活蛋白 - HPRD 12531901


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg细胞粘附分子凸轮 134 93 All SZGR 2.0 genes in this pathway
KEGG心律失常右心肌病ARVC 76 59 All SZGR 2.0 genes in this pathway
PID PTP1B途径 52 40 All SZGR 2.0 genes in this pathway
pid ajdiss 2Pathway 48 38 All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY 33 32 All SZGR 2.0 genes in this pathway
PID FGF途径 55 37 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 120 77 All SZGR 2.0 genes in this pathway
Reactome Adherens连接相互作用 27 20 All SZGR 2.0 genes in this pathway
Reactome细胞连接组织 56 31 All SZGR 2.0 genes in this pathway
Reactome细胞连接组织 78 43 All SZGR 2.0 genes in this pathway
反应组肌发生 28 20 All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血祖先DN 66 42 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
Bogni治疗与髓样白血病DN有关 33 19 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214 155 All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性 722 443 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 85 57 All SZGR 2.0 genes in this pathway
甲状腺癌 443 294 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186 107 All SZGR 2.0 genes in this pathway
高山被AR约束 10 6 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
Li Cisplatin抗性 28 20 All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 62 33 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN 514 319 All SZGR 2.0 genes in this pathway
瓦特自动甲状腺腺瘤 73 47 All SZGR 2.0 genes in this pathway
小钙虹膜虹膜素敏感与抗性DN 5 5 All SZGR 2.0 genes in this pathway
Karakas TGFB1信号传导 18 15 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时DN 428 306 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP 69 55 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
Benporath SOX2目标 734 436 All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上 256 159 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 71 51 All SZGR 2.0 genes in this pathway
马纳洛缺氧 207 145 All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244 154 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162 102 All SZGR 2.0 genes in this pathway
康（Kang）由tert dn永生 102 67 All SZGR 2.0 genes in this pathway
Petrova Prox1靶向DN 64 38 All SZGR 2.0 genes in this pathway
McClung Delta FOSB目标8WK 47 38 All SZGR 2.0 genes in this pathway
HNE和H2O2的Weigel氧化应激 39 29 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL 35 25 All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 51 41 All SZGR 2.0 genes in this pathway
Kaab心脏中心与心室DN 261 183 All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT LATE UP 22 16 All SZGR 2.0 genes in this pathway
外邦紫外线低剂量DN 67 46 All SZGR 2.0 genes in this pathway
CLASPER LYMPHATIC VESSELS DURING METASTASIS DN 36 23 All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛 299 167 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
NADELLA PRKAR1A TARGETS DN 8 8 All SZGR 2.0 genes in this pathway
Smid乳腺癌基础 648 398 All SZGR 2.0 genes in this pathway
bocHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜 425 298 All SZGR 2.0 genes in this pathway
TGFB1和WNT3A的LABBE目标 111 70 All SZGR 2.0 genes in this pathway
西肾上腺皮质肿瘤DN 546 362 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS EMT UP 36 24 All SZGR 2.0 genes in this pathway
阿隆索转移 198 128 All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP 46 28 All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C D DN 252 155 All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS 80 56 All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 71 49 All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟D 68 44 All SZGR 2.0 genes in this pathway
Hinata NFKB靶向成纤维细胞 84 60 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
由MYC DN监管 253 192 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向 504 321 All SZGR 2.0 genes in this pathway
pasini suz12靶向DN 315 215 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
Abdelmohsen Elavl4目标 16 13 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-124/506 239 245 M8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-129-5p 976 982 1A HSA-MIR-129brain cuuuuugcgguggggcuugc
HSA-MIR-129-5p cuuuuugcgguggggcuugcu
miR-144 170 176 M8 HSA-MIR-144 UACAGUAUAGAUGAUGUACUAG
miR-190 580 586 1A HSA-MIR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-194 382 388 1A HSA-MIR-194 uguaacagcaacuccauga
mir-204/211 568 574 M8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
mir-208 642 648 1A hsa-miR-208 auaagacgaaaaaagcuugu
mir-218 949 955 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
mir-221/222 593 599 1A hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain agcuacaucuggcuacugggucuc
miR-26 202 208 1A HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
mir-320 1101 1107 M8 hsa-miR-320 aaaagcugggugagaggggcgaa
mir-338 109 115 1A hsa-miR-338brain uccagauuuuuguuga
mir-369-3p 766 772 M8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-493-5p 484 490 M8 HSA-MIR-493-5p uuguacaugguaggcuuucauu
HSA-MIR-493-5p uuguacaugguaggcuuucauu
miR-495 380 386 1A HSA-MIR-495brain Aaacaaacauggugcacuuuuu
miR-499 642 648 1A HSA-MIR-499 UUAAGACUUGCAGUGAUGUUUAA
mir-543 623 630 1A，M8 hsa-miR-543 aaacauucgcggugcacuucu