Gene Page:BCAP31
Summary?
| GeneID | 10134 |
| Symbol | BCAP31 |
| Synonyms | 6C6-AG|BAP31|CDM|DDCH|DXS1357E |
| Description | B-cell receptor-associated protein 31 |
| Reference | MIM:300398|HGNC:HGNC:16695|Ensembl:ENSG00000185825|HPRD:02319|Vega:OTTHUMG00000024218 |
| Gene type | protein-coding |
| Map location | Xq28 |
| Sherlock p-value | 0.988 |
| Fetal beta | -0.763 |
| Support | RNA AND PROTEIN SYNTHESIS Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| THAP11 | 0.93 | 0.94 |
| DCAKD | 0.93 | 0.92 |
| MED16 | 0.92 | 0.91 |
| RIC8A | 0.91 | 0.92 |
| GGA1 | 0.91 | 0.92 |
| E4F1 | 0.91 | 0.90 |
| SCAP | 0.91 | 0.91 |
| MED22 | 0.91 | 0.91 |
| ZNF574 | 0.91 | 0.91 |
| FPGS | 0.91 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.72 | -0.84 |
| MT-CO2 | -0.71 | -0.82 |
| AF347015.31 | -0.71 | -0.81 |
| AF347015.8 | -0.70 | -0.83 |
| AF347015.33 | -0.70 | -0.80 |
| MT-CYB | -0.68 | -0.80 |
| AF347015.21 | -0.67 | -0.85 |
| AF347015.15 | -0.66 | -0.79 |
| AF347015.2 | -0.64 | -0.78 |
| AF347015.26 | -0.64 | -0.78 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005102 | receptor binding | NAS | Neurotransmitter (GO term level: 4) | - |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006955 | immune response | NAS | - | |
| GO:0006915 | apoptosis | IEA | - | |
| GO:0006886 | intracellular protein transport | IEA | - | |
| GO:0016192 | vesicle-mediated transport | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0000139 | Golgi membrane | IEA | - | |
| GO:0005789 | endoplasmic reticulum membrane | IEA | - | |
| GO:0005783 | endoplasmic reticulum | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | IDA | 8706661 | |
| GO:0033116 | ER-Golgi intermediate compartment membrane | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ACTG1 | ACT | ACTG | DFNA20 | DFNA26 | actin, gamma 1 | - | HPRD,BioGRID | 10958671 |
| 应用程序 | AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 | amyloid beta (A4) precursor protein | - | HPRD,BioGRID | 12529377 |
| BCAP29 | BAP29 | DKFZp686M2086 | B-cell receptor-associated protein 29 | - | HPRD,BioGRID | 12886015 |
| BCAP31 | 6C6-AG | BAP31 | CDM | DXS1357E | B-cell receptor-associated protein 31 | - | HPRD,BioGRID | 12886015 |
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | - | HPRD,BioGRID | 9334338 |
| BCL2L1 | BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS | BCL2-like 1 | - | HPRD,BioGRID | 9334338 |
| CANX | CNX | FLJ26570 | IP90 | P90 | calnexin | - | HPRD | 11851433 |
| CASP1 | ICE | IL1BC | P45 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | - | HPRD,BioGRID | 9334338 |
| CASP8 | ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473 | caspase 8, apoptosis-related cysteine peptidase | - | HPRD,BioGRID | 9334338 |
| IGHD | FLJ00382 | FLJ46727 | MGC29633 | immunoglobulin heavy constant delta | - | HPRD | 12886015 |
| MYH10 | MGC134913 | MGC134914 | NMMHCB | myosin, heavy chain 10, non-muscle | - | HPRD,BioGRID | 10958671 |
| PLP2 | A4 | A4-LSB | MGC126187 | proteolipid protein 2 (colonic epithelium-enriched) | - | HPRD | 12529377 |
| PTPLB | - | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b | BAP31 interacts with PTPLB. | BIND | 15024066 |
| VAMP2 | FLJ11460 | SYB2 | VAMP-2 | vesicle-associated membrane protein 2 (synaptobrevin 2) | Reconstituted Complex | BioGRID | 9396746 |
| VAMP3 | CEB | vesicle-associated membrane protein 3 (cellubrevin) | - | HPRD,BioGRID | 9396746 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | 40 | 26 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOSIS | 148 | 94 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOTIC EXECUTION PHASE | 54 | 37 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| 城堡内成神经管细胞瘤DESMOPLASIC VS经典 | 62 | 38 | All SZGR 2.0 genes in this pathway |
| LIN APC TARGETS | 77 | 55 | All SZGR 2.0 genes in this pathway |
| NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP | 157 | 105 | All SZGR 2.0 genes in this pathway |
| KLEIN PRIMARY EFFUSION LYMPHOMA UP | 51 | 29 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE DN | 245 | 154 | All SZGR 2.0 genes in this pathway |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | All SZGR 2.0 genes in this pathway |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
| BURTON ADIPOGENESIS 5 | 126 | 78 | All SZGR 2.0 genes in this pathway |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| WORSCHECH TUMOR REJECTION DN | 10 | 6 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS DN | 145 | 93 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 UP | 338 | 225 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF UP | 418 | 282 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G6 UP | 65 | 43 | All SZGR 2.0 genes in this pathway |
| KESHELAVA MULTIPLE DRUG RESISTANCE | 88 | 56 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL IL3RA | 9 | 6 | All SZGR 2.0 genes in this pathway |
| 金所有障碍少突细胞麻木ER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS DURATION CORR DN | 146 | 90 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |