Gene Page:MSLN

Summary?
GeneID 10232
Symbol MSLN
Synonyms MPF|SMRP
Description mesothelin
Reference MIM:601051|HGNC:HGNC:7371|Ensembl:ENSG00000102854|HPRD:03030|Vega:OTTHUMG00000047992
Gene type protein-coding
Map location 16p13.3
Pascal p-value 0.066
Fetal beta -0.188
DMG 1 (# studies)
eGene Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08700707 16 809679 MSLN 2.037E-4 -0.493 0.035 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
相约: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TAP1 0.93 0.87
IFIT3 0.93 0.87
IFITM3 0.92 0.75
MX1 0.90 0.89
IFIT1 0.90 0.80
IFI35 0.88 0.81
TAPBPL 0.87 0.83
MT1E 0.87 0.81
PLSCR1 0.86 0.72
OAS1 0.86 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RTF1 -0.54 -0.63
PHF14 -0.53 -0.71
DHX57 -0.52 -0.69
POLR2B -0.52 -0.71
PJA1 -0.52 -0.66
HEATR5B -0.52 -0.63
PCDHB10 -0.51 -0.66
SAFB -0.51 -0.64
PRPF6 -0.51 -0.68
THOC2 -0.51 -0.65

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 DN 48 28 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232 139 All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS DN 133 77 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP 141 75 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 All SZGR 2.0 genes in this pathway
BERENJENO通过RHOA转换 536 340 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS UP 51 27 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER 111 69 All SZGR 2.0 genes in this pathway
WOTTON RUNX TARGETS DN 29 18 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER E 89 44 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16P13 AMPLICON 120 49 All SZGR 2.0 genes in this pathway
LEI HOXC8 TARGETS UP 12 12 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 71 48 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE 77 50 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 132 93 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 9 35 26 All SZGR 2.0 genes in this pathway
VALK AML WITH 11Q23 REARRANGED 22 13 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 130 87 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3 162 80 All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO DOXORUBICIN 17 10 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 DN 39 21 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
DELACROIX RAR TARGETS UP 48 33 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway