SZGR2 - Beplay体育中心

Summary？

GeneID	1021
象征	CDK6
Synonyms	MCPH12 \| PLSTIRE
Description	cyclin-dependent kinase 6
Reference	MIM:603368\|HGNC：HGNC：1777\|Ensembl:ENSG00000105810\|HPRD：04533\|Vega：Otthumg00000131697
基因类型	蛋白质编码
Map location	7q21-q22
Pascal p-value	0.643
胎儿β	1.445
DMG	1 (# studies)

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：JAFFE_2016	全基因组DNA甲基化分析	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	2
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关关键字的命中：2
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1642

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG26582784	7	92465342	CDK6	5.47E-11	-0.014	4.23E-7	DMG：JAFFE_2016
CG11038280	7	92466132	CDK6	5.27E-8	-0.011	1.38e-5	DMG：JAFFE_2016

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AP3M1	0.92	0.91
DHX15	0.92	0.92
hnrnpk	0.92	0.92
GMPS	0.92	0.92
MCPH1	0.92	0.92
ppm1d	0.92	0.92
COIL	0.92	0.91
cdc5l	0.92	0.92
INTS7	0.92	0.90
CRNKL1	0.92	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.70	-0.87
AF347015.31	-0.69	-0.85
mt-cyb	-0.67	-0.83
AF347015.33	-0.67	-0.82
FXYD1	-0.67	-0.83
IFI27	-0.66	-0.81
AF347015.8	-0.66	-0.84
AF347015.27	-0.66	-0.81
AIFM3	-0.65	-0.74
HLA-F	-0.65	-0.73

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0004693	cyclin-dependent protein kinase activity	IEA	神经元（GO期限：8）	-
去：0000166	nucleotide binding	IEA		-
去：0005524	ATP binding	IEA		-
GO：0016740	转移酶活性	IEA		-
去：0030332	cyclin binding	IPI		8114739
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0042063	gliogenesis	IMP	神经发生，神经胶质（GO期限：7）	12861051
去：0000080	G1 phase of mitotic cell cycle	IEP		8114739
GO:0001954	细胞矩阵粘附的阳性调节	IDA		10205165
去：0006468	protein amino acid phosphorylation	IEA		-
GO:0007049	cell cycle	IEA		-
GO:0010468	regulation of gene expression	IDA		15254224
GO:0010468	regulation of gene expression	IMP		17420273
去：0051301	cell division	IEA		-
GO:0030097	hemopoiesis	IEA		-
GO:0045646	红细胞分化的调节	IMP		12833137
GO：0048146	positive regulation of fibroblast proliferation	IMP		17420273
GO：0050680	negative regulation of epithelial cell proliferation	IMP		14985467
GO:0043697	cell dedifferentiation	IMP		12861051
GO:0045668	negative regulation of osteoblast differentiation	IDA		15254224
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0000307	细胞周期蛋白依赖性蛋白激酶全酶复合物	IDA		17420273
GO:0001726	ruffle	IDA		10205165
去：0005634	nucleus	IDA		14985467\|18029348
去：0005737	cytoplasm	IDA		14985467\|18029348

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
CCND1	bcl1 \|D11S287E \|prad1 \|U21B31	cyclin D1	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	10580009\|11360184
CCND1	bcl1 \|D11S287E \|prad1 \|U21B31	cyclin D1	-	HPRD	11739795
CCND1	bcl1 \|D11S287E \|prad1 \|U21B31	cyclin D1	CCND1 (cyclin D1) interacts with CDK6.	绑定	12867429
CCND2	Kiak0002 \|MGC102758	cyclin D2	-	HPRD,BioGRID	11358847
CCND3	-	cyclin D3	-	HPRD,BioGRID	8114739\|11360184
CDK2	p33(CDK2)	cyclin-dependent kinase 2	共纯化	Biogrid	10934208
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	-	HPRD	11124804
CDK7	cak1 \|CDKN7 \|mo15 \|STK1 \|P39MO15	cyclin-dependent kinase 7	CAK磷酸化CDK6。这种相互作用是基于未指定物种的人CAK和CDK6之间的相互作用进行建模的。	绑定	7629134
CDKN1B	CDKN4 \|Kip1 \|men1b \|Men4 \|P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	亲和力捕获 - 韦斯特恩	Biogrid	11360184
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	CDKN2Ainteracts with CDK6	绑定	11556834
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	p16 interacts with CDK6. This interaction was modeled on a demonstrated interaction between human p16 and CDK6 from an unspecified species.	绑定	10491434
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	p16 interacts with cdk6. This interaction was modeled on a demonstrated interaction between human p16 and cdk6 from an unspecified species.	绑定	9482104
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	p16 interacts with cdk6.	绑定	8805225
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	-	HPRD,BioGRID	9751050
CDKN2C	INK4C \| p18 \| p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	-	HPRD,BioGRID	8001816
CDKN2C	INK4C \| p18 \| p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	An unspecified isoform of p18 interacts with cdk6. This interaction was modeled on a demonstrated interaction between human p18 and cdk6 from an unspecified species.	绑定	9482104
CDKN2D	INK4D \| p19 \| p19-INK4D	细胞周期蛋白依赖性激酶抑制剂2D（P19，抑制CDK4）	-	HPRD,BioGRID	9751050 \| 9751051
CNOT7	CAF1 \|HCAF-1	CCR4-NOT transcription complex, subunit 7	-	HPRD	10602502
MCM10	CNA43 \|DNA43 \|MGC126776 \|Pro2249	minichromosome maintenance complex component 10	-	HPRD	15232106
PCNA	MGC8367	增殖细胞核抗原	-	HPRD	9667749
ppm1b	MGC21657 \|pp2c-beta-x \|pp2cb \|pp2cbeta \|ppc2betax	蛋白质磷酸酶1B（以前为2C），镁依赖性β同工型	-	HPRD,BioGRID	10934208
PPP2CA	pp2ac \|pp2ca \|RP-C	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	生化活动共纯化	Biogrid	10934208
RB1	OSRC \|RB \|P105-RB \|PRB \|PP110	retinoblastoma 1	CDK6phosphorylates Rb. This interaction was modeled on a demonstrated interaction between CDK6 and Rb, both from an unspecified species.	绑定	7629134
RB1	OSRC \|RB \|P105-RB \|PRB \|PP110	retinoblastoma 1	CDK6磷酸化RB	绑定	10339564

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg细胞周期	128	84	All SZGR 2.0 genes in this pathway
KEGG P53信号通路	69	45	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
Kegg神经胶质瘤	65	56	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG慢性髓细胞性白血病	73	59	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
生物卡塔尔细胞途径	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID AR途径	61	46	All SZGR 2.0 genes in this pathway
PID CMYB途径	84	61	All SZGR 2.0 genes in this pathway
PID IL2 STAT5 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
反应组细胞周期	421	253	All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC	325	185	All SZGR 2.0 genes in this pathway
Reactome G1相	38	23	All SZGR 2.0 genes in this pathway
Reactome有丝分裂G1 G1 S相	137	79	All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应	391	222	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN	460	312	All SZGR 2.0 genes in this pathway
vecchi胃癌早期	430	232	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP	55	34	All SZGR 2.0 genes in this pathway
Senese HDAC1靶向	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
Jaatinen造血干细胞向上	316	190	All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性	722	443	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN	77	52	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP	29	20	All SZGR 2.0 genes in this pathway
斯尼德斯在头部和颈部肿瘤中放大	37	27	All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE	217	143	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向神经上皮	176	111	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS	148	97	All SZGR 2.0 genes in this pathway
HE PTEN TARGETS UP	16	15	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP	53	37	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 7Q21 Q22 AMPLICON	76	33	All SZGR 2.0 genes in this pathway
TCGA胶质母细胞瘤副本编号	75	36	All SZGR 2.0 genes in this pathway
YAGI AML RELAPSE PROGNOSIS	35	24	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN	51	32	All SZGR 2.0 genes in this pathway
Yagi AML生存	129	87	All SZGR 2.0 genes in this pathway
伊万诺娃造血早期祖先	532	309	All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6	52	32	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应	953	554	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应	1011	592	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
伽玛辐射8G后的生存率不佳	95	62	All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性	578	341	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D DN	64	35	All SZGR 2.0 genes in this pathway
怀特福德小儿癌标记	116	63	All SZGR 2.0 genes in this pathway
布鲁克纳MIRLET7A3的目标	111	69	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
格雷希克癌症复制号码	323	240	All SZGR 2.0 genes in this pathway
Lee胸前T祖细胞	21	14	All SZGR 2.0 genes in this pathway
MIKKELSEN PLURIPOTENT STATE DN	8	7	All SZGR 2.0 genes in this pathway
Shaffer IRF4多发性骨髓瘤计划	36	25	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP	176	110	All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN	41	25	All SZGR 2.0 genes in this pathway
ono foxp3目标dn	42	23	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP	80	54	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S2	115	74	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL	162	122	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR DN	91	56	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BHAT ESR1不是通过AKT1 DN的目标	88	61	All SZGR 2.0 genes in this pathway
BHAT ESR1通过AKT1 DN目标	82	51	All SZGR 2.0 genes in this pathway
Johnstone Parvb目标2 DN	336	211	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
Linsley mir16目标	206	127	All SZGR 2.0 genes in this pathway
pasini suz12靶向DN	315	215	All SZGR 2.0 genes in this pathway
BMI1和PCGF2的Wiederschain目标	57	39	All SZGR 2.0 genes in this pathway
GOBERT核心OLIGODENDROCYTE DIFFERENTIATION	40	28	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE	114	62	All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP	289	184	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-1/206	8950	8957	1A，M8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	Uggaauguaaggaagugugugg
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
mir-101	7946	7952	M8	hsa-miR-101	uacaguacugauaacugaag
miR-103/107	309	315	M8	hsa-miR-103^brain	agcagcauuguacggcuauga
miR-103/107	309	315	M8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
mir-124.1	1648	1654	M8	HSA-MIR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1648	1654	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1648	1654	1A	HSA-MIR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-137	7133	7139	1A	HSA-MIR-137	uauugcuuaagaauacgcguag
miR-141/200a	470	476	1A	HSA-MIR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	470	476	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-145	9863	9869	M8	HSA-MIR-145	guccaguuucccaggaaucccuu
mir-214	267	273	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
mir-25/32/92/363/367	7113	7119	1A	hsa-miR-25^brain	Cauugcacuugucucggucuga
				hsa-miR-32	uauugcacauacuaaguugc
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				HSA-MIR-367	Aauugcacuuuagcaaugga
				hsa-miR-92b^SZ	uauugcacucgucccgcgcuc
miR-26	7079	7086	1A，M8	HSA-MIR-26A^brain	UUCAAGUAAUCCAGGAUAGGC
				HSA-MIR-26B^SZ	UUCAAGUAAUUCAGGAUAGGUU
				HSA-MIR-26A^brain	UUCAAGUAAUCCAGGAUAGGC
				HSA-MIR-26B^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-29	9880	9886	1A	HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	UAGCACCAUUUGAAAUCGGU
				HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	UAGCACCAUUUGAAAUCGGU
mir-320	193	200	1A，M8	hsa-miR-320	aaaagcugggugagaggggcgaa
miR-33	7111	7117	1A	hsa-miR-33	Gugcauuguuguugcauug
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
				hsa-miR-33	Gugcauuguuguugcauug
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
mir-330	9132	9139	1A，M8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-34/449	9172	9178	M8	hsa-miR-34a^brain	uggcaguguuaguguguuuu
				hsa-miR-34c	Aggcaguguaguagcugauugc
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				HSA-MIR-449B	AGGCAGUGUAUUGUUAGCUGGC
miR-34b	9173	9179	M8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-494	229	235	1A	HSA-MIR-494^brain	ugaaacauacgggaaaccucuu
miR-495	210	216	M8	HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
miR-495	210	216	M8	HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:CDK6