Gene Page:COQ7

Summary?
GeneID 10229
Symbol COQ7
Synonyms CAT5|CLK-1|CLK1|COQ10D8
Description coenzyme Q7 homolog, ubiquinone (yeast)
Reference MIM:601683|HGNC:HGNC:2244|Ensembl:ENSG00000167186|HPRD:03401|Vega:OTTHUMG00000131455
Gene type protein-coding
Map location 16p12.3
Pascal p-value 0.385
Fetal beta 0.005
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01775

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg27054524 16 19097807 COQ7 3.89E-8 -0.007 1.11E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FIBP 0.80 0.79
UCHL1 0.80 0.75
AC011479.2 0.80 0.76
C19orf62 0.79 0.80
ARPC4 0.79 0.77
RRAGA 0.79 0.74
PMM1 0.79 0.81
MANBAL 0.79 0.80
STOML1 0.79 0.78
TSFM 0.78 0.77
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.18 -0.59 -0.47
AF347015.26 -0.58 -0.43
AF347015.8 -0.55 -0.38
AF347015.2 -0.55 -0.38
AF347015.33 -0.53 -0.39
AF347015.15 -0.52 -0.37
MT-CO2 -0.52 -0.35
MT-ATP8 -0.52 -0.38
MT-CYB -0.51 -0.37
C10orf108 -0.50 -0.50

Section III. Gene Ontology annotation

Molecular function 去你rm Evidence Neuro keywords PubMed ID
GO:0005506 iron ion binding IEA -
GO:0016491 oxidoreductase activity IEA -
Biological process 去你rm Evidence Neuro keywords PubMed ID
GO:0006744 ubiquinone biosynthetic process TAS 10501970
GO:0019538 protein metabolic process IEA -
Cellular component 去你rm Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 11256614
GO:0005739 mitochondrion TAS 10501970

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BERENJENO通过RHOA转换 536 340 All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 LASER UP 34 25 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 89 59 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181 101 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway