Gene Page:Stub1
概括?
| 基因 | 10273 |
| 象征 | Stub1 |
| Synonyms | CHIP|HSPABP2|NY-CO-7|SCAR16|SDCCAG7|UBOX1 |
| Description | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase |
| Reference | MIM:607207|HGNC:HGNC:11427|Ensembl:ENSG00000103266|HPRD:06232|Vega:OTTHUMG00000121140 |
| Gene type | protein-coding |
| Map location | 16p13.3 |
| Pascal p-value | 0.033 |
| Sherlock p-value | 0.364 |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| Network | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | Contribution to shortest path in PPI network: 0.0239 |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf4 | 0.88 | 0.87 |
| PLA2G16 | 0.88 | 0.85 |
| SGK2 | 0.87 | 0.84 |
| MOG | 0.87 | 0.85 |
| ERBB3 | 0.87 | 0.87 |
| SLC48A1 | 0.87 | 0.85 |
| RHBDL2 | 0.86 | 0.81 |
| LDB3 | 0.86 | 0.84 |
| PADI2 | 0.86 | 0.84 |
| dbndd2 | 0.86 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NKIRAS2 | -0.61 | -0.61 |
| KIAA1949 | -0.60 | -0.60 |
| TUBB2B | -0.60 | -0.64 |
| HN1 | -0.60 | -0.63 |
| YBX1 | -0.60 | -0.68 |
| PPP1R14B | -0.60 | -0.71 |
| HMGB3 | -0.60 | -0.65 |
| MPP3 | -0.59 | -0.57 |
| FNBP1L | -0.58 | -0.59 |
| Dynlt1 | -0.58 | -0.70 |
Section III. Gene Ontology annotation
| 分子功能 | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去：0004842 | ubiquitin-protein ligase activity | TAS | 16307917 | |
| GO:0016874 | ligase activity | IEA | - | |
| GO:0010546 | Hsp90 protein inhibitor activity | IDA | 11146632 | |
| 去：0030674 | protein binding, bridging | TAS | 16307917 | |
| GO:0030544 | Hsp70 protein binding | IDA | 10330192 | |
| GO:0030544 | Hsp70 protein binding | TAS | 16307917 | |
| GO:0042803 | protein homodimerization activity | IEA | - | |
| GO:0030911 | TPR domain binding | IDA | 11146632 | |
| GO:0030191 | HSP70/HSC70蛋白抑制剂活性 | IDA | 10330192 | |
| GO：0046332 | SMAD binding | IDA | 15781469 | |
| GO:0051879 | Hsp90 protein binding | IDA | 11146632 | |
| GO:0051879 | Hsp90 protein binding | TAS | 16307917 | |
| 生物过程 | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000209 | protein polyubiquitination | IDA | 15781469 | |
| GO:0006457 | protein folding | TAS | 16307917 | |
| GO:0031943 | 调节糖皮质激素代谢过程 | IDA | 11146632 | |
| GO:0051604 | protein maturation | TAS | 16307917 | |
| GO:0031398 | positive regulation of protein ubiquitination | IDA | 11146632 | |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA | 11146632 | |
| 去：0030579 | ubiquitin-dependent SMAD protein catabolic process | IDA | 15781469 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0000151 | ubiquitin ligase complex | IEA | - | |
| GO:0005737 | 细胞质 | IDA | 10330192 | |
| GO:0031371 | ubiquitin conjugating enzyme complex | TAS | 16307917 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| BAG1 | RAP46 | BCL2-associated athanogene | - | HPRD,BioGRID | 11676916 |
| DNAJB1 | HSPF1 | Hdj1 | Hsp40 | Sis1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | - | HPRD,BioGRID | 10330192 |
| GPR37 | EDNRBL | PAELR | hET(B)R-LP | G protein-coupled receptor 37 (endothelin receptor type B-like) | - | HPRD,BioGRID | 12150907 |
| HSP90AA1 | FLJ31884 |HSP86 |HSP89A |HSP90A |HSP90N |HSPC1 |HSPCA |HSPCAL1 |HSPCAL4 |HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | - | HPRD | 11146632|11557750 |
| HSPA1A | FLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1B | 热休克70KDA蛋白1A | - | HPRD,BioGRID | 10330192 |
| HSPA4 | APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RY | heat shock 70kDa protein 4 | in vitro in vivo 两个杂交 |
BioGRID | 10330192 |
| HSPA8 | HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 | heat shock 70kDa protein 8 | - | HPRD,BioGRID | 10330192 |
| HSPA8 | HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 | heat shock 70kDa protein 8 | CHIP的TPR和带电域与HSC70的羧基末端区域相互作用。 | BIND | 10330192 |
| KHDRBS1 | FLJ34027 |SAM68 |p62 | KH domain containing, RNA binding, signal transduction associated 1 | 两个杂交 | BioGRID | 16169070 |
| MPP1 | AAG12 | DXS552 | DXS552E | EMP55 | MRG1 | PEMP | membrane protein, palmitoylated 1, 55kDa | 两个杂交 | BioGRID | 16169070 |
| SMAD1 | BSP1 | JV4-1 | JV41 | MADH1 | MADR1 | SMAD family member 1 | Smad1 interacts with CHIP. This interaction was modeled on a demonstrated interaction between Smad1 and CHIP, both from an unspecified species. | BIND | 15708501 |
| SMAD4 | DPC4 | JIP | MADH4 | SMAD family member 4 | Smad4 interacts with CHIP. This interaction was modeled on a demonstrated interaction between Smad1 and CHIP, both from an unspecified species. | BIND | 15708501 |
| UBE2D1 | E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5A | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | - | HPRD | 11557750 |
| UBE2D2 | E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | Reconstituted Complex | BioGRID | 11676916 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | 该途径中的所有SZGR 2.0基因 |
| PID ALPHA SYNUCLEIN PATHWAY | 33 | 25 | 该途径中的所有SZGR 2.0基因 |
| ERBB2的Reactome信号传导 | 101 | 78 | 该途径中的所有SZGR 2.0基因 |
| REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | 23 | 13 | 该途径中的所有SZGR 2.0基因 |
| REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | 26 | 16 | 该途径中的所有SZGR 2.0基因 |
| TGFβ受体复合物的反应组信号传导 | 63 | 42 | 该途径中的所有SZGR 2.0基因 |
| REACTOME IMMUNE SYSTEM | 933 | 616 | 该途径中的所有SZGR 2.0基因 |
| REACTOME适应性免疫系统 | 539 | 350 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 251 | 156 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 212 | 129 | 该途径中的所有SZGR 2.0基因 |
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP | 285 | 181 | 该途径中的所有SZGR 2.0基因 |
| HORIUCHI WTAP TARGETS DN | 310 | 188 | 该途径中的所有SZGR 2.0基因 |
| HU ANGIOGENESIS UP | 21 | 16 | 该途径中的所有SZGR 2.0基因 |
| BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR UP | 25 | 17 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH MYC MAX TARGETS | 775 | 494 | 该途径中的所有SZGR 2.0基因 |
| NIKOLSKY BREAST CANCER 16P13 AMPLICON | 120 | 49 | 该途径中的所有SZGR 2.0基因 |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | 该途径中的所有SZGR 2.0基因 |
| DANG BOUND BY MYC | 1103 | 714 | 该途径中的所有SZGR 2.0基因 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | 181 | 101 | 该途径中的所有SZGR 2.0基因 |
| LU EZH2 TARGETS UP | 295 | 155 | 该途径中的所有SZGR 2.0基因 |
| Acosta增殖独立MYC靶向 | 84 | 51 | 该途径中的所有SZGR 2.0基因 |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | 该途径中的所有SZGR 2.0基因 |
| Delacroix Rarg Bound MEF | 367 | 231 | 该途径中的所有SZGR 2.0基因 |
| ROESSLER LIVER CANCER METASTASIS UP | 107 | 72 | 该途径中的所有SZGR 2.0基因 |