Gene Page:MPHOSPH10

Summary?
GeneID 10199
Symbol MPHOSPH10
Synonyms CT90|MPP10|MPP10P|PPP1R106
Description M-phase phosphoprotein 10
Reference MIM:605503|HGNC:HGNC:7213|Ensembl:ENSG00000124383|HPRD:10404|Vega:OTTHUMG00000129715
Gene type protein-coding
Map location 2p13.3
Pascal p-value 0.039
Sherlock p-value 0.976
Fetal beta 0.619
DMG 1 (# studies)
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg20921688 2 71357800 MPHOSPH10 7.65E-8 -0.006 1.81E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1807299 chr3 134470799 MPHOSPH10 10199 0.12 trans
rs7778042 chr7 29637891 MPHOSPH10 10199 0.19 trans
rs3779536 chr7 127233976 MPHOSPH10 10199 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconceptionweeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SAMD9L 0.60 0.74
C1S 0.55 0.68
TRIM6-TRIM34 0.54 0.60
AC068989.2 0.54 0.64
XXbac-BPG116M5.1 0.53 0.64
PTPRC 0.53 0.56
RSAD2 0.52 0.68
TLR3 0.52 0.56
C1QA 0.51 0.55
PARP9 0.51 0.66
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SOX11 -0.43 -0.42
HMGA1 -0.41 -0.49
H2AFY2 -0.40 -0.42
IGLON5 -0.40 -0.44
XKR7 -0.40 -0.45
HNRNPA0 -0.40 -0.44
ACTG1 -0.40 -0.45
LRRC3 -0.39 -0.44
TAX1BP3 -0.39 -0.45
var -0.39 -0.49

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 123 86 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 108 71 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR 74 47 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway