Gene Page:MPHOSPH9

Summary?
GeneID 10198
Symbol MPHOSPH9
Synonyms MPP-9|MPP9
Description M-phase phosphoprotein 9
Reference MIM:605501|HGNC:HGNC:7215|Ensembl:ENSG00000051825|HPRD:12022|Vega:OTTHUMG00000168849
Gene type protein-coding
Map location 12q24.31
Pascal p-value 3.687E-10
Fetal beta 1.081
DMG 1 (# studies)
eGene 元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
LK:YES Genome-wide Association Study This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs2851447 chr12 123665113 CG 2.189E-14 intronic MPHOSPH9

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25010444 12 123717480 MPHOSPH9 3.44E-8 -0.014 1.02E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception一周s), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C8orf12 0.68 0.38
FAM81B 0.68 0.23
CAPSL 0.67 0.29
LRRC67 0.67 0.43
C1orf88 0.66 0.31
FAM166B 0.65 0.23
C6orf91 0.65 0.23
CCDC153 0.65 0.31
WDR63 0.65 0.22
C4orf22 0.65 0.14
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ARHGEF2 -0.38 -0.51
GSK3A -0.37 -0.45
CACNB3 -0.37 -0.45
POU6F1 -0.36 -0.46
C18orf45 -0.36 -0.49
FAM160A2 -0.36 -0.48
BRSK2 -0.35 -0.48
DPH2 -0.35 -0.45
ARL4D -0.35 -0.50
MCOLN1 -0.35 -0.48

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PYEON HPV POSITIVE TUMORS UP 98 47 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165 106 All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214 134 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 TTD DN 84 63 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 108 74 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168 103 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 103 64 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING 75 44 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172 107 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM 32 15 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN 92 64 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
BUCKANOVICH T LYMPHOCYTE HOMING ON TUMOR DN 24 16 All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 74 50 All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200 115 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND HD MTX DN 25 18 All SZGR 2.0 genes in this pathway
WANG RECURRENT LIVER CANCER UP 20 13 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway