Gene Page:ARPC2

Summary?
GeneID 10109
Symbol ARPC2
Synonyms ARC34|PNAS-139|PRO2446|p34-Arc
Description actin related protein 2/3 complex subunit 2
Reference MIM:604224|HGNC:HGNC:705|Ensembl:ENSG00000163466|HPRD:10367|Vega:OTTHUMG00000133618
Gene type protein-coding
Map location 2q36.1
Pascal p-value 0.706
Sherlock p-value 0.349
Fetal beta -0.001
DMG 1 (# studies)
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00916
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08216808 2 219081385 ARPC2 2.281E-4 0.436 0.036 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003779 actin binding IEA -
GO:0005515 protein binding 新闻学会 17350576|17353931
GO:0005200 structural constituent of cytoskeleton TAS 9230079
生物process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006928 cell motion TAS 9230079
GO:0030833 regulation of actin filament polymerization IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0042995 cell projection IEA axon (GO term level: 4) -
GO:0005856 cytoskeleton IEA -
GO:0005737 cytoplasm IEA -
GO:0005885 Arp2/3 protein complex TAS 9230079

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
KEGG调节肌动蛋白细胞骨架 216 144 All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 59 36 All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY 13 10 All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY 34 28 All SZGR 2.0 genes in this pathway
BIOCARTA RHO PATHWAY 32 23 All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY 16 13 All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY 20 14 All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 70 51 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 54 37 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP 112 71 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186 114 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 73 51 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
VETTER TARGETS OF PRKCA AND ETS1 DN 16 10 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
LIU NASOPHARYNGEAL CARCINOMA 70 38 All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION L0 L1 DN 21 14 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 33 21 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246 152 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS 78 49 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 All SZGR 2.0 genes in this pathway
金所有障碍少突细胞麻木ER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 146 90 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN 92 60 All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE ALL DN 11 8 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-25/32/92/363/367 300 306 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-382 224 230 1A hsa-miR-382brain GAAGUUGUUCGUGGUGGAUUCG
miR-544 147 154 1A,m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU