Gene Page:CACNG2

Summary?
GeneID 10369
Symbol CACNG2
Synonyms MRD10
Description calcium voltage-gated channel auxiliary subunit gamma 2
Reference MIM:602911|HGNC:HGNC:1406|HPRD:04220|
Gene type protein-coding
Map location 22q13.1
Pascal p-value 0.104
Sherlock p-value 0.885
Fetal beta -1.374
Support CANABINOID
DOPAMINE
EXCITABILITY
METABOTROPIC GLUTAMATE RECEPTOR
SEROTONIN
G2Cdb.human_PocklingtonH1
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PAM 0.66 0.75
GRM8 0.66 0.71
SPOCK2 0.65 0.78
PDGFB 0.65 0.68
NHSL2 0.62 0.68
ARSG 0.62 0.67
B3GALTL 0.61 0.70
PRKCD 0.61 0.67
KCTD8 0.61 0.68
CCNE1 0.61 0.64
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NEUROD6 -0.44 -0.33
NEUROD2 -0.43 -0.30
KLHL1 -0.43 -0.20
RPL34 -0.41 -0.55
CSRP2 -0.41 -0.45
RPL38 -0.41 -0.55
RPL37 -0.41 -0.55
PFN3 -0.40 -0.42
RPL31 -0.40 -0.51
RPL37A -0.40 -0.53

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005509 calcium ion binding IEA -
GO:0005244 voltage-gated ion channel activity IEA -
GO:0005245 voltage-gated calcium channel activity TAS 10221464
GO:0005198 structural molecule activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007528 neuromuscular junction development IEA Synap (GO term level: 10) -
GO:0019226 transmission of nerve impulse IEA neuron (GO term level: 5) -
GO:0006816 calcium ion transport IEA -
GO:0006811 ion transport IEA -
GO:0042391 regulation of membrane potential IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005923 tight junction IEA Brain (GO term level: 10) -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane EXP 8825650
GO:0005891 voltage-gated calcium channel complex TAS 10221464

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG CARDIAC MUSCLE CONTRACTION 80 51 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 76 59 All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 92 68 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 28 23 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS WITH HCP H3K27ME3 102 76 All SZGR 2.0 genes in this pathway
MIKKELSEN ES HCP WITH H3 UNMETHYLATED 63 31 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228 119 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 158 164 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-375 200 206 1A hsa-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-450 102 108 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA