Gene Page:TUBA1B
Summary?
| GeneID | 10376 |
| Symbol | TUBA1B |
| Synonyms | K-ALPHA-1 |
| Description | tubulin alpha 1b |
| Reference | MIM:602530|HGNC:HGNC:18809|Ensembl:ENSG00000123416|HPRD:03960|Vega:OTTHUMG00000170410 |
| Gene type | protein-coding |
| Map location | 12q13.12 |
| Pascal p-value | 0.228 |
| Sherlock p-value | 0.573 |
| Fetal beta | -0.33 |
| DMG | 1 (# studies) |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14217534 | 12 | 49525474 | TUBA1B | 2.06E-9 | -0.014 | 1.65E-6 | DMG:Jaffe_2016 |
| cg21300561 | 12 | 49525534 | TUBA1B | 6.66E-8 | -0.01 | 1.64E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PRR12 | 0.97 | 0.98 |
| ZNF746 | 0.96 | 0.97 |
| SF1 | 0.96 | 0.96 |
| PHF12 | 0.95 | 0.96 |
| PPP1R10 | 0.95 | 0.96 |
| LSM14B | 0.95 | 0.96 |
| CREBBP | 0.95 | 0.97 |
| CCDC120 | 0.95 | 0.96 |
| KDM2B | 0.95 | 0.96 |
| USP42 | 0.95 | 0.96 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.77 | -0.90 |
| MT-CO2 | -0.76 | -0.90 |
| S100B | -0.75 | -0.85 |
| C5orf53 | -0.74 | -0.78 |
| AF347015.33 | -0.74 | -0.84 |
| AF347015.27 | -0.73 | -0.86 |
| FXYD1 | -0.73 | -0.85 |
| MT-CYB | -0.73 | -0.85 |
| HIGD1B | -0.72 | -0.87 |
| COPZ2 | -0.71 | -0.79 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | 源 | PubMed ID |
|---|---|---|---|---|---|
| CUL4A | - | cullin 4A | Affinity Capture-MS | BioGRID | 12481031 |
| FYN | MGC45350 | SLK | SYN | FYN oncogene related to SRC, FGR, YES | - | HPRD | 11826099 |
| GRM7 | FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7 | glutamate receptor, metabotropic 7 | - | HPRD | 11953448 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | - | HPRD | 7651436 |
| NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | - | HPRD | 9372968 |
| PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | - | HPRD,BioGRID | 7592789 |
| PXN | FLJ16691 | paxillin | - | HPRD | 10840040 |
| RBX1 | BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1 | ring-box 1 | Affinity Capture-MS | BioGRID | 12481031 |
| SIAH1 | FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1 | seven in absentia homolog 1 (Drosophila) | - | HPRD | 11146551 |
| SKI | SKV | v-ski sarcoma viral oncogene homolog (avian) | Ski interacts with alpha-tubulin. | BIND | 15806149 |
| SNAP91 | AP180 | CALM | DKFZp781O0519 | KIAA0656 | synaptosomal-associated protein, 91kDa homolog (mouse) | - | HPRD | 12750376 |
| STARD13 | DLC2 | FLJ37385 | GT650 | StAR-related lipid transfer (START) domain containing 13 | STARD13 (RhoGAP) interacts with K-ALPHA-1 (alpha-tubulin). | BIND | 14697242 |
| TUBG1 | TUBG | TUBGCP1 | tubulin, gamma 1 | - | HPRD | 11082048 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GAP JUNCTION | 90 | 68 | All SZGR 2.0 genes in this pathway |
| KEGG PATHOGENIC ESCHERICHIA COLI INFECTION | 59 | 36 | All SZGR 2.0 genes in this pathway |
| PID PRL SIGNALING EVENTS PATHWAY | 23 | 17 | All SZGR 2.0 genes in this pathway |
| PID HDAC CLASSII PATHWAY | 34 | 27 | All SZGR 2.0 genes in this pathway |
| PID HDAC CLASSIII PATHWAY | 25 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME PROTEIN FOLDING | 53 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 22 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | 19 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF PROTEINS | 518 | 242 | All SZGR 2.0 genes in this pathway |
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP | 285 | 181 | All SZGR 2.0 genes in this pathway |
| 通过CD40 HOLLMANN细胞凋亡 | 201 | 125 | All SZGR 2.0 genes in this pathway |
| LIU SOX4 TARGETS DN | 309 | 191 | All SZGR 2.0 genes in this pathway |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | 151 | 84 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS TOP50 UP | 38 | 27 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
| MATTIOLI MGUS VS PCL | 116 | 62 | All SZGR 2.0 genes in this pathway |
| MEINHOLD OVARIAN CANCER LOW GRADE DN | 20 | 16 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING VIA SMAD4 DN | 66 | 38 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM1 | 229 | 137 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| GROSS ELK3 TARGETS UP | 27 | 16 | All SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA ELK3 UP | 209 | 139 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| PETRETTO CARDIAC HYPERTROPHY | 34 | 26 | All SZGR 2.0 genes in this pathway |
| UEDA PERIFERAL CLOCK | 169 | 111 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | All SZGR 2.0 genes in this pathway |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
| IGLESIAS E2F TARGETS UP | 151 | 103 | All SZGR 2.0 genes in this pathway |
| WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 | 36 | 24 | All SZGR 2.0 genes in this pathway |
| YAMAZAKI TCEB3 TARGETS DN | 215 | 132 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA NORMAL | 311 | 205 | All SZGR 2.0 genes in this pathway |
| AMUNDSON GAMMA RADIATION RESISTANCE | 20 | 14 | All SZGR 2.0 genes in this pathway |
| HONMA DOCETAXEL RESISTANCE | 34 | 23 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| LABBE WNT3A TARGETS UP | 112 | 71 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR UP | 294 | 199 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL DN | 175 | 103 | All SZGR 2.0 genes in this pathway |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | 163 | 102 | All SZGR 2.0 genes in this pathway |
| KOBAYASHI EGFR SIGNALING 24HR DN | 251 | 151 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |