Gene Page:DLC1

Summary?
GeneID 10395
Symbol DLC1
Synonyms ARHGAP7|HP|STARD12|p122-RhoGAP
Description DLC1 Rho GTPase activating protein
Reference MIM:604258|HGNC:HGNC:2897|Ensembl:ENSG00000164741|HPRD:05035|Vega:OTTHUMG00000090825
Gene type protein-coding
Map location 8p22
Pascal p-value 0.281
Fetal beta -1.3
eGene Putamen basal ganglia
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 4

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2119908 8 12986249 DLC1 ENSG00000164741.10 7.275E-7 0.01 386918 gtex_brain_putamen_basal
rs4831399 8 12986826 DLC1 ENSG00000164741.10 3.099E-7 0.01 386341 gtex_brain_putamen_basal
rs7829204 8 12987236 DLC1 ENSG00000164741.10 3.612E-7 0.01 385931 gtex_brain_putamen_basal
rs62493016 8 12989691 DLC1 ENSG00000164741.10 4.536E-7 0.01 383476 gtex_brain_putamen_basal
rs10107321 8 12990422 DLC1 ENSG00000164741.10 5.572E-7 0.01 382745 gtex_brain_putamen_basal
rs13275331 8 12990518 DLC1 ENSG00000164741.10 5.729E-7 0.01 382649 gtex_brain_putamen_basal
rs17553586 8 12990818 DLC1 ENSG00000164741.10 2.91E-7 0.01 382349 gtex_brain_putamen_basal
rs13253885 8 12990948 DLC1 ENSG00000164741.10 6.633E-7 0.01 382219 gtex_brain_putamen_basal
rs6531026 8 12991625 DLC1 ENSG00000164741.10 3.735E-7 0.01 381542 gtex_brain_putamen_basal
rs10086729 8 12992111 DLC1 ENSG00000164741.10 4.382E-7 0.01 381056 gtex_brain_putamen_basal
rs13280448 8 12992763 DLC1 ENSG00000164741.10 5.456E-7 0.01 380404 gtex_brain_putamen_basal
rs12334796 8 12993284 DLC1 ENSG00000164741.10 6.6E-7 0.01 379883 gtex_brain_putamen_basal
rs10103017 8 12993815 DLC1 ENSG00000164741.10 4.974E-7 0.01 379352 gtex_brain_putamen_basal
rs10089272 8 12994259 DLC1 ENSG00000164741.10 1.084E-6 0.01 378908 gtex_brain_putamen_basal
rs6982268 8 12994642 DLC1 ENSG00000164741.10 5.386E-7 0.01 378525 gtex_brain_putamen_basal
rs7015013 8 12995743 DLC1 ENSG00000164741.10 9.996E-7 0.01 377424 gtex_brain_putamen_basal
rs12546051 8 12996469 DLC1 ENSG00000164741.10 1.104E-6 0.01 376698 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATP5L 0.88 0.89
TXN2 0.87 0.87
PSMB3 0.87 0.86
RBX1 0.87 0.86
MRPL11 0.86 0.86
EIF3K 0.86 0.87
SUCLG1 0.86 0.85
ICT1 0.85 0.83
ZNF32 0.85 0.81
ASNA1 0.85 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.26 -0.49 -0.52
SEMA3G -0.48 -0.49
EPAS1 -0.46 -0.50
ABCB1 -0.46 -0.48
FAM38A -0.46 -0.50
SLC6A12 -0.46 -0.49
MYH9 -0.45 -0.41
SHE -0.45 -0.48
FLT1 -0.45 -0.52
AF347015.2 -0.45 -0.47

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005096 GTPase activator activity IEA -
GO:0005515 protein binding 新闻学会 16951145
GO:0042169 SH2 domain binding 新闻学会 17190795
GO:0030675 Rac GTPase activator activity IDA 17932950
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0021575 hindbrain morphogenesis IEA Brain (GO term level: 9) -
GO:0021575 hindbrain morphogenesis ISS Brain (GO term level: 9) -
GO:0030900 forebrain development IEA Brain (GO term level: 8) -
GO:0030900 forebrain development ISS Brain (GO term level: 8) -
GO:0003007 heart morphogenesis IEA -
GO:0003007 heart morphogenesis ISS -
GO:0001843 neural tube closure IEA -
GO:0001843 neural tube closure ISS -
GO:0006917 induction of apoptosis IDA 17292327|17888903
GO:0007165 signal transduction IEA -
GO:0008285 negative regulation of cell proliferation IDA 12545165|17932950
GO:0008285 negative regulation of cell proliferation IMP 17292327
GO:0008360 regulation of cell shape IMP 17292327
GO:0048041 focal adhesion formation IEA -
GO:0048041 focal adhesion formation ISS -
GO:0006919 caspase activation IDA 17888903
GO:0030036 actin cytoskeleton organization IEA -
GO:0035024 负调节ρ蛋白质tr信号ansduction IMP 16951145
GO:0032956 regulation of actin cytoskeleton organization IMP 17292327
GO:0030336 negative regulation of cell migration IDA 17932950
GO:0030336 negative regulation of cell migration IMP 17292327|17888903
GO:0035307 positive regulation of protein amino acid dephosphorylation IDA 17292327
GO:0051497 negative regulation of stress fiber formation IDA 17932950
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005634 nucleus IDA 17888903
GO:0005737 cytoplasm IDA 16951145|17888903
GO:0005925 focal adhesion IDA 16951145|17190795
GO:0005901 caveola 新闻学会 16951145

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID RHOA REG PATHWAY 46 30. All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 113 81 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169 118 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 157 91 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194 122 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242 165 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 146 99 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN 209 122 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP 87 45 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181 101 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
ZIRN TRETINOIN RESPONSE WT1 UP 23 14 All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355 243 All SZGR 2.0 genes in this pathway
DACOSTA ERCC3 ALLELE XPCS VS TTD DN 36 27 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
SCHLESINGER METHYLATED DE NOVO IN CANCER 88 64 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292 168 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 68 44 All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191 131 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN 101 64 All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 49 34 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 30.7 185 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299 167 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295 149 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
SHEDDEN肺癌好生存A4 196 124 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
VALK AML WITH CEBPA 37 27 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 110 66 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 152 88 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 1737 1743 1A hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-1/206 2024 2030 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-101 1337 1343 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-130/301 1862 1868 1A hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-141/200a 1548 1554 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-144 1337 1343 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 197 203 1A hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d 1770 1776 1A hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-186 1721 1727 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 442 449 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-199 385 391 1A hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429 1367 1374 1A,m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-24 2045 2052 1A,m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-378 2085 2091 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-381 1701 1707 m8 hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-485-3p 1409 1416 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-495 1442 1448 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-539 415 421 1A hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU