Gene Page:CDSN
Summary?
| GeneID | 1041 |
| Symbol | CDSN |
| Synonyms | HTSS|HTSS1|HYPT2|PSS|PSS1|S |
| Description | corneodesmosin |
| Reference | MIM:602593|HGNC:HGNC:1802|Ensembl:ENSG00000204539|HPRD:03998|Vega:OTTHUMG00000031150 |
| Gene type | protein-coding |
| Map location | 6p21.3 |
| Pascal p-value | 2.073E-7 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16869851 | chr4 | 20690056 | CDSN | 1041 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CKAP2 | 0.83 | 0.83 |
| MYO3A | 0.82 | 0.48 |
| ATAD2 | 0.81 | 0.79 |
| C14orf106 | 0.81 | 0.73 |
| SGOL2 | 0.81 | 0.78 |
| CENPC1 | 0.79 | 0.77 |
| MLF1IP | 0.79 | 0.47 |
| SMARCA5 | 0.79 | 0.81 |
| SMC2 | 0.79 | 0.76 |
| RDX | 0.79 | 0.76 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.42 | -0.64 |
| CXCL14 | -0.41 | -0.63 |
| MT-CO2 | -0.41 | -0.64 |
| AF347015.2 | -0.41 | -0.62 |
| AF347015.8 | -0.40 | -0.62 |
| MT-CYB | -0.40 | -0.61 |
| IFI27 | -0.39 | -0.63 |
| AF347015.33 | -0.39 | -0.58 |
| COX4I2 | -0.38 | -0.59 |
| AF347015.15 | -0.38 | -0.60 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003674 | molecular_function | ND | - | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0042803 | protein homodimerization activity | IDA | 15086562 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0008544 | epidermis development | TAS | 9395522 | |
| GO:0008152 | metabolic process | IEA | - | |
| GO:0016337 | cell-cell adhesion | IDA | 11739386 | |
| GO:0030216 | keratinocyte differentiation | NAS | 8415725 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0001533 | cornified envelope | IDA | 9395522 | |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0030057 | desmosome | NAS | 9395522 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BERENJENO ROCK SIGNALING NOT VIA RHOA UP | 29 | 21 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS E DN | 22 | 12 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN | 110 | 64 | All SZGR 2.0 genes in this pathway |
| RICKMAN HEAD AND NECK CANCER C | 113 | 47 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| SMITH TERT TARGETS DN | 87 | 69 | All SZGR 2.0 genes in this pathway |
| MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN | 24 | 18 | All SZGR 2.0 genes in this pathway |
| PYEON CANCER HEAD AND NECK VS CERVICAL DN | 29 | 11 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN | 88 | 59 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |