Gene Page:CALCOCO2

Summary?
GeneID 10241
Symbol CALCOCO2
Synonyms NDP52
Description calcium binding and coiled-coil domain 2
Reference MIM:604587|HGNC:HGNC:29912|Ensembl:ENSG00000136436|HPRD:06846|Vega:OTTHUMG00000160505
Gene type protein-coding
Map location 17q21.32
Pascal p-value 8.427E-4
Sherlock p-value 0.472
eGene Cerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AMY2B 0.69 0.66
UGCGL2 0.62 0.57
TTC14 0.62 0.52
CATSPER2 0.61 0.56
AHSA2 0.60 0.49
OVGP1 0.60 0.52
AC015813.1 0.59 0.58
ZNF404 0.59 0.52
AP000769.2 0.58 0.54
AMY2A 0.58 0.48
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SHISA5 -0.40 -0.49
TUFM -0.40 -0.45
ACTG1 -0.40 -0.40
ACTB -0.40 -0.42
AC025287.3 -0.39 -0.42
FSCN1 -0.39 -0.40
SFRS2B -0.39 -0.38
SNX12 -0.39 -0.40
AC008629.2 -0.38 -0.46
HMGA1 -0.38 -0.38

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ABLIM1 ABLIM | DKFZp781D0148| FLJ14564 | KIAA0059 | LIMAB1 | LIMATIN | MGC1224 actin binding LIM protein 1 Two-hybrid BioGRID 16189514
APEX2 APE2 | APEXL2 | XTH2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 Two-hybrid BioGRID 16189514
C16orf48 DAKV6410 | DKFZp434A1319 chromosome 16 open reading frame 48 Two-hybrid BioGRID 16189514
C1orf65 FLJ35728 | RP11-76K24.1 chromosome 1 open reading frame 65 Two-hybrid BioGRID 16189514
C20orf195 MGC5356 chromosome 20 open reading frame 195 Two-hybrid BioGRID 16189514
C9orf86 FLJ10101 | FLJ13045 | Parf | RBEL1 | bA216L13.9 | pp8875 chromosome 9 open reading frame 86 Two-hybrid BioGRID 16189514
CALCOCO2 MGC17318 | NDP52 calcium binding and coiled-coil domain 2 Two-hybrid BioGRID 16189514
CCDC33 FLJ23168 | FLJ32855 | MGC34145 coiled-coil domain containing 33 Two-hybrid BioGRID 16189514
CPNE7 MGC34192 copine VII Two-hybrid BioGRID 16189514
DAZAP2 KIAA0058 | MGC14319 | MGC766 | PRTB DAZ associated protein 2 Two-hybrid BioGRID 16189514
DBNDD2 C20orf35 | CK1BP | HSMNP1 dysbindin (dystrobrevin binding protein 1) domain containing 2 Two-hybrid BioGRID 16189514
DKFZp761E198 PP1030 DKFZp761E198 protein Two-hybrid BioGRID 16189514
FAM107A DRR1 | FLJ30158 | FLJ45473 | TU3A family with sequence similarity 107, member A Two-hybrid BioGRID 16189514
FAM164C C14orf140 | FLJ23093 family with sequence similarity 164, member C Two-hybrid BioGRID 16189514
FASTK FAST Fas-activated serine/threonine kinase Two-hybrid BioGRID 16189514
FBF1 Alb | FBF-1 | FLJ00103 Fas (TNFRSF6) binding factor 1 Two-hybrid BioGRID 16189514
FBXL18 FLJ10776 | FLJ11467 | FLJ26934 | FLJ38075 | FLJ41541 | Fbl18 F-box and leucine-rich repeat protein 18 Two-hybrid BioGRID 16189514
FXR2 FMR1L2 fragile X mental retardation, autosomal homolog 2 Two-hybrid BioGRID 16189514
GABARAPL1 APG8-LIKE | APG8L | ATG8 | ATG8L | GEC1 GABA(A) receptor-associated protein like 1 Two-hybrid BioGRID 16189514
GABARAPL2 ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2 GABA(A) receptor-associated protein-like 2 Two-hybrid BioGRID 16189514
GEMIN4 DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97 gem (nuclear organelle) associated protein 4 HCAP1 interacts with NDP52 BIND 12869526
KIAA1267 DKFZp686P06109 | DKFZp727C091 | MGC102843 KIAA1267 Two-hybrid BioGRID 16189514
LGALS8 Gal-8 | PCTA-1 | PCTA1 | Po66-CBP lectin, galactoside-binding, soluble, 8 Two-hybrid BioGRID 16189514
LNX1 LNX | MPDZ | PDZRN2 ligand of numb-protein X 1 Two-hybrid BioGRID 16189514
LSM4 YER112W LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) Two-hybrid BioGRID 16189514
MCM10 CNA43 | DNA43 | MGC126776 | PRO2249 minichromosome maintenance complex component 10 Two-hybrid BioGRID 16189514
MYST2 HBO1 | HBOA | KAT7 MYST histone acetyltransferase 2 Two-hybrid BioGRID 16189514
PCGF1 2010002K04Rik | FLJ43754 | MGC10882 | NSPC1 | RNF3A-2 | RNF68 polycomb group ring finger 1 Two-hybrid BioGRID 16189514
PIAS4 FLJ12419 | MGC35296 | PIASY | Piasg | ZMIZ6 protein inhibitor of activated STAT, 4 Two-hybrid BioGRID 16189514
POLI RAD30B | RAD3OB polymerase (DNA directed) iota Two-hybrid BioGRID 16189514
PSMA1 HC2 | MGC14542 | MGC14575 | MGC14751 | MGC1667 | MGC21459 | MGC22853 | MGC23915 | NU | PROS30 proteasome (prosome, macropain) subunit, alpha type, 1 Two-hybrid BioGRID 16189514
PTBP1 HNRNP-I | HNRNPI | HNRPI | MGC10830 | MGC8461 | PTB | PTB-1 | PTB-T | PTB2 | PTB3 | PTB4 | pPTB polypyrimidine tract binding protein 1 Two-hybrid BioGRID 16189514
PTBP2 FLJ34897 | PTB | PTBLP | brPTB | nPTB | nPTB5 | nPTB6 | nPTB7 | nPTB8 polypyrimidine tract binding protein 2 Two-hybrid BioGRID 16189514
RHPN1 KIAA1929 | ODF5 | RHOPHILIN | RHPN rhophilin, Rho GTPase binding protein 1 Two-hybrid BioGRID 16189514
SHC1 FLJ26504 | SHC | SHCA SHC (Src homology 2 domain containing) transforming protein 1 Two-hybrid BioGRID 16189514
SMARCD1 BAF60A | CRACD1 | Rsc6p SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Two-hybrid BioGRID 16189514
SRI FLJ26259 | SCN sorcin Two-hybrid BioGRID 16189514
TCEB3B ELOA2 | HsT832 | MGC119351 | TCEB3L transcription elongation factor B polypeptide 3B (elongin A2) Two-hybrid BioGRID 16189514
TCL1A TCL1 T-cell leukemia/lymphoma 1A Two-hybrid BioGRID 16189514
TP53RK BUD32 | C20orf64 | Nori-2 | Nori-2p | PRPK | dJ101A2 TP53 regulating kinase Two-hybrid BioGRID 16189514
TRAF2 MGC:45012 | TRAP | TRAP3 TNF receptor-associated factor 2 Two-hybrid BioGRID 16189514
VPS72 CFL1 | Swc2 | TCFL1 | YL-1 | YL1 vacuolar protein sorting 72 homolog (S. cerevisiae) Two-hybrid BioGRID 16189514
ZNF101 DKFZp570I0164 | HZF12 | MGC149565 | MGC149566 zinc finger protein 101 Two-hybrid BioGRID 16189514
ZNF205 ZNF210 | Zfp13 锌指蛋白205 Two-hybrid BioGRID 16189514
ZNF408 FLJ12827 zinc finger protein 408 Two-hybrid BioGRID 16189514
ZNF426 MGC2663 zinc finger protein 426 Two-hybrid BioGRID 16189514
ZNF451 COASTER | FLJ23421 | FLJ53246 | FLJ90693 | KIAA0576 | KIAA1702 | MGC26701 | dJ417I1.1 zinc finger protein 451 Two-hybrid BioGRID 16189514
ZNF638 DKFZp686P1231 | MGC26130 |MGC90196 | NP220 | ZFML | Zfp638 zinc finger protein 638 Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN 47 33 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 49 29 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181 106 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 112 65 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266 142 All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275 155 All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 107 72 All SZGR 2.0 genes in this pathway