Gene Page:BCL2L11

Summary？
基因 10018
象征 BCL2L11
Synonyms bam | bim | bod
Description Bcl2像11
Reference MIM：603827|HGNC:HGNC:994|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256
基因类型 蛋白质编码
Map location 2Q13
Pascal p-value 0.029
胎儿β 0.668
主持人 Cerebellar Hemisphere
小脑

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_I Genome scan meta-analysis PSR：0.0004
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00755
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
IQGAP1 0.81 0.76
WWC3 0.81 0.81
C1orf198 0.81 0.83
NDE1 0.80 0.75
WDFY2 0.80 0.79
phlpp1 0.79 0.78
flnb 0.79 0.83
sall1 0.79 0.80
CTNNA1 0.79 0.76
FUBP3 0.78 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
TTC9B -0.43 -0.46
Sycp3 -0.42 -0.39
ST20 -0.39 -0.43
AC044839.2 -0.39 -0.32
USMG5 -0.39 -0.45
UQCR -0.39 -0.41
UQCRQ -0.39 -0.41
ZFAND2A -0.39 -0.41
CARD16 -0.38 -0.38
Rergl -0.38 -0.36

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IPI 10198631|15694340|16282323
|17692808
GO:0008017 微管结合 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0007160 cell-matrix adhesion IEA -
GO:0006917 诱导凋亡 TAS 10381623
去：0008633 促凋亡基因产物的激活 经验 14764673
GO：0030879 乳腺发育 IEA -
GO：0035148 lumen formation IEA -
去：0046620 regulation of organ growth IEA -
GO：0048563 胚胎后器官形态发生 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0005829 细胞质 经验 12591950
去：0005624 membrane fraction TAS 9430630
去：0005741 线粒体外膜 经验 10198631
去：0005886 plasma membrane 经验 12591950

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
SA编程的细胞死亡 12 9 All SZGR 2.0 genes in this pathway
PID P73Pathway 79 59 All SZGR 2.0 genes in this pathway
PID FOXO途径 49 43 All SZGR 2.0 genes in this pathway
PID P75 NTR途径 69 51 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 43 33 All SZGR 2.0 genes in this pathway
Reactome细胞死亡信号通过Nrage NRIF和NADE传导 60 43 All SZGR 2.0 genes in this pathway
REACTOME我正常受体介导的团体关系NALLING 81 61 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 17 12 All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 30 21 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央DN 634 384 All SZGR 2.0 genes in this pathway
Gary CD5目标 473 314 All SZGR 2.0 genes in this pathway
PIEPOLI LGI1 TARGETS UP 15 11 All SZGR 2.0 genes in this pathway
奥斯曼膀胱癌DN 406 230 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175 108 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
多德鼻咽癌DN 1375 806 All SZGR 2.0 genes in this pathway
甲状腺癌的Rodrigues分化不佳的DN 805 505 All SZGR 2.0 genes in this pathway
lau凋亡CDKN2A UP 55 40 All SZGR 2.0 genes in this pathway
chebotaev gr目标 77 62 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
TGFB1通过smad4 up tgfb1的ramjaun凋亡 7 6 All SZGR 2.0 genes in this pathway
标记HDAC目标 23 15 All SZGR 2.0 genes in this pathway
Perez TP53目标 1174 695 All SZGR 2.0 genes in this pathway
Perez TP63目标 355 243 All SZGR 2.0 genes in this pathway
Perez TP53和TP63目标 205 145 All SZGR 2.0 genes in this pathway
Galluzzi通透性线粒体 43 31 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 4 61 34 All SZGR 2.0 genes in this pathway
YAN ESCAPE FROM ANOIKIS 24 19 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向 414 287 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络 1442 892 All SZGR 2.0 genes in this pathway
里克曼肿瘤区分良好，而不是很差 236 139 All SZGR 2.0 genes in this pathway
brocke凋亡由IL6逆转 144 98 All SZGR 2.0 genes in this pathway
Okumura炎症反应LPS 183 115 All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 All SZGR 2.0 genes in this pathway
伊万诺娃造血干细胞 254 164 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
Bild E2F3致癌特征 246 153 All SZGR 2.0 genes in this pathway
monnier tradiatiation肿瘤逃脱DN 373 196 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7 98 63 All SZGR 2.0 genes in this pathway
Stearman肺癌早期与晚期DN 61 39 All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变 180 114 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY DN 58 39 All SZGR 2.0 genes in this pathway
级结肠癌 871 505 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200 115 All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
池子侵入性乳腺癌 288 168 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 75 43 All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP 36 23 All SZGR 2.0 genes in this pathway
PYEON CANCAR CANCAR HEAD和NECK与颈椎 193 95 All SZGR 2.0 genes in this pathway
YAO对孕酮簇1的时间反应1 68 50 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 61 44 All SZGR 2.0 genes in this pathway
Qi缺氧 140 96 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标 824 528 All SZGR 2.0 genes in this pathway
ikeda mir30目标dn 27 24 All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移7 403 240 All SZGR 2.0 genes in this pathway
Delacroix Rarg Bound MEF 367 231 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
Vanoevelen肌发生SIN3A靶标 220 133 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上 1839 928 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-10 4111 4118 1A，M8 hsa-miR-10a UACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10b uacccuguagaaccgaauuugu
mir-101 2255 2262 1A，M8 hsa-miR-101 uacaguacugauaacugaag
mir-124.1 465 471 M8 HSA-MIR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 465 471 1a hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
mir-130/301 4093 4099 M8 hsa-miR-130abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-144 2256 2262 1a HSA-MIR-144 UACAGUAUAGAUGAUGUACUAG
mir-148/152 4094 4101 1A，M8 hsa-miR-148a ucagugcacuacaacuuugu
HSA-MIR-152brain UCAGUGCAUGACACUUGGG
hsa-miR-148b ucagugcaucacacaacuuugu
hsa-miR-148a ucagugcacuacaacuuugu
HSA-MIR-152brain UCAGUGCAUGACACUUGGG
hsa-miR-148b ucagugcaucacacaacuuugu
miR-149 444 450 M8 HSA-MIR-149brain Ucuggcuccucuucuucacuccc
miR-17-5p/20/93.mr/106/519.d 1999 2006 1A，M8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-181 208 215 1A，M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain aacauucauuguugucggggguggguu
miR-19 4092 4098 M8 HSA-MIR-19A ugugcaaauaugauaugaaaacuga
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
mir-214 3734 3741 1A，M8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
mir-221/222 4052 4059 1A，M8 hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain agcuacaucuggcuacugggucuc
miR-24 2678 2685 1A，M8 hsa-miR-24SZ uggcucucagagcaggaagag
hsa-miR-24SZ uggcucucagagcaggaagag
mir-25/32/92/363/367 4134 4141 1A，M8 hsa-miR-25brain Cauugcacuugucucggucuga
hsa-miR-32 uauugcacauacuaaguugc
HSA-MIR-92 uauugcacuugucccgcgcug
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
hsa-miR-25brain Cauugcacuugucucggucuga
hsa-miR-32 uauugcacauacuaaguugc
HSA-MIR-92 uauugcacuugucccgcgcug
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
mir-30-5p 288 295 1A，M8 HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-339 4110 4116 M8 hsa-miR-339 ucccuccuccaggagcuca
miR-376 2184 2191 1A，M8 HSA-MIR-376A aucauagaaaaauccacgu
HSA-MIR-376B AUCAUAGAGGAAAAUCCAUGUU
miR-381 2859 2865 1a HSA-MIR-381 uauacaagggcaagcucucugu
miR-496 211 217 1a HSA-MIR-496 Auuacauggccaaucuc
mir-9 1927 1934 1A，M8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
mir-93.hd/291-3p/294/295/302/372/373/520 1998 2004 M8 HSA-MIR-93brain aaagugcuguucgugcagguag
hsa-miR-302a uaagugcuugcauguuuguga
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
HSA-MIR-372 AAAGUGCUGCGACAUUUGAGCGU
HSA-MIR-373 Gaagugcuucgauuuggggugu
HSA-MIR-520E Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b aaagugcuuuuuuagaggg
hsa-miR-520c aaagugcuuuuuuaggggug
hsa-miR-520d aaaguguuugugggguggguu