Gene Page:SIGMAR1

Summary?
GeneID 10280
Symbol SIGMAR1
Synonyms ALS16|DSMA2|OPRS1|SIG-1R|SR-BP|SR-BP1|SRBP|hSigmaR1|sigma1R
Description sigma non-opioid intracellular receptor 1
Reference MIM:601978|HGNC:HGNC:8157|Ensembl:ENSG00000147955|HPRD:03580|Vega:OTTHUMG00000019829
Gene type protein-coding
Map location 9p13.3
Pascal p-value 0.087
Sherlock p-value 0.37
Fetal beta 0.267

Gene in Data Sources
Gene set name Method of gene set Description Info
ADT:Sun_2012 Systematic Investigation of Antipsychotic Drugs and Their Targets A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 有限公司-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NUP153 0.95 0.97
CKAP5 0.95 0.96
SEC31A 0.95 0.95
DYRK1A 0.95 0.96
CNOT1 0.94 0.97
STAU1 0.94 0.95
PUM1 0.94 0.96
HEATR5B 0.94 0.95
C4orf41 0.93 0.95
AP1G1 0.93 0.95
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.81 -0.89
AF347015.31 -0.80 -0.88
FXYD1 -0.80 -0.88
AF347015.33 -0.78 -0.85
IFI27 -0.77 -0.85
MT-CYB -0.77 -0.85
HIGD1B -0.76 -0.86
AF347015.8 -0.76 -0.87
AF347015.27 -0.76 -0.84
AF347015.21 -0.75 -0.89

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000247 C-8 sterol isomerase activity IEA -
GO:0004872 receptor activity IEA -
GO:0008144 药物绑定 TAS 8954936
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006696 ergosterol biosynthetic process IEA -
GO:0006869 lipid transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0042995 cell projection IEA axon (GO term level: 4) -
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005634 nucleus IEA -
GO:0005637 nuclear inner membrane IEA -
GO:0005640 nuclear outer membrane IEA -
GO:0005783 endoplasmic reticulum IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 8954936
GO:0012511 monolayer-surrounded lipid storage body IEA -
GO:0030054 cell junction IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PRAMOONJAGO SOX4 TARGETS DN 51 35 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP DN 35 20 All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE DN 51 35 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING DN 35 24 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN 103 71 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 480 MCF10A 39 20 All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 54 36 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
CREIGHTON内分泌治疗抵抗4 307 185 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P2 79 55 All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217 138 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210 123 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 105 63 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 525 531 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 525 531 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-153 551 558 1A,m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-205 12 18 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-214 116 122 m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-448 552 558 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU