Gene Page:ACTR1B
Summary?
| GeneID | 10120 |
| Symbol | ACTR1B |
| Synonyms | ARP1B|CTRN2|PC3 |
| Description | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) |
| Reference | MIM:605144|HGNC:HGNC:168|Ensembl:ENSG00000115073|HPRD:05508|Vega:OTTHUMG00000130549 |
| Gene type | protein-coding |
| Map location | 2q11.2 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.92 |
| eGene | Cerebellar Hemisphere Cerebellum Myers' cis & trans |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0004 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs621071 | chr1 | 182682810 | ACTR1B | 10120 | 0.05 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC100793.2 | 0.73 | 0.66 |
| SLC38A5 | 0.73 | 0.75 |
| NODAL | 0.72 | 0.73 |
| ECSCR | 0.72 | 0.65 |
| C1orf86 | 0.71 | 0.69 |
| PHPT1 | 0.71 | 0.64 |
| NPB | 0.70 | 0.55 |
| RSPH9 | 0.70 | 0.59 |
| AC006276.2 | 0.70 | 0.67 |
| PVRL2 | 0.69 | 0.70 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL2L2 | -0.50 | -0.55 |
| CCDC25 | -0.50 | -0.61 |
| WASF3 | -0.50 | -0.59 |
| C7orf41 | -0.50 | -0.59 |
| RAPGEF4 | -0.50 | -0.51 |
| CDH18 | -0.49 | -0.56 |
| HABP4 | -0.49 | -0.53 |
| ANKRD40 | -0.49 | -0.57 |
| CBX7 | -0.48 | -0.54 |
| C6orf106 | -0.48 | -0.54 |
Section III. Gene Ontology annotation
| Molecular function | 去后m | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0005515 | protein binding | 新闻学会 | 12857853 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0005198 | structural molecule activity | IEA | - | |
| Cellular component | 去后m | Evidence | Neuro keywords | PubMed ID |
| GO:0005813 | centrosome | IEA | - | |
| GO:0005856 | cytoskeleton | IEA | - | |
| GO:0005869 | dynactin complex | TAS | 7696711 | |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME MHC CLASS II ANTIGEN PRESENTATION | 91 | 61 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME适应性免疫系统 | 539 | 350 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS FETAL LIVER DN | 514 | 319 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| WELCSH BRCA1 TARGETS UP | 198 | 132 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT DN | 165 | 106 | All SZGR 2.0 genes in this pathway |
| KAYO CALORIE RESTRICTION MUSCLE UP | 95 | 64 | All SZGR 2.0 genes in this pathway |
| LEE AGING MUSCLE UP | 45 | 33 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS CALB1 CORR UP | 548 | 370 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |
| VANOEVELEN MYOGENESIS SIN3A TARGETS | 220 | 133 | All SZGR 2.0 genes in this pathway |