Gene Page:ABCB6

Summary?
GeneID 10058
Symbol ABCB6
Synonyms ABC|ABC14|DUH3|LAN|MCOPCB7|MTABC3|PRP|PSHK2|umat
Description ATP binding cassette subfamily B member 6 (Langereis blood group)
Reference MIM:605452|HGNC:HGNC:47|Ensembl:ENSG00000115657|HPRD:09261|Vega:OTTHUMG00000133131
Gene type protein-coding
Map location 2q36
Pascal p-value 1.158E-5
Sherlock p-value 0.492
eGene Cerebellar Hemisphere
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00916
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17036007 chr12 105032580 ABCB6 10058 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13- 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PSMD8 0.88 0.87
NHP2L1 0.85 0.81
APEH 0.83 0.80
UQCRC1 0.82 0.81
C19orf62 0.82 0.79
WDR45 0.82 0.79
COPS6 0.82 0.77
ARFIP2 0.81 0.78
C14orf119 0.81 0.79
LSM4 0.81 0.79
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.18 -0.64 -0.56
AF347015.26 -0.60 -0.50
AF347015.8 -0.58 -0.45
MT-ATP8 -0.58 -0.49
AC010300.1 -0.57 -0.59
AF347015.2 -0.56 -0.44
AF347015.21 -0.56 -0.45
AF347015.33 -0.55 -0.47
AF347015.15 -0.54 -0.44
AF347015.27 -0.54 -0.48

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005524 ATP binding IDA 10837493
去:0016887 ATPase activity IEA -
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006810 transport IDA 10837493
GO:0006879 cellular iron ion homeostasis NAS 11977179
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005739 mitochondrion IDA 10837493
GO:0005740 mitochondrial envelope IDA 10837493
GO:0005741 mitochondrial outer membrane IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0043190 ATP-binding cassette (ABC) transporter complex NAS 11955620

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ABC TRANSPORTERS 44 29 All SZGR 2.0 genes in this pathway
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 34 21 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
SASAI RESISTANCE TO NEOPLASTIC TRANSFROMATION 50 31 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
MENSE缺氧了 98 71 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 141 99 All SZGR 2.0 genes in this pathway
SU TESTIS 76 53 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN DN 19 11 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART VENTRICLE DN 41 28 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON UP 77 47 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217 122 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
QI HYPOXIA 140 96 All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211 119 All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2 111 59 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-29 94 101 1A,m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU