Gene Page:TENM1

Summary?
GeneID 10178
Symbol TENM1
Synonyms ODZ1|ODZ3|TEN-M1|TNM|TNM1
Description teneurin transmembrane protein 1
Reference MIM:300588|HGNC:HGNC:8117|Ensembl:ENSG00000009694|HPRD:06669|Vega:OTTHUMG00000022721
Gene type protein-coding
Map location Xq25

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
TENM1 chrX 123526073 C T NM_001163278
NM_001163279
NM_014253		 p.1839W>*
p.1838W>*
p.1832W>*		 nonsense
nonsense
nonsense		 Schizophrenia DNM:Gulsuner_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM20A 0.84 0.48
AC079210.1 0.84 0.51
GRID2IP 0.81 0.59
NEXN 0.81 -0.04
RGS16 0.80 0.17
CARD11 0.80 -0.08
ATP2A3 0.80 0.38
RGS3 0.79 0.21
CCDC136 0.79 0.41
FAM19A4 0.79 -0.17
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CXCL14 -0.30 -0.68
SPARCL1 -0.30 -0.56
OAF -0.29 -0.71
TNFSF12 -0.27 -0.61
GRASP -0.27 -0.55
RLBP1 -0.27 -0.67
COX4I2 -0.27 -0.69
SERTAD1 -0.27 -0.63
AF347015.2 -0.26 -0.70
ITPKA -0.26 -0.57

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008201 heparin binding TAS 10341219
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development TAS neurite (GO term level: 5) 10341219
GO:0007165 signal transduction IEA -
GO:0008285 negative regulation of cell proliferation TAS 10556288
GO:0006955 immune response TAS 10556288
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region TAS 10341219
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 2399 2405 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-149 1573 1579 m8 hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-153 1726 1732 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d 2445 2451 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-186 1654 1660 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-190 114 120 m8 hsa-miR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-196 1668 1674 1A hsa-miR-196a UAGGUAGUUUCAUGUUGUUGG
hsa-miR-196b UAGGUAGUUUCCUGUUGUUGG
miR-200bc/429 212 218 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 1205 1212 1A,m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-23 133 139 m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-323 133 139 1A hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-329 673 679 1A hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-34/449 432 438 1A hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-34b 123 129 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p 2427 2434 1A,m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 2428 2434 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-378 2436 2442 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-410 815 821 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-448 1725 1732 1A,m8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-495 162 168 m8 hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-496 95 101 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-505 2060 2066 1A hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
miR-539 806 813 1A,m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
miR-544 996 1003 1A,m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU
miR-9 25 32 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA