Gene Page:chaf1a
Summary？
| 基因 | 10036 |
| 象征 | chaf1a |
| Synonyms | CAF-1 | CAF1 | CAF1B | CAF1P150 | P150 |
| Description | 染色质组装因子1亚基A |
| Reference | MIM：601246|HGNC：HGNC：1910|Ensembl:ENSG00000167670|HPRD：03148|Vega:OTTHUMG00000181922 |
| 基因类型 | 蛋白质编码 |
| Map location | 19p13.3 |
| Pascal p-value | 0.218 |
| 胎儿β | 0.763 |
| DMG | 1 (# studies) |
| 主持人 | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere 小脑 皮质 海马 伏隔核基底神经节 Putamen basal ganglia |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG：Wockner_2014 | 全基因组DNA甲基化分析 | 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 | 2 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：0.0064 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | 染色体 | 位置 | Nearest gene | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| CG04346879 | 19 | 4402785 | chaf1a | 1.325E-4 | -0.214 | 0.03 | DMG：Wockner_2014 |
| ch.19.239668R | 19 | 4434073 | chaf1a | 2.035E-4 | -0.599 | 0.035 | DMG：Wockner_2014 |
eQTL annotation
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS12462529 | 19 | 4359525 | chaf1a | ENSG00000167670.11 | 7.11E-7 | 0.01 | -43134 | gtex_brain_ba24 |
| rs7769 | 19 | 4360543 | chaf1a | ENSG00000167670.11 | 9.539E-7 | 0.01 | -42116 | gtex_brain_ba24 |
| RS11670201 | 19 | 4364777 | chaf1a | ENSG00000167670.11 | 1.026E-6 | 0.01 | -37882 | gtex_brain_ba24 |
| rs11666453 | 19 | 4368797 | chaf1a | ENSG00000167670.11 | 9.384E-7 | 0.01 | -33862 | gtex_brain_ba24 |
| rs56033249 | 19 | 4369447 | chaf1a | ENSG00000167670.11 | 9.347E-7 | 0.01 | -33212 | gtex_brain_ba24 |
| rs11667543 | 19 | 4374850 | chaf1a | ENSG00000167670.11 | 8.805e-7 | 0.01 | -27809 | gtex_brain_ba24 |
| rs11085073 | 19 | 4375162 | chaf1a | ENSG00000167670.11 | 9.446e-7 | 0.01 | -27497 | gtex_brain_ba24 |
| rs62129349 | 19 | 4385659 | chaf1a | ENSG00000167670.11 | 4.372E-7 | 0.01 | -17000 | gtex_brain_ba24 |
| rs11085074 | 19 | 4386352 | chaf1a | ENSG00000167670.11 | 4.368e-7 | 0.01 | -16307 | gtex_brain_ba24 |
| RS55637375 | 19 | 4386845 | chaf1a | ENSG00000167670.11 | 4.366E-7 | 0.01 | -15814 | gtex_brain_ba24 |
| rs62129351 | 19 | 4387125 | chaf1a | ENSG00000167670.11 | 6.666E-7 | 0.01 | -15534 | gtex_brain_ba24 |
| RS9973266 | 19 | 4392715 | chaf1a | ENSG00000167670.11 | 5.636E-7 | 0.01 | -9944 | gtex_brain_ba24 |
| rs62129353 | 19 | 4395763 | chaf1a | ENSG00000167670.11 | 4.619E-7 | 0.01 | -6896 | gtex_brain_ba24 |
| rs62129354 | 19 | 4396505 | chaf1a | ENSG00000167670.11 | 4.441E-7 | 0.01 | -6154 | gtex_brain_ba24 |
| rs62129355 | 19 | 4397034 | chaf1a | ENSG00000167670.11 | 4.687E-7 | 0.01 | -5625 | gtex_brain_ba24 |
| rs62129356 | 19 | 4400314 | chaf1a | ENSG00000167670.11 | 3.34E-7 | 0.01 | -2345 | gtex_brain_ba24 |
| RS2230636 | 19 | 4409756 | chaf1a | ENSG00000167670.11 | 1.114E-7 | 0.01 | 7097 | gtex_brain_ba24 |
| RS56411083 | 19 | 4410646 | chaf1a | ENSG00000167670.11 | 1.062E-7 | 0.01 | 7987 | gtex_brain_ba24 |
| RS34080966 | 19 | 4417845 | chaf1a | ENSG00000167670.11 | 8.978E-8 | 0.01 | 15186 | gtex_brain_ba24 |
| rs56227586 | 19 | 4418515 | chaf1a | ENSG00000167670.11 | 9.793E-8 | 0.01 | 15856 | gtex_brain_ba24 |
| RS56272533 | 19 | 4420042 | chaf1a | ENSG00000167670.11 | 1.004e-7 | 0.01 | 17383 | gtex_brain_ba24 |
| RS56088814 | 19 | 4422178 | chaf1a | ENSG00000167670.11 | 1.585E-7 | 0.01 | 19519 | gtex_brain_ba24 |
| RS11668886 | 19 | 4423419 | chaf1a | ENSG00000167670.11 | 5.083E-7 | 0.01 | 20760 | gtex_brain_ba24 |
| rs59488897 | 19 | 4425236 | chaf1a | ENSG00000167670.11 | 8.978E-8 | 0.01 | 22577 | gtex_brain_ba24 |
| RS55660045 | 19 | 4425305 | chaf1a | ENSG00000167670.11 | 8.978E-8 | 0.01 | 22646 | gtex_brain_ba24 |
| rs62130978 | 19 | 4429007 | chaf1a | ENSG00000167670.11 | 9.793E-8 | 0.01 | 26348 | gtex_brain_ba24 |
| rs62130979 | 19 | 4432444 | chaf1a | ENSG00000167670.11 | 8.858e-8 | 0.01 | 29785 | gtex_brain_ba24 |
| rs12459919 | 19 | 4434503 | chaf1a | ENSG00000167670.11 | 8.978E-8 | 0.01 | 31844 | gtex_brain_ba24 |
| rs11666856 | 19 | 4437450 | chaf1a | ENSG00000167670.11 | 3.259E-7 | 0.01 | 34791 | gtex_brain_ba24 |
| RS11669263 | 19 | 4441407 | chaf1a | ENSG00000167670.11 | 8.978E-8 | 0.01 | 38748 | gtex_brain_ba24 |
| RS56156435 | 19 | 4444654 | chaf1a | ENSG00000167670.11 | 3.568e-7 | 0.01 | 41995 | gtex_brain_ba24 |
| rs760369 | 19 | 4449287 | chaf1a | ENSG00000167670.11 | 9.908E-8 | 0.01 | 46628 | gtex_brain_ba24 |
| rs1127888 | 19 | 4454083 | chaf1a | ENSG00000167670.11 | 1.592E-7 | 0.01 | 51424 | gtex_brain_ba24 |
| RS72990643 | 19 | 4454736 | chaf1a | ENSG00000167670.11 | 1.586E-7 | 0.01 | 52077 | gtex_brain_ba24 |
| RS12459922 | 19 | 4455862 | chaf1a | ENSG00000167670.11 | 1.59E-7 | 0.01 | 53203 | gtex_brain_ba24 |
| rs56153949 | 19 | 4457518 | chaf1a | ENSG00000167670.11 | 4.703E-8 | 0.01 | 54859 | gtex_brain_ba24 |
| RS11670503 | 19 | 4458063 | chaf1a | ENSG00000167670.11 | 2.198E-7 | 0.01 | 55404 | gtex_brain_ba24 |
| RS12462529 | 19 | 4359525 | chaf1a | ENSG00000167670.11 | 1.93E-7 | 0 | -43134 | gtex_brain_putamen_basal |
| rs7769 | 19 | 4360543 | chaf1a | ENSG00000167670.11 | 3.706E-8 | 0 | -42116 | gtex_brain_putamen_basal |
| rs62129346 | 19 | 4363289 | chaf1a | ENSG00000167670.11 | 3.21E-10 | 0 | -39370 | gtex_brain_putamen_basal |
| RS11670201 | 19 | 4364777 | chaf1a | ENSG00000167670.11 | 3.732E-8 | 0 | -37882 | gtex_brain_putamen_basal |
| rs732716 | 19 | 4366219 | chaf1a | ENSG00000167670.11 | 1.295E-9 | 0 | -36440 | gtex_brain_putamen_basal |
| rs11085072 | 19 | 4368142 | chaf1a | ENSG00000167670.11 | 2.201E-7 | 0 | -34517 | gtex_brain_putamen_basal |
| rs11666453 | 19 | 4368797 | chaf1a | ENSG00000167670.11 | 3.634e-8 | 0 | -33862 | gtex_brain_putamen_basal |
| rs56033249 | 19 | 4369447 | chaf1a | ENSG00000167670.11 | 3.571E-8 | 0 | -33212 | gtex_brain_putamen_basal |
| rs11667543 | 19 | 4374850 | chaf1a | ENSG00000167670.11 | 3.063e-8 | 0 | -27809 | gtex_brain_putamen_basal |
| rs11085073 | 19 | 4375162 | chaf1a | ENSG00000167670.11 | 3.026e-8 | 0 | -27497 | gtex_brain_putamen_basal |
| rs62129349 | 19 | 4385659 | chaf1a | ENSG00000167670.11 | 8.867E-11 | 0 | -17000 | gtex_brain_putamen_basal |
| rs11085074 | 19 | 4386352 | chaf1a | ENSG00000167670.11 | 8.697E-11 | 0 | -16307 | gtex_brain_putamen_basal |
| RS55637375 | 19 | 4386845 | chaf1a | ENSG00000167670.11 | 8.576E-11 | 0 | -15814 | gtex_brain_putamen_basal |
| rs62129351 | 19 | 4387125 | chaf1a | ENSG00000167670.11 | 1.226E-8 | 0 | -15534 | gtex_brain_putamen_basal |
| RS9973266 | 19 | 4392715 | chaf1a | ENSG00000167670.11 | 1.16e-8 | 0 | -9944 | gtex_brain_putamen_basal |
| rs5826842 | 19 | 4393294 | chaf1a | ENSG00000167670.11 | 2.983E-10 | 0 | -9365 | gtex_brain_putamen_basal |
| rs62129353 | 19 | 4395763 | chaf1a | ENSG00000167670.11 | 7.121E-9 | 0 | -6896 | gtex_brain_putamen_basal |
| rs62129354 | 19 | 4396505 | chaf1a | ENSG00000167670.11 | 6.494E-9 | 0 | -6154 | gtex_brain_putamen_basal |
| rs62129355 | 19 | 4397034 | chaf1a | ENSG00000167670.11 | 4.58e-11 | 0 | -5625 | gtex_brain_putamen_basal |
| rs62129356 | 19 | 4400314 | chaf1a | ENSG00000167670.11 | 1.838E-9 | 0 | -2345 | gtex_brain_putamen_basal |
| RS200677191 | 19 | 4402659 | chaf1a | ENSG00000167670.11 | 7.349e-10 | 0 | 0 | gtex_brain_putamen_basal |
| RS2230636 | 19 | 4409756 | chaf1a | ENSG00000167670.11 | 1.197E-9 | 0 | 7097 | gtex_brain_putamen_basal |
| RS56411083 | 19 | 4410646 | chaf1a | ENSG00000167670.11 | 6.103E-10 | 0 | 7987 | gtex_brain_putamen_basal |
| RS34080966 | 19 | 4417845 | chaf1a | ENSG00000167670.11 | 1.034E-9 | 0 | 15186 | gtex_brain_putamen_basal |
| rs56227586 | 19 | 4418515 | chaf1a | ENSG00000167670.11 | 5.537E-10 | 0 | 15856 | gtex_brain_putamen_basal |
| RS56272533 | 19 | 4420042 | chaf1a | ENSG00000167670.11 | 1.135E-9 | 0 | 17383 | gtex_brain_putamen_basal |
| RS56088814 | 19 | 4422178 | chaf1a | ENSG00000167670.11 | 6.092E-10 | 0 | 19519 | gtex_brain_putamen_basal |
| RS11668886 | 19 | 4423419 | chaf1a | ENSG00000167670.11 | 9.97E-10 | 0 | 20760 | gtex_brain_putamen_basal |
| rs59488897 | 19 | 4425236 | chaf1a | ENSG00000167670.11 | 1.034E-9 | 0 | 22577 | gtex_brain_putamen_basal |
| RS55660045 | 19 | 4425305 | chaf1a | ENSG00000167670.11 | 1.034E-9 | 0 | 22646 | gtex_brain_putamen_basal |
| rs62130978 | 19 | 4429007 | chaf1a | ENSG00000167670.11 | 1.03E-9 | 0 | 26348 | gtex_brain_putamen_basal |
| rs62130979 | 19 | 4432444 | chaf1a | ENSG00000167670.11 | 5.601E-10 | 0 | 29785 | gtex_brain_putamen_basal |
| rs12459919 | 19 | 4434503 | chaf1a | ENSG00000167670.11 | 1.034E-9 | 0 | 31844 | gtex_brain_putamen_basal |
| rs11666856 | 19 | 4437450 | chaf1a | ENSG00000167670.11 | 1.422e-11 | 0 | 34791 | gtex_brain_putamen_basal |
| RS11669263 | 19 | 4441407 | chaf1a | ENSG00000167670.11 | 1.034E-9 | 0 | 38748 | gtex_brain_putamen_basal |
| RS56156435 | 19 | 4444654 | chaf1a | ENSG00000167670.11 | 2.381E-11 | 0 | 41995 | gtex_brain_putamen_basal |
| rs78869060 | 19 | 4444742 | chaf1a | ENSG00000167670.11 | 5.083E-11 | 0 | 42083 | gtex_brain_putamen_basal |
| rs760369 | 19 | 4449287 | chaf1a | ENSG00000167670.11 | 7.253E-12 | 0 | 46628 | gtex_brain_putamen_basal |
| rs1127888 | 19 | 4454083 | chaf1a | ENSG00000167670.11 | 1.417e-11 | 0 | 51424 | gtex_brain_putamen_basal |
| RS72990643 | 19 | 4454736 | chaf1a | ENSG00000167670.11 | 1.418E-11 | 0 | 52077 | gtex_brain_putamen_basal |
| RS12459922 | 19 | 4455862 | chaf1a | ENSG00000167670.11 | 1.414e-11 | 0 | 53203 | gtex_brain_putamen_basal |
| rs56153949 | 19 | 4457518 | chaf1a | ENSG00000167670.11 | 1.134E-9 | 0 | 54859 | gtex_brain_putamen_basal |
| RS11670503 | 19 | 4458063 | chaf1a | ENSG00000167670.11 | 1.475E-11 | 0 | 55404 | gtex_brain_putamen_basal |
| rs143191932 | 19 | 4459785 | chaf1a | ENSG00000167670.11 | 6.021E-7 | 0 | 57126 | gtex_brain_putamen_basal |
| RS149060351 | 19 | 4460005 | chaf1a | ENSG00000167670.11 | 7.108E-7 | 0 | 57346 | gtex_brain_putamen_basal |
| RS11669260 | 19 | 4460272 | chaf1a | ENSG00000167670.11 | 8.009e-7 | 0 | 57613 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0003682 | 染色质结合 | TAS | 7600578 | |
| GO:0051082 | unfolded protein binding | TAS | 7600578 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0006355 | 调节转录，DNA依赖性的调节 | IEA | - | |
| 去：0006350 | 转录 | IEA | - | |
| 去：0006461 | protein complex assembly | TAS | 7600578 | |
| 去：0006335 | DNA复制依赖性核小体组装 | TAS | 7600578 | |
| 去：0006281 | DNA repair | IEA | - | |
| 去：0006260 | 基因复制 | IEA | - | |
| GO:0007049 | cell cycle | IEA | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005634 | nucleus | IEA | - | |
| 去：0005678 | 染色质组装复合物 | TAS | 7600578 |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ASF1A | CGI-98 | CIA | DKFZp547E2110 | HSPC146 | ASF1抗沉降函数1同源物A（S. cerevisiae） | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 11897662 |
| ASF1B | CIA-II | FLJ10604 | ASF1抗沉降函数1同源物B（S. cerevisiae） | Affinity Capture-MS 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 11897662|17353931 |
| baz1b | WBSCR10 | WBSCR9 | WSTF | bromodomain adjacent to zinc finger domain, 1B | - | HPRD | 12837248 |
| BLM | BS |MGC126616 |MGC131618 |MGC131620 |recq2 |recql2 |RECQL3 | 布卢姆综合症 | 亲和力捕获 - 韦斯特恩 Far Western Two-hybrid |
Biogrid | 15143166 |
| CBX1 | CBX | HP1-BETA | HP1Hs-beta | HP1Hsbeta | M31 | MOD1 | p25beta | Chromobox同源物1（HP1β同源果蝇） | - | HPRD | 10549285 |
| CBX5 | HP1 |HP1A | chromobox homolog 5 (HP1 alpha homolog, Drosophila) | - | HPRD | 10549285|10938122 |
| CBX5 | HP1 |HP1A | chromobox homolog 5 (HP1 alpha homolog, Drosophila) | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 10938122|12697822 |
| CHAF1B | CAF-1 | CAF-IP60 | CAF1 | CAF1A | CAF1P60 | MPHOSPH7 | MPP7 | 染色质组装因子1，亚基B（P60） | - | HPRD,BioGRID | 9614144 |
| Hist1H3E | H3.1 |H3/D |H3FD | histone cluster 1, H3e | CAF-1 p150 interacts with H3.1. This interaction was modeled on a demonstrated interaction between human CAF-1 p150 and H3.1 from an unspecified species. | 绑定 | 15664198 |
| MBD1 | CXXC3 |PCM1 |rft | methyl-CpG binding domain protein 1 | - | HPRD,BioGRID | 12697822 |
| MBD1 | CXXC3 |PCM1 |rft | methyl-CpG binding domain protein 1 | MBD1interacts with CAF-1. | 绑定 | 15327775 |
| PCNA | MGC8367 | 增殖细胞核抗原 | - | HPRD,BioGRID | 10648606 |
| SETDB1 | ESET | KG1T | KIAA0067 | KMT1E | 设定域，分叉1 | SETDB1与CAF-1相互作用。 | 绑定 | 15327775 |
| tcerg1 | CA150 |MGC133200 |taf2s | 转录伸长调节器1 | - | HPRD,BioGRID | 15456888 |