Gene Page:SORBS3

概括?
基因 10174
象征 SORBS3
Synonyms SCAM-1|SCAM1|SH3D4
Description sorbin and SH3 domain containing 3
Reference MIM:610795|HGNC:HGNC:30907|Ensembl:ENSG00000120896|HPRD：11535|Vega:OTTHUMG00000131728
Gene type protein-coding
Map location 8p21.3
Pascal p-value 0.006
Sherlock p-value 0.291
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.031
GSMA_IIE 基因组扫描荟萃分析（欧洲官方样品） Psr: 0.00057
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.03086
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 0.024

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9878437 chr3 60321270 SORBS3 10174 0.19 trans
rs16955618 chr15 29937543 SORBS3 10174 0 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EBF1 0.96 0.46
PBX3 0.92 0.52
NTN1 0.90 0.51
ZNF503 0.89 0.46
C10orf41 0.89 0.31
RARB 0.88 0.37
AC010997.1 0.88 0.46
ZNF521 0.88 0.55
AC134043.1 0.87 0.22
SERTAD4 0.87 0.47
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CDADC1 -0.21 0.07
chpt1 -0.21 -0.12
INPP1 -0.21 -0.01
C5orf53 -0.18 -0.30
PTH1R -0.18 -0.21
C1 -0.18 0.03
TMEM54 -0.17 -0.13
PPP2R5A -0.17 0.17
COPZ2 -0.17 -0.25
BLVRB -0.17 -0.04

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005200 structural constituent of cytoskeleton TAS 9885244
GO:0008134 transcription factor binding IEA -
GO:0017166 vinculin binding 新闻学会 9885244
生物过程 GO term Evidence Neuro keywords PubMed ID
GO：0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
GO:0031589 cell-substrate adhesion IEA -
GO:0043410 positive regulation of MAPKKK cascade IEA -
GO:0051495 positive regulation of cytoskeleton organization NAS 9885244
GO:0051496 positive regulation of stress fiber formation IDA 9885244
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton IEA -
GO:0005634 nucleus IEA -
GO:0005737 细胞质 IEA -
去：0005925 focal adhesion IDA 9885244
去：0005925 focal adhesion IEA -
GO:0030054 细胞连接 IEA -

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
ADAMTSL4 TSRC1 ADAMTS-like 4 两个杂交 BioGRID 16189514
CBLB DKFZP686J10223 |DKFZP779A0729 |DKFZP779F1443 |FLJ36865 |FLJ41152 |NBLA00127 |RNF56 Cas-Br-M (murine) ecotropic retroviral transforming sequence b 两个杂交 BioGRID 16189514
DDX17 DKFZp761H2016 | P72 | RH70 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 两个杂交 BioGRID 16189514
DLG5 KIAA0583 | LP-DLG | P-DLG5 | PDLG discs, large homolog 5 (Drosophila) - HPRD,BioGRID 12657639
DMRTB1 - DMRT-like family B with proline-rich C-terminal, 1 两个杂交 BioGRID 16189514
DVL2 - dishevelled, dsh homolog 2 (Drosophila) 两个杂交 BioGRID 16189514
EFS CAS3 | CASS3 | EFS1 | EFS2 | HEFS | SIN embryonal Fyn-associated substrate 两个杂交 BioGRID 16189514
FLJ12529 FLJ39024 | MGC9315 pre-mRNA cleavage factor I, 59 kDa subunit 两个杂交 BioGRID 16189514
FLOT1 - flotillin 1 Reconstituted Complex BioGRID 11481476
HNRNPK CSBP | FLJ41122 | HNRPK | TUNP heterogeneous nuclear ribonucleoprotein K 两个杂交 BioGRID 16189514
KIAA0408 FLJ43995 |RP3-403A15.2 KIAA0408 两个杂交 BioGRID 16189514
KIAA1217 DKFZp761L0424 | MGC31990 | SKT KIAA1217 两个杂交 BioGRID 16189514
MAPK1 ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk mitogen-activated protein kinase 1 Affinity Capture-Western
Biochemical Activity		 BioGRID 15184391
MAPK3 ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 mitogen-activated protein kinase 3 - HPRD 15184391
RBMX hnrpg |RBMXP1 |RBMXRT |RNMX |hnrnp-g RNA结合基序蛋白，X连锁 两个杂交 BioGRID 16189514
SAFB2 KIAA0138 scaffold attachment factor B2 - HPRD,BioGRID 12660241
ZBED1 ALTE | DREF | KIAA0785 | TRAMP | hDREF zinc finger, BED-type containing 1 两个杂交 BioGRID 16189514
ZBTB25 KUP | ZNF46 zinc finger and BTB domain containing 25 两个杂交 BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
反应组肌肉收缩 48 24 该途径中的所有SZGR 2.0基因
REACTOME SMOOTH MUSCLE CONTRACTION 25 14 该途径中的所有SZGR 2.0基因
Liu Sox4靶向DN 309 191 该途径中的所有SZGR 2.0基因
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 77 46 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE KERATINOCYTE UP 530 342 该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS DN 848 527 该途径中的所有SZGR 2.0基因
AMIT EGF RESPONSE 480 HELA 164 118 该途径中的所有SZGR 2.0基因
AMIT SERUM RESPONSE 20 MCF10A 21 10 该途径中的所有SZGR 2.0基因
LIN APC TARGETS 77 55 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
NADLER HYPERGLYCEMIA AT OBESITY 58 35 该途径中的所有SZGR 2.0基因
PARK HSC AND MULTIPOTENT PROGENITORS 50 33 该途径中的所有SZGR 2.0基因
LOPES METHYLATED IN COLON CANCER DN 28 26 该途径中的所有SZGR 2.0基因
WEST ADRENOCORTICAL TUMOR DN 546 362 该途径中的所有SZGR 2.0基因
VALK AML CLUSTER 10 33 22 该途径中的所有SZGR 2.0基因
VALK AML WITH EVI1 25 15 该途径中的所有SZGR 2.0基因
DASU IL6 SIGNALING UP 59 44 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
KRIEG HYPOXIA NOT VIA KDM3A 770 480 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-9 407 413 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA