Gene Page:CDH18

Summary?
GeneID 1016
Symbol CDH18
Synonyms CDH14|CDH14L|CDH24
Description cadherin 18
Reference MIM:603019|HGNC:HGNC:1757|Ensembl:ENSG00000145526|HPRD:04314|Vega:OTTHUMG00000090578
Gene type protein-coding
Map location 5p14.3
Pascal p-value 0.109
Sherlock p-value 0.95
Fetal beta -2.191
DMG 1 (# studies)
eGene Myers' cis & trans
Support CELL ADHESION AND TRANSSYNAPTIC SIGNALING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg24106898 5 19892970 CDH18 1.601E-4 0.436 0.032 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10472832 chr5 19087341 CDH18 1016 0.16 cis
rs586290 chr5 19479745 CDH18 1016 0.18 cis
rs16955618 chr15 29937543 CDH18 1016 0.04 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
E2F2 0.78 0.27
SP1 0.77 0.79
ARHGAP19 0.76 0.70
KIAA1958 0.76 0.71
BRCA1 0.74 0.74
MYBL1 0.74 0.70
C19orf31 0.74 0.33
NCAPD2 0.74 0.69
LIMD1 0.74 0.60
ZNF367 0.73 0.59
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.31 -0.40
CXCL14 -0.31 -0.40
CLDND2 -0.31 -0.44
IL32 -0.30 -0.50
SYCP3 -0.30 -0.42
C1orf54 -0.29 -0.40
IFI27 -0.29 -0.35
AC044839.2 -0.28 -0.38
AF347015.31 -0.28 -0.33
MYL3 -0.28 -0.34

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME CELL CELL COMMUNICATION 120 77 All SZGR 2.0 genes in this pathway
REACTOME ADHERENS JUNCTIONS INTERACTIONS 27 20 All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 56 31 All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 78 43 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE DN 67 46 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 71 49 All SZGR 2.0 genes in this pathway
金所有障碍和少突细胞数量R UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway