Gene Page:PDCD7

Summary?
GeneID 10081
Symbol PDCD7
Synonyms ES18|HES18
Description programmed cell death 7
Reference MIM:608138|HGNC:HGNC:8767|Ensembl:ENSG00000090470|HPRD:09736|Vega:OTTHUMG00000133117
Gene type protein-coding
Map location 15q22.31
Pascal p-value 0.469
Sherlock p-value 0.662
Fetal beta -0.117
DMG 2 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0263

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23044169 15 65426800 PDCD7 1.61E-6 0.303 0.008 DMG:Wockner_2014
cg05179880 15 65426293 PDCD7 -0.027 0.27 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9846383 chr3 191885041 PDCD7 10081 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ACD 0.89 0.90
TOR2A 0.88 0.91
C16orf59 0.88 0.90
ABCC10 0.88 0.91
C1orf159 0.87 0.90
C17orf70 0.87 0.90
CLN3 0.87 0.88
RCE1 0.87 0.91
C7orf27 0.87 0.91
GTPBP3 0.86 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.64 -0.75
AF347015.31 -0.62 -0.72
AF347015.33 -0.62 -0.72
MT-CO2 -0.61 -0.72
AF347015.8 -0.60 -0.73
MT-CYB -0.60 -0.71
C5orf53 -0.59 -0.64
S100B -0.58 -0.67
AF347015.15 -0.57 -0.69
COPZ2 -0.57 -0.64

Section III. Gene Ontology annotation

Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008380 RNA splicing IC 15146077
GO:0006917 induction of apoptosis IEA -
GO:0006917 induction of apoptosis ISS 10037816
GO:0006915 apoptosis IEA -
GO:0051384 response to glucocorticoid stimulus IEA -
GO:0051384 response to glucocorticoid stimulus ISS 10037816
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005689 U12-dependent spliceosome IDA 15146077

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE DN 33 22 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-410 1295 1301 m8 hsa-miR-410 AAUAUAACACAGAUGGCCUGU