Gene Page:PSMD14
Summary?
| GeneID | 10213 |
| Symbol | PSMD14 |
| Synonyms | PAD1|POH1|RPN11 |
| Description | 26 s蛋白酶体亚基,non-ATPase 14所示 |
| Reference | MIM:607173|HGNC:HGNC:16889|Ensembl:ENSG00000115233|HPRD:06208|Vega:OTTHUMG00000153882 |
| Gene type | protein-coding |
| Map location | 2q24.2 |
| Pascal p-value | 0.354 |
| Sherlock p-value | 0.578 |
| Fetal beta | 0.12 |
| eGene | Myers' cis & trans Meta |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.humanPSD G2Cdb.humanPSP |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.02395 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4491879 | chr3 | 189373908 | PSMD14 | 10213 | 0.18 | trans | ||
| rs4505678 | chr3 | 189374356 | PSMD14 | 10213 | 0.2 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DCTN3 | 0.87 | 0.88 |
| POP7 | 0.85 | 0.86 |
| ARL16 | 0.85 | 0.88 |
| C16orf91 | 0.85 | 0.84 |
| AC174470.1 | 0.83 | 0.85 |
| ARF5 | 0.82 | 0.83 |
| ASNA1 | 0.82 | 0.84 |
| NT5C3L | 0.82 | 0.85 |
| AIP | 0.82 | 0.82 |
| MRPL14 | 0.82 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.26 | -0.64 | -0.70 |
| AF347015.15 | -0.60 | -0.65 |
| MYH14 | -0.60 | -0.62 |
| AF347015.33 | -0.59 | -0.64 |
| AF347015.8 | -0.59 | -0.63 |
| MT-CYB | -0.58 | -0.64 |
| AF347015.2 | -0.58 | -0.62 |
| AF347015.27 | -0.57 | -0.64 |
| ZBTB7B | -0.56 | -0.59 |
| KIF1C | -0.55 | -0.58 |
Section III. Gene Ontology annotation
| Molecular function | 去term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去:0005515 | protein binding | 新闻学会 | 17353931 | |
| Biological process | 去term | Evidence | Neuro keywords | PubMed ID |
| 去:0006511 | ubiquitin-dependent protein catabolic process | TAS | 9374539 | |
| 去:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | EXP | 11285280 | |
| 去:0051436 | negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle | EXP | 15029244 | |
| 去:0051437 | positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle | EXP | 12791267 | |
| Cellular component | 去term | Evidence | Neuro keywords | PubMed ID |
| 去:0000502 | proteasome complex | TAS | 9374539 | |
| 去:0005829 | cytosol | 国际能源机构 | - | |
| 去:0005634 | nucleus | IDA | 18029348 | |
| 去:0005730 | nucleolus | IDA | 18029348 | |
| 去:0005737 | cytoplasm | IDA | 18029348 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PROTEASOME | 48 | 28 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PROTEASOME PATHWAY | 28 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY WNT | 65 | 41 | All SZGR 2.0 genes in this pathway |
| REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 48 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | 76 | 48 | All SZGR 2.0 genes in this pathway |
| REACTOME ER PHAGOSOME PATHWAY | 61 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 67 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 97 | 66 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
| REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | 51 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | 48 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 200 | 136 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 49 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF APOPTOSIS | 58 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME细胞周期有丝分裂 | 325 | 185 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE CHECKPOINTS | 124 | 70 | All SZGR 2.0 genes in this pathway |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 65 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | 57 | 35 | All SZGR 2.0 genes in this pathway |
| REACTOME M G1 TRANSITION | 81 | 45 | All SZGR 2.0 genes in this pathway |
| REACTOME G1 S TRANSITION | 112 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 56 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF DNA | 92 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 51 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME MITOTIC G1 G1 S PHASES | 137 | 79 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 85 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME MITOTIC M M G1 PHASES | 172 | 98 | All SZGR 2.0 genes in this pathway |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 65 | 36 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | 53 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME DNA REPLICATION | 192 | 110 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOSIS | 148 | 94 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 132 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 72 | 38 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 73 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 64 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 51 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 251 | 156 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 212 | 129 | All SZGR 2.0 genes in this pathway |
| REACTOME S PHASE | 109 | 66 | All SZGR 2.0 genes in this pathway |
| REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | 56 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 52 | 30 | All SZGR 2.0 genes in this pathway |
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP | 285 | 181 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | All SZGR 2.0 genes in this pathway |
| NADERI BREAST CANCER PROGNOSIS UP | 50 | 26 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER MYC TARGETS REPRESSED BY SERUM | 159 | 93 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER UP | 358 | 245 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| BASSO B LYMPHOCYTE NETWORK | 143 | 96 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS | 185 | 114 | All SZGR 2.0 genes in this pathway |
| PENG LEUCINE DEPRIVATION DN | 187 | 122 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST DN | 309 | 206 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE DN | 245 | 154 | All SZGR 2.0 genes in this pathway |
| FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP | 63 | 48 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA SUBGROUPS | 30 | 20 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| SESTO RESPONSE TO UV C2 | 54 | 39 | All SZGR 2.0 genes in this pathway |
| RHODES UNDIFFERENTIATED CANCER | 69 | 44 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | All SZGR 2.0 genes in this pathway |
| JIANG AGING HYPOTHALAMUS UP | 47 | 31 | All SZGR 2.0 genes in this pathway |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN | 49 | 38 | All SZGR 2.0 genes in this pathway |
| WONG PROTEASOME GENE MODULE | 49 | 35 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| CHUNG BLISTER CYTOTOXICITY UP | 134 | 84 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER UP | 285 | 167 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR UP | 294 | 199 | All SZGR 2.0 genes in this pathway |
| CHANG CORE SERUM RESPONSE UP | 212 | 128 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G3 UP | 188 | 121 | All SZGR 2.0 genes in this pathway |
| KYNG WERNER SYNDROM AND NORMAL AGING DN | 225 | 124 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| WONG EMBRYONIC STEM CELL CORE | 335 | 193 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | 181 | 101 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |