Gene Page:CDK7

Summary?
GeneID 1022
Symbol CDK7
Synonyms CAK1|CDKN7|HCAK|MO15|STK1|p39MO15
Description cyclin-dependent kinase 7
Reference MIM:601955|HGNC:HGNC:1778|Ensembl:ENSG00000134058|HPRD:15993|织女:OTTHUMG00000099358
Gene type protein-coding
Map location 5q12.1
Pascal p-value 0.844
Sherlock p-value 0.011
Fetal beta 0.48

Gene in Data Sources
Gene set name Method of gene set Description Info
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BOK 0.80 0.82
SLC26A11 0.75 0.70
VAT1 0.74 0.67
RGS19 0.73 0.58
EPS8L1 0.71 0.41
RAC3 0.71 0.52
MVK 0.71 0.73
PIP5KL1 0.69 0.51
NAGLU 0.69 0.70
RNF220 0.68 0.57
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.45 -0.57
MT-CO2 -0.44 -0.57
AF347015.8 -0.42 -0.56
AF347015.21 -0.42 -0.60
MT-CYB -0.41 -0.55
CXCL14 -0.41 -0.53
AF347015.27 -0.41 -0.53
CARD16 -0.40 -0.58
AF347015.33 -0.40 -0.51
EAF2 -0.40 -0.51

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004693 cyclin-dependent protein kinase activity TAS neuron (GO term level: 8) 8208544
GO:0000166 nucleotide binding IEA -
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005524 ATP binding IEA -
GO:0016740 transferase activity IEA -
GO:0008353 RNA polymerase subunit kinase activity IEA -
GO:0008022 protein C-terminus binding 新闻学会 10801852
GO:0050681 androgen receptor binding NAS 15572661
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000079 c的监管yclin-dependent protein kinase activity TAS 7533895
GO:0000718 nucleotide-excision repair, DNA damage removal EXP 10583946
GO:0006367 transcription initiation from RNA polymerase II promoter EXP 8946909
GO:0006367 transcription initiation from RNA polymerase II promoter TAS 7533895
GO:0006368 RNA elongation from RNA polymerase II promoter EXP 9405375
GO:0006350 transcription IEA -
GO:0006468 protein amino acid phosphorylation IEA -
去:0006281 DNA repair IEA -
GO:0007049 cell cycle IEA -
GO:0008283 cell proliferation TAS 7533895
GO:0051301 cell division IEA -
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 8692841
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm EXP 1939271|2449431|7629134
|7799941|8946909
|9512541|9582279
|9790902|10214908
|11313499|12393749
|12646563

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AR AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM androgen receptor Affinity Capture-Western
Reconstituted Complex		 BioGRID 10734072
CCNH CAK | p34 | p37 cyclin H Affinity Capture-MS
Affinity Capture-Western
Two-hybrid		 BioGRID 8078587
CCNH CAK | p34 | p37 cyclin H - HPRD 9056480
CDK2 p33(CDK2) cyclin-dependent kinase 2 CDK7 phosphorylates an unspecified isoform of CDK2. BIND 7629134
CDK6 MGC59692 | PLSTIRE | STQTL11 cyclin-dependent kinase 6 CAK phosphorylates CDK6. This interaction was modeled on a demonstrated interaction between human CAK and CDK6 from an unspecified species. BIND 7629134
CUX1 CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75 cut-like homeobox 1 Reconstituted Complex BioGRID 11584018
E2F1 E2F-1 | RBAP1 | RBBP3 | RBP3 E2F transcription factor 1 Affinity Capture-Western BioGRID 10428966
ERCC2 COFS2 | EM9 | MGC102762 | MGC126218 | MGC126219 | TTD | XPD 切除再保险pair cross-complementing rodent repair deficiency, complementation group 2 - HPRD 11445587
ERCC3 BTF2 | GTF2H | RAD25 | TFIIH | XPB 切除再保险pair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) - HPRD,BioGRID 9130708
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 estrogen receptor 1 Biochemical Activity BioGRID 10949034
GTF2H1 BTF2 | TFB1 | TFIIH general transcription factor IIH, polypeptide 1, 62kDa - HPRD,BioGRID 9130708
GTF2H2 BTF2 | BTF2P44 | MGC102806 | T-BTF2P44 | TFIIH general transcription factor IIH, polypeptide 2, 44kDa - HPRD 9130708
GTF2H5 C6orf175 | TFB5 | TGF2H5 | TTD | TTD-A | TTDA | bA120J8.2 general transcription factor IIH, polypeptide 5 - HPRD,BioGRID 11062469|15220921
HDAC2 RPD3 | YAF1 histone deacetylase 2 Affinity Capture-Western BioGRID 12527756
HNRNPU HNRPU | SAF-A | U21.1 heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) Affinity Capture-Western BioGRID 10490622
MCM7 CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146 minichromosome maintenance complex component 7 - HPRD,BioGRID 11056214
MED21 SRB7 | SURB7 mediator complex subunit 21 Affinity Capture-Western BioGRID 9315662
MNAT1 MAT1 | RNF66 | TFB3 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) - HPRD,BioGRID 8521393
MNAT1 MAT1 | RNF66 | TFB3 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) - HPRD 9130708
MTA1 - metastasis associated 1 Affinity Capture-Western BioGRID 12527756
RARA NR1B1 | RAR retinoic acid receptor, alpha RAR-alpha interacts with hMo15. BIND 15249124
TCEA1 GTF2S | SII | TCEA | TF2S | TFIIS transcription elongation factor A (SII), 1 Reconstituted Complex BioGRID 9305922
THRA AR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1 thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) TR-alpha interacts with hMo15. This interaction was modeled on a demonstrated interaction between chicken TR-alpha and human hMo15. BIND 15249124
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 Affinity Capture-Western
Biochemical Activity		 BioGRID 9372954|9840937
VDR NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor VDR interacts with hMo15. BIND 15249124


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NUCLEOTIDE EXCISION REPAIR 44 25 All SZGR 2.0 genes in this pathway
KEGG CELL CYCLE 128 84 All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY 23 15 All SZGR 2.0 genes in this pathway
BIOCARTA PTC1 PATHWAY 11 6 All SZGR 2.0 genes in this pathway
SA G2 AND M PHASES 8 7 All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 30 23 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION TERMINATION 22 12 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 89 64 All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION 105 54 All SZGR 2.0 genes in this pathway
REACTOME MRNA CAPPING 30 11 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 65 40 All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE 38 23 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION COUPLED NER TC NER 45 24 All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 41 21 All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING 161 86 All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210 127 All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR 51 27 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 45 19 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 15 8 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX 30 13 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 122 80 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 81 50 All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 112 59 All SZGR 2.0 genes in this pathway
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 61 32 All SZGR 2.0 genes in this pathway
REACTOME GLOBAL GENOMIC NER GG NER 35 20 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 23 11 All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207 122 All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 125 69 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX 34 11 All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 104 61 All SZGR 2.0 genes in this pathway
REACTOME S PHASE 109 66 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION INITIATION 25 14 All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES DN 145 91 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 98 58 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 101 66 All SZGR 2.0 genes in this pathway
SILIGAN TARGETS OF EWS FLI1 FUSION UP 15 12 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 81 51 All SZGR 2.0 genes in this pathway
考夫曼DNA修复基因 230 137 All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS UP 35 25 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP 63 48 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 89 61 All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES 45 34 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 69 41 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 98 67 All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D6 37 25 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 107 72 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223 132 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 148 95 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-496 114 121 1A,m8 hsa-miR-496 AUUACAUGGCCAAUCUC
hsa-miR-496 AUUACAUGGCCAAUCUC