Gene Page:CDK3

Summary?
GeneID 1018
Symbol CDK3
Synonyms -
Description cyclin-dependent kinase 3
Reference MIM:123828|HGNC:HGNC:1772|Ensembl:ENSG00000250506|Ensembl:ENSG00000261408|HPRD:00446|Vega:OTTHUMG00000154861
Gene type protein-coding
Map location 17q25.1
Pascal p-value 0.04
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia

Gene in Data Sources
Gene set name Method of gene set Description Info
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs12945114 17 73993546 CDK3 ENSG00000250506.2 7.319E-8 0 -3441 gtex_brain_ba24
rs3760131 17 73996887 CDK3 ENSG00000250506.2 7.324E-8 0 -100 gtex_brain_ba24
rs2069528 17 73997474 CDK3 ENSG00000250506.2 7.319E-8 0 487 gtex_brain_ba24
rs2069536 17 74001106 CDK3 ENSG00000250506.2 7.305E-8 0 4119 gtex_brain_ba24
rs1135531 17 74002056 CDK3 ENSG00000250506.2 7.319E-8 0 5069 gtex_brain_ba24
rs11870342 17 74009047 CDK3 ENSG00000250506.2 5.603E-7 0 12060 gtex_brain_ba24
rs2665993 17 74009211 CDK3 ENSG00000250506.2 4.747E-8 0 12224 gtex_brain_ba24
rs2665971 17 74010038 CDK3 ENSG00000250506.2 2.452E-7 0 13051 gtex_brain_ba24
rs2598418 17 74012859 CDK3 ENSG00000250506.2 6.562E-8 0 15872 gtex_brain_ba24
rs2071194 17 74014468 CDK3 ENSG00000250506.2 2.723E-7 0 17481 gtex_brain_ba24
rs2071192 17 74014668 CDK3 ENSG00000250506.2 2.75E-7 0 17681 gtex_brain_ba24
rs2244377 17 74015354 CDK3 ENSG00000250506.2 4.665E-7 0 18367 gtex_brain_ba24
rs2244371 17 74015590 CDK3 ENSG00000250506.2 4.58E-7 0 18603 gtex_brain_ba24
rs2244370 17 74015595 CDK3 ENSG00000250506.2 4.959E-7 0 18608 gtex_brain_ba24
rs2665967 17 74016834 CDK3 ENSG00000250506.2 3.341E-7 0 19847 gtex_brain_ba24
rs2598417 17 74018655 CDK3 ENSG00000250506.2 6.387E-7 0 21668 gtex_brain_ba24
rs12945114 17 73993546 CDK3 ENSG00000250506.2 1.625E-7 0 -3441 gtex_brain_putamen_basal
rs3760131 17 73996887 CDK3 ENSG00000250506.2 1.578E-7 0 -100 gtex_brain_putamen_basal
rs2069528 17 73997474 CDK3 ENSG00000250506.2 1.625E-7 0 487 gtex_brain_putamen_basal
rs2069536 17 74001106 CDK3 ENSG00000250506.2 1.668E-7 0 4119 gtex_brain_putamen_basal
rs1135531 17 74002056 CDK3 ENSG00000250506.2 1.619E-7 0 5069 gtex_brain_putamen_basal
rs2598418 17 74012859 CDK3 ENSG00000250506.2 2.159E-6 0 15872 gtex_brain_putamen_basal
rs2598417 17 74018655 CDK3 ENSG00000250506.2 1.776E-6 0 21668 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ARG2 0.91 0.92
C1orf149 0.91 0.92
TARS 0.90 0.91
DR1 0.90 0.90
SNX4 0.90 0.93
STX7 0.90 0.92
BFAR 0.90 0.92
ACTR3 0.89 0.93
ARMCX1 0.89 0.92
CCT6A 0.89 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.72 -0.86
FXYD1 -0.71 -0.87
AF347015.33 -0.71 -0.86
AF347015.31 -0.71 -0.85
AF347015.27 -0.70 -0.85
HLA-F -0.70 -0.80
MT-CYB -0.69 -0.83
AF347015.8 -0.68 -0.85
TSC22D4 -0.68 -0.80
S100B -0.68 -0.82

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004693 cyclin-dependent protein kinase activity TAS neuron (GO term level: 8) 1639063
GO:0000166 nucleotide binding IEA -
GO:0005515 protein binding IEA -
GO:0005524 ATP binding IEA -
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007049 cell cycle IEA -
GO:0007067 mitosis IEA -
GO:0008283 cell proliferation TAS 1639063
GO:0051301 cell division IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IDA 18029348
GO:0043231 intracellular membrane-bounded organelle IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PYEON HPV POSITIVE TUMORS UP 98 47 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269 146 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
BUSA SAM68 TARGETS DN 6 5 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174 100 All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 142 80 All SZGR 2.0 genes in this pathway