SZGR2 - Beplay体育中心

Summary？

基因	10097
象征	ACTR2
Synonyms	ARP2
Description	ARP2肌动蛋白相关蛋白2同源物（酵母）
Reference	MIM:604221\|HGNC：HGNC：169\|ENSEMBL：ENSG00000138071\|HPRD:05023\|Vega：Otthumg00000129540
基因类型	蛋白质编码
Map location	2P14
Pascal p-value	0.77
Sherlock p-value	0.688
胎儿β	0.077
DMG	1(# studies)
主持人	皮质 Frontal Cortex BA9 Myers' cis & trans 元
Support	结构可塑性 G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS CompositeSet

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：JAFFE_2016	全基因组DNA甲基化分析	该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。	1
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息
go_annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
cg14629348	2	65455242	ACTR2	5.88E-9	-0.011	3.16e-6	DMG：JAFFE_2016

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS2105242	CHR1	163568328	ACTR2	10097		0.03		反式
RS7076997	Chr10	134046707	ACTR2	10097		0.08		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
eif4enif1	0.90	0.88
AC020663.1	0.90	0.88
C1orf163	0.90	0.92
PDXDC1	0.89	0.89
Rabgef1	0.89	0.88
heatr5b	0.89	0.91
NHEDC2	0.89	0.87
ALS2	0.89	0.91
bai3	0.89	0.88
MSL1	0.89	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
MT-CO2	-0.84	-0.83
AF347015.31	-0.83	-0.84
AF347015.21	-0.81	-0.84
AF347015.33	-0.80	-0.81
FXYD1	-0.80	-0.81
AF347015.8	-0.80	-0.82
AF347015.27	-0.80	-0.82
mt-cyb	-0.79	-0.80
HIGD1B	-0.79	-0.81
AF347015.2	-0.77	-0.80

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
GO:0003779	actin binding	IEA		-
去：0005515	蛋白质结合	IEA		-
去：0005515	蛋白质结合	IPI		17353931
去：0005524	ATP binding	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0006928	cell motion	TAS		9230079
Cellular component	去学期	证据	神经关键字	PubMed ID
GO：0042995	cell projection	IEA	Axon（GO术语级别：4）	-
去：0005737	cytoplasm	IEA		-
去：0005885	Arp2/3 protein complex	TAS		9230079

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ACTC1	ACTC \| CMD1R \| CMH11	actin, alpha, cardiac muscle 1	-	HPRD,BioGRID	12019562
ACTR3	arp3	ARP3肌动蛋白相关蛋白3同源物（酵母）	共纯化	Biogrid	11741539
ACTR3	arp3	ARP3肌动蛋白相关蛋白3同源物（酵母）	ARP2/3复杂亚基ARP2和ARP3相互作用	绑定	11721045\|11741539
ACTR3B	arp11 \|arp3beta \|DKFZP686O24114	arp3actin-related protein 3 homolog B (yeast)	Affinity Capture-MS	Biogrid	17353931
arpc1b	ARC41 \|p40-arc \|P41-arc	肌动蛋白相关蛋白2/3复合物，亚基1B，41KDA	-	HPRD	9230079\|11721045
arpc1b	ARC41 \|p40-arc \|P41-arc	肌动蛋白相关蛋白2/3复合物，亚基1B，41KDA	ARP2/3复合体亚基P41和ARP2相互作用	绑定	11741539
ARPC2	ARC34 \|PNAS-139 \|Pro2446 \|p34-arc	actin related protein 2/3 complex, subunit 2, 34kDa	-	HPRD	9230079
ARPC3	ARC21 \|p21-arc	肌动蛋白相关蛋白2/3复合物，亚基3，21KDA	-	HPRD	9000076
ARPC4	Arc20 \|MGC13544 \|P20-arc	肌动蛋白相关蛋白2/3复合物，亚基4，20KDA	ARP2/3复合体亚基P20和ARP2相互作用	绑定	11721045\|11741539
ARPC4	Arc20 \|MGC13544 \|P20-arc	肌动蛋白相关蛋白2/3复合物，亚基4，20KDA	-	HPRD	11162547
ARPC5	ARC16 \| MGC88523 \| dJ127C7.3 \| p16-Arc	肌动蛋白相关蛋白2/3复合物，亚基5，16KDA	Arp2/3 complex subunits p16 and Arp2 interact	绑定	11741539
bak1	贝克\|类似bak \|bcl2l7 \|CDN1 \|MGC117255 \|MGC3887	Bcl2-Antagonist/杀手1	Affinity Capture-MS	Biogrid	17353931
BMP2	BMP2A	bone morphogenetic protein 2	重构的复合物	Biogrid	10880444
CTTN	EMS1 \| FLJ34459	cortactin	Affinity Capture-MS	Biogrid	11018051
HCLS1	CTTNL \| HS1	hematopoietic cell-specific Lyn substrate 1	-	HPRD	12534372
IQGAP2	-	含有GTPase激活蛋白2的智商基序2	-	HPRD	12515716
WASF2	SCAR2 \| WAVE2 \| dJ393P12.2	WAS protein family, member 2	-	HPRD	9889097

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
生物卡尔塔沙门氏菌途径	13	10	All SZGR 2.0 genes in this pathway
Biocarta MPR途径	34	28	All SZGR 2.0 genes in this pathway
Biocarta Rho途径	32	23	All SZGR 2.0 genes in this pathway
Biocarta CDC42RAC途径	16	13	All SZGR 2.0 genes in this pathway
Biocarta Actiny Pathway	20.	14	All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS	45	37	All SZGR 2.0 genes in this pathway
Rho GTPases对肌动蛋白细胞骨架的SIG调节	35	25	All SZGR 2.0 genes in this pathway
ST整合素信号通路	82	62	All SZGR 2.0 genes in this pathway
PID CDC42途径	70	51	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID PDGFRB途径	129	103	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn	493	298	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病	1382	904	All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN	460	312	All SZGR 2.0 genes in this pathway
王LMO4目标DN	352	225	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
Hoebeke淋巴干细胞DN	86	59	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
Senese HDAC1靶向	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
Kim WT1靶向DN	459	276	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性	722	443	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP	64	46	All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN	485	334	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
YANAGIHARA ESX1 TARGETS	30	19	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN	514	319	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN	47	33	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络	1442	892	All SZGR 2.0 genes in this pathway
肺癌吸烟者	80	52	All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标	893	528	All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者	555	346	All SZGR 2.0 genes in this pathway
LEI MYB目标	318	215	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
McClung Delta FOSB目标8WK	47	38	All SZGR 2.0 genes in this pathway
阿尔茨海默病DN布莱洛克的	1237	837	All SZGR 2.0 genes in this pathway
麦卡因可卡因奖励5D	79	62	All SZGR 2.0 genes in this pathway
Cheng对醋酸镍的反应	45	29	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
西部肾上腺皮质肿瘤	294	199	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
王肿瘤的侵入性DN	210	128	All SZGR 2.0 genes in this pathway
Mootha PGC	420	269	All SZGR 2.0 genes in this pathway
SPIRA SMOKERS LUNG CANCER UP	38	24	All SZGR 2.0 genes in this pathway
米利假足	518	299	All SZGR 2.0 genes in this pathway
Hoshida肝癌后期复发	62	42	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL UP	73	49	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION	130	87	All SZGR 2.0 genes in this pathway
萨森对促性腺营养蛋白的反应	91	59	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN	88	68	All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up	548	370	All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS	289	187	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
Let-7/98	1650	1656	1a	hsa-let-7a^brain	ugagguaguaguauauaguu
				hsa-let-7b^brain	ugagguaguagguuguguguguu
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	ugagguaggagguuauauagu
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	ugagguaaguuguauuguu
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	ugagguaguugugugugugcugu
miR-15/16/195/424/497	235	241	M8	HSA-MIR-15A^brain	uagcagcacauaugguugug
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
				HSA-MIR-15A^brain	uagcagcacauaugguugug
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
miR-24*	255	261	M8	HSA-MIR-189	Gugccuacugagagauaucagu
mir-338	1681	1688	1A，M8	hsa-miR-338^brain	uccagauuuuuguuga
mir-503	309	315	1a	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:ACTR2