Gene Page:SCAMP2

Summary?
GeneID 10066
Symbol SCAMP2
Synonyms -
Description secretory carrier membrane protein 2
Reference MIM:606912|HGNC:HGNC:10564|Ensembl:ENSG00000140497|HPRD:06073|Vega:OTTHUMG00000142817
Gene type protein-coding
Map location 15q23-q25
Pascal p-value 0.036
Sherlock p-value 0.349
Fetal beta -0.656
DMG 1 (# studies)
eGene Cerebellum
Frontal Cortex BA9
Myers' cis & trans
Support EXOCYTOSIS

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg15299233 15 75162173 SCAMP2 4.519E-4 0.425 0.045 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4501739 chrX 35960848 SCAMP2 10066 0.04 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RALY 0.95 0.92
PPP4C 0.95 0.93
MAD2L2 0.95 0.90
RNASEH2A 0.95 0.89
SNRPA 0.95 0.89
CENPV 0.94 0.89
SMARCB1 0.94 0.90
IMPDH2 0.93 0.92
BAT1 0.93 0.89
WRAP53 0.93 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.70 -0.86
HLA-F -0.69 -0.74
AF347015.33 -0.68 -0.86
AF347015.31 -0.68 -0.84
MT-CO2 -0.67 -0.83
MT-CYB -0.67 -0.85
AIFM3 -0.66 -0.71
ALDOC -0.66 -0.69
C5orf53 -0.66 -0.69
AF347015.8 -0.66 -0.86

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID ARF6 TRAFFICKING PATHWAY 49 34 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230 115 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE 105 68 All SZGR 2.0 genes in this pathway
LIU COMMON CANCER GENES 79 47 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261 155 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway