Gene Page:CDKN1B

Summary？
GeneID 1027
Symbol CDKN1B
Synonyms CDKN4|KIP1|MEN1B|MEN4|P27KIP1
Description cyclin-dependent kinase inhibitor 1B
Reference MIM：600778|HGNC：HGNC：1785|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914
基因类型 蛋白质编码
Map location 12p13.1-p12
Pascal p-value 0.249
Sherlock p-value 8.849e-6
胎儿β 0.697

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
Network Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：0.0925

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAD2L1 0.90 0.72
CCNB1 0.90 0.72
CENPN 0.89 0.74
CKS2 0.87 0.59
CHEK2 0.87 0.65
PBK 0.86 0.32
KIAA0101 0.86 0.31
HMGB2 0.86 0.55
RAD51AP1 0.86 0.46
AURKA 0.86 0.52
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.26 -0.34 -0.28
AF347015.15 -0.33 -0.26
AF347015.8 -0.33 -0.25
mt-cyb -0.33 -0.26
apol1 -0.32 -0.27
AF347015.2 -0.32 -0.24
AF347015.33 -0.31 -0.24
MT-CO2 -0.31 -0.22
SLC9A3R2 -0.31 -0.23
AF347015.18 -0.31 -0.31

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity TAS 8033212
去：0005515 蛋白质结合 IPI 8756624|9106657|9840943
|12082530|15057270
|15652749|15890360
|17254966|17254967
去:0004861 细胞周期蛋白依赖性蛋白激酶抑制剂活性 TAS 10918569
去:0004860 protein kinase inhibitor activity IEA -
Biological process 去学期 证据 神经关键字 PubMed ID
去：0000079 regulation of cyclin-dependent protein kinase activity TAS 8033212
去：0000082 G1/s有丝分裂细胞周期的过渡 IDA 10208428
去:0006917 诱导凋亡 IDA 10208428
去:0007049 cell cycle IEA -
去:0007050 cell cycle arrest IMP 12093740
去:0008285 negative regulation of cell proliferation TAS 8033212
GO：0048102 自噬细胞死亡 IDA 12698196
GO：0042326 negative regulation of phosphorylation IDA 10208428
去：0030308 negative regulation of cell growth IDA 10208428
Cellular component 去学期 证据 神经关键字 PubMed ID
去:0005829 细胞质 EXP 12244303
去：0005634 nucleus IDA 12093740
去：0005737 cytoplasm IDA 12093740

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
AKT1 一种蛋白激酶| MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 亲和力捕获 - 韦斯特恩
生化活动		 Biogrid 12042314
ARHGDIA GDIA1 | MGC117248 | RHOGDI | RHOGDI-1 Rho GDP dissociation inhibitor (GDI) alpha Two-hybrid Biogrid 16169070
CCNA1 - cyclin A1 cyclin A1 interacts with p27. 绑定 10022926
CCNA2 CCN1 | CCNA cyclin A2 P27与CYC A相互作用。 绑定 15469821
CCNA2 CCN1 | CCNA cyclin A2 p27 interacts with cyclin A. 绑定 9632134
CCNA2 CCN1 | CCNA cyclin A2 - HPRD,BioGRID 12501191
CCNA2 CCN1 | CCNA cyclin A2 p27 interacts with cyclin A. 绑定 15652749
CCND1 bcl1 |D11S287E |prad1 |U21B31 cyclin D1 体外
重构的复合物		 Biogrid 10908655|11360184
CCND1 bcl1 |D11S287E |prad1 |U21B31 cyclin D1 p27 interacts with cyclin D. 绑定 9632134
CCND1 bcl1 |D11S287E |prad1 |U21B31 cyclin D1 - HPRD 7478582|10908655
CCND2 Kiak0002 |MGC102758 cyclin D2 Two-hybrid Biogrid 16189514
CCND3 - cyclin D3 亲和力捕获 - 韦斯特恩
重构的复合物
Two-hybrid		 Biogrid 10342870|11360184
|16189514
CCNE1 CCNE cyclin E1 p27 interacts with cyclin E. 绑定 9632134
CCNE1 CCNE cyclin E1 p27 interacts with Cyc E. 绑定 15469821
CCNE1 CCNE cyclin E1 亲和力捕获 - 韦斯特恩 Biogrid 9891079|12529437
CCNE2 cyce2 cyclin E2 - HPRD 9858585
CDK2 p33(CDK2) cyclin-dependent kinase 2 p27 interacts with an unspecified isoform of CDK2. 绑定 15652749
CDK2 p33(CDK2) cyclin-dependent kinase 2 CDK2与P27KIP1相互作用。 绑定 15619620
CDK2 p33(CDK2) cyclin-dependent kinase 2 - HPRD,BioGRID 12972555
CDK2 p33(CDK2) cyclin-dependent kinase 2 CDK2与P27相互作用。 绑定 15469821
CDK4 CMM3 |MGC14458 |PSK-J3 cyclin-dependent kinase 4 - HPRD,BioGRID 10908655
CDK6 MGC59692 | PLSTIRE | STQTL11 cyclin-dependent kinase 6 亲和力捕获 - 韦斯特恩 Biogrid 11360184
CDKN1A CAP20 |CDKN1 |CIP1 |MDA-6 |p21 |SDI1 |WAF1 |P21CIP1 细胞周期蛋白依赖性激酶抑制剂1a（P21，CIP1） - HPRD 9858585
CKS1B CKS1 | PNAS-16 | PNAS-18 | ckshs1 CDC28 protein kinase regulatory subunit 1B 生化活动
重构的复合物		 Biogrid 12140288|12813041
COPS5 CSN5 |jab1 |MGC3149 |mov-34 |SGN5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 亲和力捕获 - 韦斯特恩 Biogrid 12082530
COPS5 CSN5 |jab1 |MGC3149 |mov-34 |SGN5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) COPS5（CSN5）与CDKN1B（P27）相互作用。 绑定 15688030
FOXO3 AF6Q21 |DKFZP781A0677 |fkhrl1 |fkhrl1p2 |FOXO2 |foxo3a |MGC12739 |MGC31925 叉子盒O3 FOXO3a interacts with p27Kip1 promoter. 绑定 15084260
GRB2 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 growth factor receptor-bound protein 2 - HPRD,BioGRID 11278754
KPNA2 IPOA1 | QIP2 | RCH1 | SRP1alpha 核桃蛋白α2（抹布队1，importin alpha 1） p27 interacts with importin-alpha. 绑定 15579463
NUP50 MGC39961 |NPAP60 |NPAP60L 核孔蛋白50KDA - HPRD,BioGRID 10891500
SKP2 fbl1 |fbxl1 |flb1 |MGC1366 S期激酶相关蛋白2（P45） - HPRD 10559916
SKP2 fbl1 |fbxl1 |flb1 |MGC1366 S期激酶相关蛋白2（P45） 亲和力捕获 - 韦斯特恩
生化活动
重构的复合物		 Biogrid 12042314|12140288
|12813041
SKP2 fbl1 |fbxl1 |flb1 |MGC1366 S期激酶相关蛋白2（P45） CDKN1B(p27Kip1) interacts with SKP2 (p45Skp2). 绑定 15735731
SKP2 fbl1 |fbxl1 |flb1 |MGC1366 S期激酶相关蛋白2（P45） SKP2与P27相互作用。 绑定 15469821
SPDYA MGC110856 |MGC57218 |ringo3 |spdy1 |spy1 快速同源物A（果蝇） 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 12972555
STMN1 LAP18 | Lag | OP18 | PP17 | PP19 | PR22 | SMN stathmin 1/oncoprotein 18 P27与Stathmin相互作用。 绑定 15652749
TRAF2 MGC：45012 |陷阱|陷阱3 TNF receptor-associated factor 2 Two-hybrid Biogrid 16189514
TSC1 KIAA0243 |林|MGC86987 |TSC tuberous sclerosis 1 亲和力捕获 - 韦斯特恩 Biogrid 15355997
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 亲和力捕获 - 韦斯特恩 Biogrid 15355997
UBB FLJ25987 | MGC8385 泛素b Ub interacts with p27. 绑定 15469821
UCHL1 park5 |pgp9.5 |UCH-L1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) - HPRD,BioGRID 12082530
XPO1 CRM1 |DKFZP686B1823 exportin 1 (CRM1 homolog, yeast) P27KIP1与CRM1相互作用。 绑定 11889117
XPO1 CRM1 |DKFZP686B1823 exportin 1 (CRM1 homolog, yeast) - HPRD,BioGRID 11889117|12529437
YWHAE 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，epsilon多肽 - HPRD 12042314
YWHAH YWHA1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide - HPRD 12042314
YWHAQ 14-3-3 | 1C5 | HS1 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，theta多肽 - HPRD,BioGRID 12042314


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
kegg细胞周期 128 84 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 89 75 All SZGR 2.0 genes in this pathway
KEGG慢性髓细胞性白血病 73 59 All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 84 67 All SZGR 2.0 genes in this pathway
BIOCARTA MCM PATHWAY 18 8 All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY 28 21 All SZGR 2.0 genes in this pathway
Biocarta CTCF途径 23 18 All SZGR 2.0 genes in this pathway
生物卡塔尔细胞途径 23 15 All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY 26 23 All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY 18 14 All SZGR 2.0 genes in this pathway
BIOCARTA P27 PATHWAY 13 10 All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号 67 54 All SZGR 2.0 genes in this pathway
SA G1和S阶段 15 10 All SZGR 2.0 genes in this pathway
SA REG CASCADE OF CYCLIN EXPR 13 7 All SZGR 2.0 genes in this pathway
pid rhoa途径 45 33 All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 74 48 All SZGR 2.0 genes in this pathway
PID RHOA REG PATHWAY 46 30 All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY 68 48 All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 49 43 All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 75 53 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
PID CMYB途径 84 61 All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY 35 30 All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 65 46 All SZGR 2.0 genes in this pathway
PID HNF3A PATHWAY 44 29 All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 48 39 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导 78 59 All SZGR 2.0 genes in this pathway
反应组细胞周期 421 253 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
Reactome ORC1从染色质中去除 67 37 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导 109 80 All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 38 28 All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome PI3K事件 44 34 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 97 66 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION 38 29 All SZGR 2.0 genes in this pathway
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 12 10 All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME 38 29 All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC 325 185 All SZGR 2.0 genes in this pathway
反应组细胞周期CHECKPOINTS 124 70 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 65 40 All SZGR 2.0 genes in this pathway
Reactome G1相 38 23 All SZGR 2.0 genes in this pathway
Reactome P53依赖G1 DNA损伤响应 57 35 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 92 53 All SZGR 2.0 genes in this pathway
Reactome有丝分裂G1 G1 S相 137 79 All SZGR 2.0 genes in this pathway
Reactome Pi 3K级联 56 39 All SZGR 2.0 genes in this pathway
REACTOME FGFR下游信号激活 100 74 All SZGR 2.0 genes in this pathway
Reactome DNA复制 192 110 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
Reactome Pip3激活Akt信号传导 29 20 All SZGR 2.0 genes in this pathway
REACTOME S PHASE 109 66 All SZGR 2.0 genes in this pathway
Reactome SCFSKP2介导的P27 P21降解 56 34 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导 112 80 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
Kim WT1靶向DN 459 276 All SZGR 2.0 genes in this pathway
kokkinakis蛋氨酸剥夺48小时 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 55 40 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC DN 14 12 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC UP 33 20 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 8HR 5 UP 16 7 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
Benporath循环基因 648 385 All SZGR 2.0 genes in this pathway
Shen Smarca2目标 424 268 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 52 40 All SZGR 2.0 genes in this pathway
Tenedini Megakaryocyte标记 66 48 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 51 35 All SZGR 2.0 genes in this pathway
HADDAD B淋巴细胞祖细胞 293 193 All SZGR 2.0 genes in this pathway
亚伯拉罕ALPC与多发性骨髓瘤 26 22 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 49 29 All SZGR 2.0 genes in this pathway
哈里斯缺氧 81 64 All SZGR 2.0 genes in this pathway
CUI TCF21靶向 37 27 All SZGR 2.0 genes in this pathway
伦纳德缺氧 47 35 All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上 428 266 All SZGR 2.0 genes in this pathway
SARTIPY BLUNTED BY INSULIN RESISTANCE DN 18 14 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160 101 All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定 491 310 All SZGR 2.0 genes in this pathway
由FOXP3绑定的Marson刺激 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
Marzec IL2信号传导DN 36 24 All SZGR 2.0 genes in this pathway
Matzuk luteal基因 8 5 All SZGR 2.0 genes in this pathway
LIN NPAS4靶向 163 100 All SZGR 2.0 genes in this pathway
冬季缺氧metagene 242 168 All SZGR 2.0 genes in this pathway
Bohn原发性免疫缺陷综合症 47 30 All SZGR 2.0 genes in this pathway
Schraets MLL靶向DN 33 24 All SZGR 2.0 genes in this pathway
Shaffer IRF4多发性骨髓瘤计划 36 25 All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 34 26 All SZGR 2.0 genes in this pathway
由MYC DN监管 253 192 All SZGR 2.0 genes in this pathway
dang myc针对DN 31 25 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
Browne HCMV感染1小时DN 222 147 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 2HR DN 49 33 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182 102 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP 61 41 All SZGR 2.0 genes in this pathway
Huang Gata2靶向 149 96 All SZGR 2.0 genes in this pathway
phong tnf响应不是通过p38 337 236 All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE 293 119 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-148/152 128 134 1A hsa-miR-148a ucagugcacuacaacuuugu
HSA-MIR-152brain UCAGUGCAUGACACUUGGG
hsa-miR-148b ucagugcaucacacaacuuugu
miR-186 427 433 1A HSA-MIR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-190 90 96 M8 HSA-MIR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-194 1301 1307 1A HSA-MIR-194 uguaacagcaacuccauga
miR-196 245 251 M8 HSA-MIR-196A uagguaguucauguugugug
HSA-MIR-196B UAGGUAGUUUCCUGUUGUUGG
mir-221/222 201 208 1A，M8 hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
miR-24 1253 1260 1A，M8 hsa-miR-24SZ uggcucucagagcaggaagag
mir-323 1275 1281 M8 hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-377 1278 1285 1A，M8 HSA-MIR-377 AUCACACAAAGGCAACUUUUGU
mir-455 279 285 1A hsa-miR-455 UAUGUGCCUUUGGACUACAUCG