Gene Page:RANBP9
Summary？
| 基因 | 10048 |
| 象征 | RANBP9 |
| Synonyms | BPM-L | BPM90 | RANBPM | RANBP7 |
| Description | 运行结合蛋白9 |
| Reference | MIM：603854|HGNC：HGNC：13727|Ensembl：ENSG00000010017|HPRD:04835|Vega:OTTHUMG00000015642 |
| 基因类型 | 蛋白质编码 |
| Map location | 6p23 |
| Pascal p-value | 0.012 |
| Sherlock p-value | 4.646E-5 |
| 胎儿β | -0.348 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| GSMA_I | Genome scan meta-analysis | PSR：0.0159 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0833 |
Section I. Genetics and epigenetics annotation
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
| MAP3K1 | 0.78 | 0.62 |
| AP001979.1 | 0.77 | 0.66 |
| TSPAN9 | 0.77 | 0.64 |
| Spata13 | 0.77 | 0.67 |
| ZNF503 | 0.76 | 0.64 |
| trerf1 | 0.76 | 0.77 |
| FOXP4 | 0.75 | 0.66 |
| 拉拉 | 0.75 | 0.67 |
| MEIS1 | 0.75 | 0.63 |
| AC010997.1 | 0.75 | 0.59 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
| AF347015.21 | -0.45 | -0.47 |
| C1orf54 | -0.42 | -0.48 |
| Sycp3 | -0.41 | -0.49 |
| AF347015.31 | -0.40 | -0.41 |
| MT-CO2 | -0.40 | -0.40 |
| VAMP5 | -0.39 | -0.40 |
| GNG11 | -0.38 | -0.42 |
| HIGD1B | -0.37 | -0.36 |
| clec2b | -0.37 | -0.42 |
| IL32 | -0.37 | -0.45 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005515 | 蛋白质结合 | IPI | 12220523|12421467|14500717 |
|
| 去：0008536 | RAN GTPase结合 | TAS | 9817760 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0006461 | protein complex assembly | TAS | 9817760 | |
| 去：0007020 | 微管成核 | nas | 12220523 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005875 | microtubule associated complex | TAS | 9817760 | |
| 去：0005634 | nucleus | 艾达 | 12220523 | |
| 去：0005737 | cytoplasm | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ar | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | 雄激素受体 | - | HPRD,BioGRID | 12361945 |
| AXL | JTK11 | UFO | AXL受体酪氨酸激酶 | AXL与RANBPM相互作用。 | 绑定 | 12470648 |
| Bace1 | asp2 |贝丝|FLJ90568 |HSPC104 |KIAA1149 | β位点应用酶1 | BACE1与RANBP9（RANBPM）相互作用。这种相互作用是在小鼠BACE1和人RANBPM之间的相互作用上建模的。 | 绑定 | 15606899 |
| 卡布1 | 卡布 | Calbindin 1，28KDA | - | HPRD,BioGRID | 12684061 |
| DISC1 | C1orf136 |FLJ13381 |FLJ21640 |FLJ25311 |FLJ41105 |KIAA0457 |SCZD9 | 精神分裂症中断1 | - | HPRD,BioGRID | 12812986 |
| DISC1 | C1orf136 |FLJ13381 |FLJ21640 |FLJ25311 |FLJ41105 |KIAA0457 |SCZD9 | 精神分裂症中断1 | Disc-1与RANBPM相互作用。 | 绑定 | 12812986 |
| dyrk1b | 黑暗 | 双特异性酪氨酸（Y） - 磷酸化调节激酶1B | - | HPRD,BioGRID | 14500717 |
| FMR1 | FMRP | FRAXA | MGC87458 | POF | POF1 | 脆弱的X智力低下1 | FMR1（FMRP）与RANBP9（RANBPM）相互作用。 | 绑定 | 15381419 |
| hipk2 | DKFZP686K02111 |FLJ23711 |Pro0593 | 同源域相互作用蛋白激酶2 | 核蛋白激酶HIPK2与RAN结合蛋白RANBPM相互作用 | 绑定 | 12220523 |
| hipk2 | DKFZP686K02111 |FLJ23711 |Pro0593 | 同源域相互作用蛋白激酶2 | - | HPRD,BioGRID | 12220523 |
| ITGB2 | CD18 |小伙子|lcamb |LFA-1 |Mac-1 |MF17 |MFI7 | 整合素，β2（补体组件3受体3和4亚基） | RANBPM与β-2整合素LFA-1相互作用。 | 绑定 | 14722085 |
| L1CAM | CAML1 | CD171 | HSAS | HSAS1 | MASA | MIC5 | N-CAML1 | S10 | SPG1 | L1细胞粘附分子 | L1CAM与RANBPM相互作用。 | 绑定 | 16000162 |
| 见面 | auts9 |HGFR |RCCP2 |C-MET | met proto-oncogene (hepatocyte growth factor receptor) | - | HPRD,BioGRID | 12147692 |
| MPHOSPH8 | FLJ35237 |HSMPP8 |twa3 |mpp8 | M期磷蛋白8 | - | HPRD,BioGRID | 12559565 |
| NR3C1 | GCCR |GCR |gr |grl | 核受体亚科3，C组，成员1（糖皮质激素受体） | 亲和力捕获 - 韦斯特恩 Two-hybrid |
Biogrid | 12361945 |
| RAN | arA24 | Gsp1 | TC4 | RAN，RAS成员Ras Oncogene家族 | - | HPRD,BioGRID | 9817760 |
| RNPS1 | E5.1 |MGC117332 | RNA binding protein S1, serine-rich domain | Affinity Capture-MS | Biogrid | 17353931 |
| S100A7 | psor1 |S100A7C | S100钙结合蛋白A7 | - | HPRD,BioGRID | 12421467 |
| UCHL1 | park5 |pgp9.5 |UCH-L1 | 泛素羧酸末端酯酶L1（泛素硫酯酶） | - | HPRD,BioGRID | 12082530 |
| USP11 | UHX1 | 泛素特异性肽酶11 | - | HPRD,BioGRID | 12084015 |
Section V. Pathway annotation
第六节。microRNA注释
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| mir-101 | 507 | 514 | 1A，M8 | hsa-miR-101 | uacaguacugauaacugaag |
| miR-144 | 508 | 514 | 1a | HSA-MIR-144 | UACAGUAUAGAUGAUGUACUAG |
| miR-200bc/429 | 681 | 688 | 1A，M8 | hsa-miR-200b | UAAUACUGCCUGGUAAUGAUGAC |
| hsa-miR-200c | UAAUACUGCCGGGUAAUGAUGG | ||||
| hsa-miR-429 | UAAUACUGUCUGGUAAAACCGU | ||||
| mir-208 | 753 | 759 | 1a | hsa-miR-208 | auaagacgaaaaaagcuugu |
| mir-214 | 64 | 70 | 1a | hsa-miR-214brain | ACAGCAGGCACAGACAGGCAG |
| mir-25/32/92/363/367 | 810 | 816 | 1a | hsa-miR-25brain | Cauugcacuugucucggucuga |
| hsa-miR-32 | uauugcacauacuaaguugc | ||||
| HSA-MIR-92 | uauugcacuugucccgcgcug | ||||
| HSA-MIR-367 | Aauugcacuuuagcaaugga | ||||
| HSA-MIR-92BSZ | uauugcacucgucccgcgcuc | ||||
| miR-26 | 517 | 523 | 1a | HSA-MIR-26Abrain | UUCAAGUAAUCCAGGAUAGGC |
| HSA-MIR-26BSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
| mir-30-5p | 137 | 143 | 1a | HSA-MIR-30A-5P | uguaaaacauccuccugagaag |
| hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
| hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
| hsa-miR-30bSZ | uguaaacauccuaccucucagcu | ||||
| hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||
| mir-323 | 501 | 507 | M8 | hsa-miR-323brain | gcacauuacggucgaccucu |
| mir-410 | 718 | 724 | 1a | hsa-miR-410 | aauauaacacagauggcugu |
| mir-411 | 748 | 754 | M8 | hsa-miR-411 | aacacgguccacuaacccucagu |
| miR-496 | 375 | 381 | 1a | HSA-MIR-496 | Auuacauggccaaucuc |
| miR-499 | 753 | 759 | 1a | HSA-MIR-499 | UUAAGACUUGCAGUGAUGUUUAA |
| mir-505 | 478 | 484 | M8 | hsa-miR-505 | gucaacuugcugguuccuc |