Gene Page:ARPC3
概括?
| 基因 | 10094 |
| Symbol | ARPC3 |
| Synonyms | ARC21|p21-Arc |
| Description | 肌动蛋白相关蛋白2/3复合体亚基3 |
| Reference | MIM:604225|HGNC:HGNC:706|Ensembl:ENSG00000111229|HPRD:09175|Vega:OTTHUMG00000134333 |
| Gene type | protein-coding |
| Map location | 12q24.11 |
| Pascal p-value | 7.747E-5 |
| Sherlock p-value | 0.721 |
| eGene | Myers' cis & trans |
| Support | STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2CDB.HUMANNRC CompositeSet |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | 与神经相关的关键字的命中：1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17627481 | chr12 | 111777481 | ARPC3 | 10094 | 0.17 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NAE1 | 0.84 | 0.85 |
| CSTF3 | 0.81 | 0.80 |
| PAK1IP1 | 0.81 | 0.83 |
| CDC16 | 0.80 | 0.80 |
| ZNF596 | 0.80 | 0.83 |
| GLT8D1 | 0.80 | 0.82 |
| C17orf42 | 0.80 | 0.82 |
| C7orf36 | 0.80 | 0.85 |
| ZBED5 | 0.79 | 0.84 |
| CCDC90B | 0.79 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.15 | -0.70 | -0.70 |
| AF347015.2 | -0.69 | -0.68 |
| MT-CYB | -0.69 | -0.68 |
| AF347015.27 | -0.68 | -0.66 |
| AF347015.8 | -0.67 | -0.67 |
| AF347015.33 | -0.67 | -0.66 |
| MT-CO2 | -0.67 | -0.64 |
| AF347015.26 | -0.65 | -0.67 |
| AF347015.31 | -0.65 | -0.66 |
| TINAGL1 | -0.62 | -0.67 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003779 | actin binding | IEA | - | |
| GO:0005515 | protein binding | 新闻学会 | 17353931 | |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 9230079 | |
| 生物过程 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006928 | cell motion | TAS | 9230079 | |
| GO:0030833 | regulation of actin filament polymerization | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0042995 | cell projection | IEA | axon (GO term level: 4) | - |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0005885 | Arp2/3 protein complex | TAS | 9230079 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ACTR2 | ARP2 | ARP2 actin-related protein 2 homolog (yeast) | - | HPRD | 9000076 |
| ACTR3 | ARP3 | ARP3 actin-related protein 3 homolog (yeast) | - | HPRD | 9000076 |
| ACTR3 | ARP3 | ARP3 actin-related protein 3 homolog (yeast) | Arp2/3 complex subunits p21 and Arp3 interact | BIND | 11741539 |
| ACTR3 | ARP3 | ARP3 actin-related protein 3 homolog (yeast) | Co-purification | BioGRID | 11741539 |
| ACTR3B | ARP11 | ARP3BETA | DKFZp686O24114 | ARP3 actin-related protein 3 homolog B (yeast) | Affinity Capture-MS | BioGRID | 17353931 |
| ARAP1 | CENTD2 | KIAA0782 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 两个杂交 | BioGRID | 16169070 |
| ARPC1B | ARC41 | p40-ARC | p41-ARC | actin related protein 2/3 complex, subunit 1B, 41kDa | - | HPRD | 9000076 |
| ARPC1B | ARC41 | p40-ARC | p41-ARC | actin related protein 2/3 complex, subunit 1B, 41kDa | - | HPRD | 9230079|11721045 |
| ARPC2 | ARC34 |PNAS-139 |Pro2446 |p34-arc | actin related protein 2/3 complex, subunit 2, 34kDa | - | HPRD,BioGRID | 9230079 |
| ARPC2 | ARC34 |PNAS-139 |Pro2446 |p34-arc | actin related protein 2/3 complex, subunit 2, 34kDa | - | HPRD | 9000076 |
| ARPC4 | ARC20 | MGC13544 | p20-Arc | actin related protein 2/3 complex, subunit 4, 20kDa | - | HPRD,BioGRID | 11162547 |
| ARPC4 | ARC20 | MGC13544 | p20-Arc | actin related protein 2/3 complex, subunit 4, 20kDa | - | HPRD | 9000076 |
| BAT3 | BAG-6 | BAG6 | D6S52E | G3 | HLA-B associated transcript 3 | 两个杂交 | BioGRID | 16169070 |
| CDKN2B | CDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 两个杂交 | BioGRID | 16169070 |
| CTTN | EMS1 | FLJ34459 | cortactin | Affinity Capture-MS | BioGRID | 11018051 |
| EFTUD2 | DKFZp686E24196 | FLJ44695 | KIAA0031 | Snrp116 | Snu114 | U5-116KD | elongation factor Tu GTP binding domain containing 2 | 两个杂交 | BioGRID | 16169070 |
| LGALS4 | GAL4 | L36LBP | lectin, galactoside-binding, soluble, 4 | 两个杂交 | BioGRID | 16169070 |
| PRMT1 | ANM1 | HCP1 | HRMT1L2 | IR1B4 | protein arginine methyltransferase 1 | 两个杂交 | BioGRID | 16169070 |
| RPS4X | CCG2 | DXS306 | FLJ40595 | SCAR | SCR10 | ribosomal protein S4, X-linked | 两个杂交 | BioGRID | 9889097 |
| WAS | IMD2 | THC | WASP | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 两个杂交 | BioGRID | 9889097 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS | 97 | 71 | 该途径中的所有SZGR 2.0基因 |
| 肌动蛋白细胞骨架的KEGG调节 | 216 | 144 | 该途径中的所有SZGR 2.0基因 |
| KEGG PATHOGENIC ESCHERICHIA COLI INFECTION | 59 | 36 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA SALMONELLA PATHWAY | 13 | 10 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA MPR PATHWAY | 34 | 28 | 该途径中的所有SZGR 2.0基因 |
| Biocarta Rho途径 | 32 | 23 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA CDC42RAC PATHWAY | 16 | 13 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA ACTINY PATHWAY | 20 | 14 | 该途径中的所有SZGR 2.0基因 |
| PID CDC42 PATHWAY | 70 | 51 | 该途径中的所有SZGR 2.0基因 |
| PID ERBB1 DOWNSTREAM PATHWAY | 105 | 78 | 该途径中的所有SZGR 2.0基因 |
| PID PDGFRB PATHWAY | 129 | 103 | 该途径中的所有SZGR 2.0基因 |
| PID RAC1 PATHWAY | 54 | 37 | 该途径中的所有SZGR 2.0基因 |
| Liu Sox4靶向DN | 309 | 191 | 该途径中的所有SZGR 2.0基因 |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | 该途径中的所有SZGR 2.0基因 |
| WANG BARRETTS ESOPHAGUS AND ESOPHAGUS CANCER UP | 26 | 12 | 该途径中的所有SZGR 2.0基因 |
| DAIRKEE TERT TARGETS UP | 380 | 213 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| LOPEZ MBD TARGETS | 957 | 597 | 该途径中的所有SZGR 2.0基因 |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | 该途径中的所有SZGR 2.0基因 |
| HASLINGER B CLL WITH CHROMOSOME 12 TRISOMY | 24 | 12 | 该途径中的所有SZGR 2.0基因 |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | 该途径中的所有SZGR 2.0基因 |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 该途径中的所有SZGR 2.0基因 |
| JIANG HYPOXIA CANCER | 83 | 52 | 该途径中的所有SZGR 2.0基因 |
| KYNG DNA DAMAGE BY 4NQO | 38 | 24 | 该途径中的所有SZGR 2.0基因 |
| KYNG DNA DAMAGE DN | 195 | 135 | 该途径中的所有SZGR 2.0基因 |
| STEARMAN LUNG CANCER EARLY VS LATE UP | 125 | 89 | 该途径中的所有SZGR 2.0基因 |
| BERNARD PPAPDC1B TARGETS UP | 40 | 20 | 该途径中的所有SZGR 2.0基因 |
| GRADE COLON CANCER UP | 871 | 505 | 该途径中的所有SZGR 2.0基因 |
| WEST ADRENOCORTICAL TUMOR UP | 294 | 199 | 该途径中的所有SZGR 2.0基因 |
| MALONEY RESPONSE TO 17AAG UP | 41 | 26 | 该途径中的所有SZGR 2.0基因 |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | 该途径中的所有SZGR 2.0基因 |
| 肌肉中的罗马胰岛素靶标 | 442 | 263 | 该途径中的所有SZGR 2.0基因 |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | 该途径中的所有SZGR 2.0基因 |