Gene Page:CDH12

Summary?
GeneID 1010
Symbol CDH12
Synonyms CDHB
Description cadherin 12
Reference MIM:600562|HGNC:HGNC:1751|Ensembl:ENSG00000154162|HPRD:11081|Vega:OTTHUMG00000090591
Gene type protein-coding
Map location 5p14.3
Pascal p-value 0.579
Sherlock p-value 0.414
Fetal beta -0.646
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Support CELL ADHESION AND TRANSSYNAPTIC SIGNALING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-occ基因urring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg17533522 5 22212932 CDH12 8.26E-5 0.401 0.026 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C21orf29 0.37 0.23
SCN4A 0.35 0.20
WDR87 0.35 0.26
PKD1L3 0.33 0.31
GPR133 0.32 0.21
SVOPL 0.32 0.23
AHNAK2 0.32 0.32
RP11-413E6.1 0.32 0.18
OC90 0.32 0.17
ACSM1 0.32 0.17
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.2 -0.27 -0.32
CXCL14 -0.27 -0.31
HIGD1B -0.27 -0.35
OAF -0.27 -0.33
AF347015.33 -0.26 -0.30
MT-CO2 -0.26 -0.31
ADA -0.26 -0.28
ACSF2 -0.26 -0.30
AF347015.31 -0.26 -0.31
AC021016.1 -0.26 -0.30

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME CELL CELL COMMUNICATION 120 77 All SZGR 2.0 genes in this pathway
REACTOME ADHERENS JUNCTIONS INTERACTIONS 27 20 All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 56 31 All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 78 43 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN 123 78 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245 144 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295 149 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3 206 108 All SZGR 2.0 genes in this pathway
KYNG NORMAL AGING DN 30 13 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM DN 29 14 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 All SZGR 2.0 genes in this pathway