Gene Page:DNAL4
Summary?
| GeneID | 10126 |
| Symbol | DNAL4 |
| Synonyms | MRMV3|PIG27 |
| Description | 动力蛋白axonemal轻链4 |
| Reference | MIM:610565|HGNC:HGNC:2955|Ensembl:ENSG00000100246|HPRD:13239|Vega:OTTHUMG00000151025 |
| Gene type | protein-coding |
| Map location | 22q13.1 |
| Pascal p-value | 0.008 |
| Sherlock p-value | 0.3 |
| eGene | Myers' cis & trans 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12302525 | chr12 | 89726424 | DNAL4 | 10126 | 0.08 | trans | ||
| rs8097646 | chr18 | 55008905 | DNAL4 | 10126 | 0.07 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TMEM175 | 0.66 | 0.65 |
| PNPLA2 | 0.64 | 0.63 |
| SLC39A13 | 0.64 | 0.65 |
| MIB2 | 0.63 | 0.64 |
| ARSA | 0.62 | 0.65 |
| SHC2 | 0.62 | 0.65 |
| CEMP1 | 0.62 | 0.61 |
| DUS1L | 0.62 | 0.62 |
| TMEM129 | 0.61 | 0.59 |
| AMDHD2 | 0.61 | 0.60 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SEC62 | -0.29 | -0.30 |
| AC114744.1 | -0.26 | -0.16 |
| CLEC2B | -0.25 | -0.15 |
| AF347015.21 | -0.25 | -0.17 |
| RSL24D1 | -0.25 | -0.18 |
| FAM159B | -0.25 | -0.29 |
| EIF3E | -0.25 | -0.12 |
| AC008865.3 | -0.25 | -0.12 |
| CBWD1 | -0.24 | -0.23 |
| AL391152.1 | -0.24 | -0.17 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG HUNTINGTONS DISEASE | 185 | 109 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | All SZGR 2.0 genes in this pathway |
| REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | 13 | 7 | All SZGR 2.0 genes in this pathway |
| SCIBETTA KDM5B TARGETS UP | 19 | 12 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| AIYAR COBRA1 TARGETS UP | 39 | 25 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |