基因Page:KLF2

Summary?
基因ID 10365
Symbol KLF2
Synonyms LKLF
Description Kruppel-like factor 2
Reference MIM:602016|HGNC:HGNC:6347|Ensembl:ENSG00000127528|HPRD:03602|Vega:OTTHUMG00000182330
基因type protein-coding
Map location 19p13.11
Pascal p-value 0.157
Sherlock p-value 0.499
Fetal beta -0.107
eGene Myers' cis & trans

基因in Data Sources
基因set name 基因的方法设置 Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene 基因Entrez ID pvalue qvalue TSS distance eQTL type
rs17131472 chr1 91962966 KLF2 10365 3.594E-4 trans
rs546975 chr1 91963738 KLF2 10365 0.05 trans
rs1862058 chr2 16926283 KLF2 10365 0.15 trans
rs12612914 chr2 111666928 KLF2 10365 0.1 trans
rs2922180 chr3 125280472 KLF2 10365 0.06 trans
rs2976809 chr3 125451738 KLF2 10365 0 trans
rs9917710 chr3 176280218 KLF2 10365 0.09 trans
rs10050805 chr5 30805352 KLF2 10365 0.12 trans
rs837115 chr5 40736290 KLF2 10365 0.1 trans
rs16894149 chr5 61013724 KLF2 10365 0.17 trans
rs6449550 chr5 61034312 KLF2 10365 0.04 trans
rs17056435 chr5 158453782 KLF2 10365 0.11 trans
rs17135501 chr6 2704474 KLF2 10365 0.03 trans
rs17135521 chr6 2707631 KLF2 10365 0.03 trans
snp_a-1787926 0 KLF2 10365 0.03 trans
rs6934246 chr6 35154494 KLF2 10365 0.04 trans
rs4711782 chr6 44363229 KLF2 10365 0.15 trans
rs6455226 chr6 67930295 KLF2 10365 0 trans
rs12056282 chr7 18882202 KLF2 10365 0.14 trans
rs10085826 chr7 42504690 KLF2 10365 0.12 trans
rs2199402 chr8 9201002 KLF2 10365 0.08 trans
rs7841407 chr8 9243427 KLF2 10365 0.13 trans
rs680372 chr8 36999626 KLF2 10365 0.01 trans
rs2061799 chr9 97795003 KLF2 10365 0.12 trans
rs7081666 chr10 47673800 KLF2 10365 0.01 trans
rs1159612 chr10 85329057 KLF2 10365 2.005E-4 trans
rs10886877 chr10 85425690 KLF2 10365 0.11 trans
rs12359780 chr10 85446729 KLF2 10365 0.06 trans
rs10886943 chr10 85455847 KLF2 10365 0.08 trans
rs11199997 chr10 85456823 KLF2 10365 0.03 trans
rs11049036 chr12 27650292 KLF2 10365 0.02 trans
rs7303819 chr12 33990776 KLF2 10365 0.07 trans
rs10879027 chr12 70237156 KLF2 10365 0.03 trans
rs9529974 chr13 72821935 KLF2 10365 0.06 trans
rs17073665 chr13 81541961 KLF2 10365 0.05 trans
rs1457420 chr14 66958675 KLF2 10365 3.268E-4 trans
rs12880065 chr14 70747905 KLF2 10365 0.09 trans
rs17137819 chr16 5372534 KLF2 10365 0 trans
rs16958302 chr16 57647432 KLF2 10365 0.01 trans
rs9907183 chr17 9645471 KLF2 10365 0.17 trans
rs11873703 chr18 61448702 KLF2 10365 0.14 trans
rs2225630 chr20 10164852 KLF2 10365 0.02 trans
rs6095741 chr20 48666589 KLF2 10365 2.995E-8 trans
rs7265852 chr20 48823717 KLF2 10365 0.19 trans
rs1888534 chr21 46750189 KLF2 10365 0.15 trans
rs5915713 chrX 4077883 KLF2 10365 0.17 trans
rs5991662 chrX 43335796 KLF2 10365 0 trans
rs1545676 chrX 93530472 KLF2 10365 8.135E-5 trans
rs242163 chrX 132311662 KLF2 10365 0.07 trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
PTPRO 0.89 0.94
ANKRD44 0.88 0.90
C8orf79 0.87 0.88
DOPEY2 0.87 0.93
TRIM36 0.87 0.93
CEP170 0.86 0.95
MFAP3 0.86 0.92
ZEB2 0.86 0.83
SEMA3A 0.85 0.91
LRP12 0.85 0.93
Top 10 negatively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
AIFM3 -0.61 -0.81
HLA-F -0.61 -0.81
HEPN1 -0.61 -0.78
TSC22D4 -0.60 -0.82
C5orf53 -0.60 -0.74
SLC16A11 -0.60 -0.68
LHPP -0.60 -0.62
ALDOC -0.59 -0.71
CLU -0.59 -0.71
FBXO2 -0.59 -0.64

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN 50 36 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK UP 35 22 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 143 83 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 86 59 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176 123 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 67 45 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A DN 90 61 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186 107 All SZGR 2.0 genes in this pathway
CHASSOT SKIN WOUND 10 9 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN 165 104 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 40 HELA 42 29 All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 77 49 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197 110 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 66 47 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
YU MYC TARGETS DN 55 38 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 103 69 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 71 47 All SZGR 2.0 genes in this pathway
CHEN PDGF TARGETS 19 9 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 0HR 63 48 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245 148 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 69 46 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 147 98 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 49 34 All SZGR 2.0 genes in this pathway
MARSHALL VIRAL INFECTION RESPONSE DN 29 21 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE DN 57 36 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 4 31 17 All SZGR 2.0 genes in this pathway
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN 37 26 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP2 60 38 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 112 65 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 2 DN 32 23 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227 149 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR DN 55 35 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 114 69 All SZGR 2.0 genes in this pathway