基因页：ABI2
概括?
| 基因ID | 10152 |
| Symbol | ABI2 |
| 同义词 | ABI-2|ABI2B|AIP-1|AblBP3|SSH3BP2|argBP1|argBPIA|argBPIB |
| 描述 | abl-interactor 2 |
| 参考 | MIM：606442|HGNC:HGNC:24011|Ensembl:ENSG00000138443|Vega:OTTHUMG00000132879 |
| 基因type | protein-coding |
| 地图位置 | 2q33 |
| Pascal P值 | 0.053 |
| Sherlock P值 | 0.697 |
| Fetal beta | 0.419 |
| DMG | 1（＃研究） |
| 支持 | STRUCTURAL PLASTICITY COMPOSITESET |
数据源中的基因
| 基因集名称 | 基因组方法 | 描述 | Info |
|---|---|---|---|
| 简历：PGCNP | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 3 | |
| 网络 | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | Contribution to shortest path in PPI network: 0.0043 |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| 探测 | Chromosome | Position | Nearest gene | P (dis) | beta（dis） | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg05462826 | 2 | 204193327 | ABI2 | -0.021 | 0.34 | DMG:Nishioka_2013 |
Section II. Transcriptome annotation
基因ral gene expression (GTEx)
基因expression during devlopment (BrainCloud)
脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。
基因expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| 基因 | Pearson's Correlation | Spearman's Correlation |
| HeaTr2 | 0.87 | 0.82 |
| LLGL1 | 0.86 | 0.85 |
| SCRIB | 0.86 | 0.81 |
| 语无伦次地说R1 | 0.86 | 0.83 |
| PTBP1 | 0.86 | 0.82 |
| ZNF219 | 0.85 | 0.73 |
| ZNF687 | 0.85 | 0.83 |
| AL161668.2 | 0.85 | 0.79 |
| ZNF516 | 0.84 | 0.82 |
| TCF3 | 0.84 | 0.76 |
| 前10个负共表达基因 | ||
| 基因 | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.52 | -0.52 |
| SYCP3 | -0.51 | -0.60 |
| AF347015.31 | -0.48 | -0.53 |
| AF347015.21 | -0.47 | -0.60 |
| C1orf54 | -0.47 | -0.52 |
| CLEC2B | -0.46 | -0.57 |
| 卡16 | -0.46 | -0.56 |
| LY96 | -0.45 | -0.54 |
| RERGL | -0.45 | -0.57 |
| AL050337.1 | -0.44 | -0.52 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003674 | molecular_function | ND | - | |
| GO:0003677 | DNA binding | 塔斯 | 7590236 | |
| GO:0005070 | SH3/SH2 adaptor activity | 塔斯 | 7590236 | |
| GO:0017124 | SH3 domain binding | 塔斯 | 8649853 | |
| 去：0008093 | cytoskeletal adaptor activity | 塔斯 | 12011975 | |
| GO:0019900 | 激酶结合 | NAS | 8649853 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0016358 | dendrite development | IEA | neurite, dendrite (GO term level: 11) | - |
| GO:0007010 | cytoskeleton organization | 塔斯 | 12011975 | |
| GO:0008150 | 生物_Process | ND | - | |
| GO:0008154 | actin polymerization or depolymerization | NAS | 11516653 | |
| GO:0007611 | learning or memory | IEA | - | |
| 去：0006928 | cell motion | NAS | 11516653 | |
| GO:0018108 | 肽基 - 酪氨酸磷酸化 | IDA | 17101133 | |
| GO:0016477 | 细胞迁移 | IEA | - | |
| GO:0016477 | 细胞迁移 | 塔斯 | 12011975 | |
| GO:0043010 | 相机型眼睛开发 | IEA | - | |
| 细胞分量 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0030175 | filopodium | NAS | axon (GO term level: 5) | 11516653 |
| GO:0030425 | dendrite | IEA | neuron, axon, dendrite (GO term level: 6) | - |
| 去：0005829 | cytosol | IDA | 17101133 | |
| GO:0005856 | cytoskeleton | IEA | - | |
| GO:0005737 | 细胞质 | NAS | 8649853 | |
| GO:0005737 | 细胞质 | 塔斯 | 8649853 | |
| GO:0030027 | 薄片 | NAS | 11516653 | |
| 去：0005913 | cell-cell adherens junction | IEA | - |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD，Biogrid | 7590236 |
| ADAM19 | FKSG34 | MADDAM | MLTNB | ADAM metallopeptidase domain 19 (meltrin beta) | ADAM19interacts with ArgBP1. This interaction was modelled on a demonstrated interaction between mouse ADAM19 and human ArgBP1. | BIND | 12463424 |
| CCDC53 | CGI-116 | 包含53 | 两个杂交 | BioGRID | 16189514 |
| IFT20 | - | intraflagellar transport 20 homolog (Chlamydomonas) | 两个杂交 | BioGRID | 16189514 |
| KRT15 | CK15 | K15 | K1CO | keratin 15 | 两个杂交 | BioGRID | 16189514 |
| KRT19 | CK19 | K19 | K1CS | MGC15366 | keratin 19 | 两个杂交 | BioGRID | 16189514 |
| KRT20 | CD20 | CK20 | K20 | KRT21 | MGC35423 | keratin 20 | 两个杂交 | BioGRID | 16189514 |
| NCK2 | GRB4 | NCKbeta | NCK适配器蛋白2 | 两个杂交 | BioGRID | 16189514 |
| PCM1 | PTC4 | pericentriolar material 1 | 两个杂交 | BioGRID | 16189514 |
| SH3KBP1 | CIN85 |gig10 |MIG18 | SH3-domain kinase binding protein 1 | - | HPRD，Biogrid | 10858458 |
| SNAP23 | HsT17016 | SNAP23A | SNAP23B | synaptosomal-associated protein, 23kDa | 两个杂交 | BioGRID | 16189514 |
| VCL | CMD1W | MVCL | vinculin | 两个杂交 | BioGRID | 16189514 |
| VPS37C | FLJ20847 | vacuolar protein sorting 37 homolog C (S. cerevisiae) | - | HPRD | 15509564 |
V.途径注释
| Pathway name | Pathway size | ＃szgr 2.0基因 | Info |
|---|---|---|---|
| KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA ACTINY PATHWAY | 20 | 14 | 该途径中的所有SZGR 2.0基因 |
| PID Rac1途径 | 54 | 37 | 该途径中的所有SZGR 2.0基因 |
| Chandran转移Top50 dn | 45 | 26 | 该途径中的所有SZGR 2.0基因 |
| WANG CLIM2 TARGETS UP | 269 | 146 | 该途径中的所有SZGR 2.0基因 |
| runx1 runx1t1融合HSC的TONKS目标UP | 185 | 126 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | 该途径中的所有SZGR 2.0基因 |
| SCHRAMM INHBA TARGETS DN | 24 | 12 | 该途径中的所有SZGR 2.0基因 |
| WOOD EBV EBNA1 TARGETS UP | 110 | 71 | 该途径中的所有SZGR 2.0基因 |
| Nuytten EZH2靶向DN | 1024 | 594 | 该途径中的所有SZGR 2.0基因 |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | 236 | 139 | 该途径中的所有SZGR 2.0基因 |
| 里克曼转移 | 344 | 180 | 该途径中的所有SZGR 2.0基因 |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR DN | 428 | 306 | 该途径中的所有SZGR 2.0基因 |
| SMITH TERT TARGETS UP | 145 | 91 | 该途径中的所有SZGR 2.0基因 |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | 该途径中的所有SZGR 2.0基因 |
| lu衰老的脑dn | 153 | 120 | 该途径中的所有SZGR 2.0基因 |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | 该途径中的所有SZGR 2.0基因 |
| BILD CTNNB1致癌特征 | 82 | 52 | 该途径中的所有SZGR 2.0基因 |
| Creighton内分泌疗法抗性1 | 528 | 324 | 该途径中的所有SZGR 2.0基因 |
| AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G | 95 | 62 | 该途径中的所有SZGR 2.0基因 |
| Yoshimura mapk8靶向 | 1305 | 895 | 该途径中的所有SZGR 2.0基因 |
| 陈代谢综合征网络 | 1210 | 725 | 该途径中的所有SZGR 2.0基因 |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | 该途径中的所有SZGR 2.0基因 |
| KYNG RESPONSE TO H2O2 VIA ERCC6 UP | 40 | 30 | 该途径中的所有SZGR 2.0基因 |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | 该途径中的所有SZGR 2.0基因 |
| LINSLEY MIR16 TARGETS | 206 | 127 | 该途径中的所有SZGR 2.0基因 |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | 该途径中的所有SZGR 2.0基因 |
| VANOEVELEN MYOGENESIS SIN3A TARGETS | 220 | 133 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
| miRNA family | Target position | mirna id | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-101 | 333 | 339 | 1A | HSA-MIR-101 | UACAGUACUGUGAUAACUGAAG |
| mir-134 | 1003 | 1009 | m8 | hsa - mir - 134脑 | UGUGACUGGUUGACCAGAGGG |
| mir-144 | 332 | 339 | 1A,m8 | hsa-miR-144 | uacaguauagauguauguaguag |
| mir-186 | 3993 | 3999 | 1A | hsa-miR-186 | CAAAGAAUUCUCCUUUUGGGCUU |
| mir-378 | 326 | 332 | 1A | hsa - mir - 378 | cuccugacuccaggucugugu |
| miR-539 | 350 | 356 | m8 | HSA-MIR-539 | ggagaauuauccuuggugugu |
| miR-544 | 361 | 367 | m8 | HSA-MIR-544 | AUUCUGCAUUUUUAGCAAGU |