Gene Page:TOM1L1
Summary?
| GeneID | 10040 |
| Symbol | TOM1L1 |
| Synonyms | OK/KNS-CL.3|SRCASM |
| Description | target of myb1 like 1 membrane trafficking protein |
| Reference | MIM:604701|HGNC:HGNC:11983|Ensembl:ENSG00000141198|HPRD:05266|Vega:OTTHUMG00000177816 |
| Gene type | protein-coding |
| Map location | 17q23.2 |
| Pascal p-value | 0.031 |
| eGene | Caudate basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17027208 | chr3 | 31219519 | TOM1L1 | 10040 | 0.18 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DNER | 0.63 | 0.58 |
| AL359079.1 | 0.63 | 0.55 |
| EPHA8 | 0.61 | 0.45 |
| ADAMTS15 | 0.61 | 0.54 |
| SHC1 | 0.60 | 0.66 |
| CDR2 | 0.59 | 0.52 |
| EHD4 | 0.59 | 0.55 |
| RGS19 | 0.59 | 0.41 |
| RNF220 | 0.59 | 0.49 |
| PDE5A | 0.58 | 0.56 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.37 | -0.28 |
| SYCP3 | -0.37 | -0.34 |
| AL050337.1 | -0.34 | -0.26 |
| AL138743.2 | -0.33 | -0.19 |
| AC120053.1 | -0.31 | -0.32 |
| FAM159B | -0.31 | -0.40 |
| GNG11 | -0.30 | -0.20 |
| AC104794.1 | -0.30 | -0.17 |
| C1orf54 | -0.29 | -0.19 |
| AF347015.31 | -0.29 | -0.23 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CCDC47 | GK001 | MSTP041 | coiled-coil domain containing 47 | Two-hybrid | BioGRID | 16169070 |
| COPS7A | MGC110877 | COP9本构photomorphogenic同族体亚基7A (Arabidopsis) | Two-hybrid | BioGRID | 16169070 |
| CUGBP1 | BRUNOL2 | CUG-BP | CUGBP | NAB50 | hNab50 | CUG triplet repeat, RNA binding protein 1 | Two-hybrid | BioGRID | 16169070 |
| CWF19L1 | FLJ10998 | CWF19-like 1, cell cycle control (S. pombe) | Two-hybrid | BioGRID | 16169070 |
| FYN | MGC45350 | SLK | SYN | FYN oncogene related to SRC, FGR, YES | Reconstituted Complex | BioGRID | 11711534 |
| GLUD2 | GDH2 | GLUDP1 | glutamate dehydrogenase 2 | Two-hybrid | BioGRID | 16169070 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 11711534 |
| GSN | DKFZp313L0718 | gelsolin (amyloidosis, Finnish type) | Two-hybrid | BioGRID | 16169070 |
| NDC80 | HEC | HEC1 | KNTC2 | TID3 | hsNDC80 | NDC80 homolog, kinetochore complex component (S. cerevisiae) | Two-hybrid | BioGRID | 16169070 |
| NOMO1 | Nomo | PM5 | NODAL modulator 1 | Two-hybrid | BioGRID | 16169070 |
| PDPN | AGGRUS | GP36 | GP40 | Gp38 | HT1A-1 | OTS8 | PA2.26 | T1A | T1A-2 | podoplanin | Two-hybrid | BioGRID | 16169070 |
| PELP1 | HMX3 | MNAR | P160 | proline, glutamate and leucine rich protein 1 | Two-hybrid | BioGRID | 16169070 |
| PHYH | LN1 | LNAP1 | PAHX | PHYH1 | RD | phytanoyl-CoA 2-hydroxylase | Two-hybrid | BioGRID | 16169070 |
| PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | - | HPRD | 11711534 |
| PWP2 | EHOC-17 | PWP2H | PWP2 periodic tryptophan protein homolog (yeast) | Two-hybrid | BioGRID | 16169070 |
| UBXN4 | FLJ23318 | KIAA0242 | KIAA2042 | UBXD2 | UBXDC1 | erasin | UBX domain protein 4 | Two-hybrid | BioGRID | 16169070 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| ZHONG RESPONSE TO AZACITIDINE AND TSA DN | 70 | 38 | All SZGR 2.0 genes in this pathway |
| DAVICIONI MOLECULAR ARMS VS ERMS UP | 332 | 228 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP | 94 | 59 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP | 185 | 126 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | 329 | 196 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA FOREVER DN | 31 | 23 | All SZGR 2.0 genes in this pathway |
| LANDIS ERBB2 BREAST TUMORS 324 UP | 150 | 93 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA UP | 536 | 340 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER BASAL VS LULMINAL | 330 | 215 | All SZGR 2.0 genes in this pathway |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | 114 | 58 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING VIA SMAD4 UP | 108 | 66 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| ALCALAY AML BY NPM1 LOCALIZATION UP | 140 | 83 | All SZGR 2.0 genes in this pathway |
| GUO HEX TARGETS DN | 65 | 36 | All SZGR 2.0 genes in this pathway |
| GERY CEBP TARGETS | 126 | 90 | All SZGR 2.0 genes in this pathway |
| LI WILMS TUMOR VS FETAL KIDNEY 1 UP | 182 | 119 | All SZGR 2.0 genes in this pathway |
| YAGI AML FAB MARKERS | 191 | 131 | All SZGR 2.0 genes in this pathway |
| RAMALHO STEMNESS UP | 206 | 118 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE UP | 97 | 61 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| BLUM RESPONSE TO SALIRASIB UP | 245 | 159 | All SZGR 2.0 genes in this pathway |
| SCHRAETS MLL TARGETS UP | 35 | 21 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |
| NOUSHMEHR GBM SILENCED BY METHYLATION | 50 | 32 | All SZGR 2.0 genes in this pathway |
| PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN | 157 | 106 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |
| VANLOO SP3 TARGETS DN | 89 | 47 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |