Gene Page:ARPC5

概括?
基因 10092
象征 ARPC5
Synonyms ARC16|dJ127C7.3|p16-Arc
Description 肌动蛋白相关蛋白2/3复合体亚基5
Reference MIM:604227|HGNC:HGNC:708|HPRD:11969|
Gene type protein-coding
Map location 1q25.3
Sherlock p-value 0.647
Fetal beta 0.925
DMG 2 (# studies)
Support STRUCTURAL PLASTICITY

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 4
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 4
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 4
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26018965 1 183604789 arpc5; rgl1 2.628E-4 -0.272 0.038 DMG:Wockner_2014
cg27155653 1 183604774 ARPC5 -0.033 0.27 DMG:Nishioka_2013
cg12737363 1 183604674 ARPC5 2.24E-10 -0.029 5.98E-7 DMG:Jaffe_2016
cg27155653 1 183604774 ARPC5 3.34E-8 -0.012 9.98e-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SUFU 0.97 0.95
C14orf118 0.96 0.95
RNF38 0.96 0.96
RFX7 0.96 0.96
ZNF398 0.95 0.96
ZNF317 0.95 0.97
DCAF5 0.95 0.97
DCP1A 0.95 0.95
RRP1B 0.95 0.95
PRRC1 0.95 0.95
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.71 -0.77
AF347015.31 -0.71 -0.88
MT-CO2 -0.70 -0.89
AIFM3 -0.70 -0.77
FXYD1 -0.70 -0.88
S100B -0.69 -0.83
AF347015.33 -0.69 -0.85
AF347015.27 -0.69 -0.86
HLA-F -0.69 -0.75
IFI27 -0.68 -0.84

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003779 actin binding IEA -
GO:0005515 protein binding 新闻学会 17353931
GO:0005200 structural constituent of cytoskeleton TAS 9230079
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0006928 cell motion TAS 9230079
GO:0030036 actin cytoskeleton organization TAS 9359840
GO:0030833 regulation of actin filament polymerization IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO：0042995 cell projection IEA axon (GO term level: 4) -
GO:0005856 cytoskeleton IEA -
GO:0005737 细胞质 TAS 9359840
GO:0005885 Arp2/3 protein complex TAS 9230079

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 该途径中的所有SZGR 2.0基因
肌动蛋白细胞骨架的KEGG调节 216 144 该途径中的所有SZGR 2.0基因
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 59 36 该途径中的所有SZGR 2.0基因
BIOCARTA SALMONELLA PATHWAY 13 10 该途径中的所有SZGR 2.0基因
BIOCARTA MPR PATHWAY 34 28 该途径中的所有SZGR 2.0基因
Biocarta Rho途径 32 23 该途径中的所有SZGR 2.0基因
BIOCARTA CDC42RAC PATHWAY 16 13 该途径中的所有SZGR 2.0基因
BIOCARTA ACTINY PATHWAY 20 14 该途径中的所有SZGR 2.0基因
PID CDC42 PATHWAY 70 51 该途径中的所有SZGR 2.0基因
PID ERBB1 DOWNSTREAM PATHWAY 105 78 该途径中的所有SZGR 2.0基因
PID PDGFRB PATHWAY 129 103 该途径中的所有SZGR 2.0基因
PID RAC1 PATHWAY 54 37 该途径中的所有SZGR 2.0基因
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 该途径中的所有SZGR 2.0基因
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
RICKMAN METASTASIS DN 261 155 该途径中的所有SZGR 2.0基因
BENPORATH OCT4 TARGETS 290 172 该途径中的所有SZGR 2.0基因
DORSAM HOXA9 TARGETS UP 35 25 该途径中的所有SZGR 2.0基因
LU IL4 SIGNALING 94 56 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
PENG GLUCOSE DEPRIVATION DN 169 112 该途径中的所有SZGR 2.0基因
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 该途径中的所有SZGR 2.0基因
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
JIANG HYPOXIA CANCER 83 52 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性1 528 324 该途径中的所有SZGR 2.0基因
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER CANCER UP 973 570 该途径中的所有SZGR 2.0基因
WANG TUMOR INVASIVENESS UP 374 247 该途径中的所有SZGR 2.0基因
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 102 65 该途径中的所有SZGR 2.0基因
CHEN METABOLIC SYNDROM NETWORK 1210 725 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181 101 该途径中的所有SZGR 2.0基因
IKEDA MIR133 TARGETS UP 43 27 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 该途径中的所有SZGR 2.0基因
ALFANO MYC TARGETS 239 156 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 865 871 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 865 871 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-141/200a 933 939 m8 hsa-miR-141 uaacacugucugugugugugaugg
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
miR-145 459 465 m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-190 148 155 1A,m8 hsa-miR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-193 379 385 m8 hsa-miR-193a Aacuggccuacaaagucccag
hsa-miR-193b AACUGGCCCUCAAAGUCCCGCUUU
miR-320 104 110 m8 hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA