Gene Page:APBB3

Summary?
GeneID 10307
Symbol APBB3
Synonyms FE65L2|SRA
Description amyloid beta precursor protein binding family B member 3
Reference MIM:602711|HGNC: HGNC: 20708|Ensembl:ENSG00000113108|HPRD:04089|Vega:OTTHUMG00000129504
Gene type protein-coding
Map location 5q31
Pascal p-value 3.065E-4
Sherlock p-value 0.652
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.0032

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10409262 chr19 58154954 APBB3 10307 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MEN1 0.95 0.94
RANBP3 0.94 0.94
EHMT2 0.94 0.94
U2AF2 0.94 0.94
CNOT3 0.94 0.94
SMPD4 0.94 0.94
EDC4 0.94 0.94
ZNF384 0.94 0.95
UNK 0.94 0.95
ZNF777 0.93 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.78 -0.86
MT-CO2 -0.76 -0.86
AF347015.27 -0.75 -0.85
AF347015.21 -0.73 -0.91
MT-CYB -0.72 -0.82
AF347015.33 -0.72 -0.81
AF347015.8 -0.72 -0.83
C5orf53 -0.71 -0.74
HIGD1B -0.70 -0.79
IFI27 -0.70 -0.76

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 10081969
GO:0005515 protein binding TAS 10081969
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007242 intracellular signaling cascade NAS -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton IDA 18029348
GO:0005575 cellular_component ND -
GO:0005737 cytoplasm IDA 18029348
GO:0005737 cytoplasm TAS 10081969

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LAIHO COLORECTAL CANCER SERRATED DN 86 47 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 142 93 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210 141 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 259 266 1A,m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-142-5p 272 279 1A,m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC