Gene Page:YAP1

Summary?
GeneID 10413
Symbol YAP1
Synonyms COB1|YAP|YAP2|YAP65|YKI
Description Yes associated protein 1
Reference MIM:606608|HGNC:HGNC:16262|Ensembl:ENSG00000137693|HPRD:09424|Vega:OTTHUMG00000167322
Gene type protein-coding
Map location 11q13
Pascal p-value 0.276
Sherlock p-value 0.096
Fetal beta 1.1
DMG 2 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
Expression Meta-analysis of gene expression Pvalue: 3.166
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.6564

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01442799 11 101981050 YAP1 -0.026 0.28 DMG:Nishioka_2013
cg01442799 11 101981050 YAP1 3.24E-8 -0.008 9.74E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CGGBP1 0.90 0.91
KBTBD7 0.89 0.89
DLSTP 0.89 0.89
LEPROTL1 0.88 0.90
ASB7 0.88 0.88
ADNP2 0.88 0.89
PIP5K1A 0.88 0.89
DCTN4 0.88 0.88
MINPP1 0.88 0.88
PTPN9 0.88 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.71 -0.80
AF347015.31 -0.70 -0.79
AF347015.27 -0.68 -0.77
AF347015.8 -0.68 -0.80
MT-CYB -0.68 -0.78
AF347015.33 -0.68 -0.76
FXYD1 -0.68 -0.78
HSD17B14 -0.67 -0.73
HIGD1B -0.66 -0.77
AF347015.21 -0.66 -0.81

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 7644498
GO:0016563 transcription activator activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0045944 积极的监管of transcription from RNA polymerase II promoter IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005667 transcription factor complex IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
DENND3 KIAA0870 DENN/MADD domain containing 3 Two-hybrid BioGRID 11278422
ERBB4 HER4 | MGC138404 | p180erbB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) - HPRD,BioGRID 15023535
KIF5A D12S1889 | MY050 | NKHC | SPG10 kinesin family member 5A Two-hybrid BioGRID 11278422
NFE2 NF-E2 | p45 nuclear factor (erythroid-derived 2), 45kDa p45 interacts with hYAP. BIND 9305852
RUNX1 AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aB runt-related transcription factor 1 - HPRD,BioGRID 10228168
RUNX2 AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1 runt-related transcription factor 2 - HPRD,BioGRID 10228168
RUNX3 AML2 | CBFA3 | FLJ34510 | MGC16070 | PEBP2aC runt-related transcription factor 3 Reconstituted Complex BioGRID 10228168
SLC9A3R1 EBP50 | NHERF | NHERF1 | NPHLOP2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 - HPRD,BioGRID 10562288
SMAD7 CRCS3 | FLJ16482 | MADH7 | MADH8 SMAD family member 7 - HPRD,BioGRID 12118366
TEAD1 AA | REF1 | TCF13 | TEF-1 TEA domain family member 1 (SV40 transcriptional enhancer factor) - HPRD 11358867
TEAD2 ETF | TEF-4 | TEF4 TEA domain family member 2 - HPRD 11358867
TEAD3 DTEF-1 | ETFR-1 | TEAD5 | TEF-5 | TEF5 TEA domain family member 3 - HPRD 11358867
TEAD4 EFTR-2 | MGC9014 | RTEF1 | TCF13L1 | TEF-3 | TEFR-1 | hRTEF-1B TEA domain family member 4 - HPRD 11358867
TP53BP2 53BP2 | ASPP2 | BBP | PPP1R13A | p53BP2 tumor protein p53 binding protein, 2 - HPRD,BioGRID 11278422
TP63 AIS | B(p51A) | B(p51B) | EEC3 | KET | LMS | NBP | OFC8 | RHS | SHFM4 | TP53CP | TP53L | TP73L | p40 | p51 | p53CP | p63 | p73H | p73L 肿瘤的p63蛋白 Reconstituted Complex BioGRID 11278685
TP73 P73 tumor protein p73 - HPRD,BioGRID 11278685
TP73 P73 tumor protein p73 p73-alpha interacts with YAP. BIND 15893728
WBP1 MGC15305 | WBP-1 WW domain binding protein 1 in vitro
in vivo
Protein-peptide		 BioGRID 7644498|11604498
WBP2 MGC18269 | WBP-2 WW domain binding protein 2 in vitro BioGRID 7644498
YES1 HsT441 | P61-YES | Yes | c-yes v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 - HPRD 10562288
YWHAQ 14-3-3 | 1C5 | HS1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide - HPRD,BioGRID 12535517


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID ERBB4 PATHWAY 38 32 All SZGR 2.0 genes in this pathway
PID P73PATHWAY 79 59 All SZGR 2.0 genes in this pathway
PID DELTA NP63 PATHWAY 47 34 All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY 55 38 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR SIGNALING BY ERBB4 38 30 All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 104 72 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO 22 15 All SZGR 2.0 genes in this pathway
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 24 16 All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352 181 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205 140 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
SUZUKI AMPLIFIED IN ORAL CANCER 16 12 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS 37 27 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
DEBIASI由呼肠孤病毒感染细胞凋亡 314 201 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 DN 228 114 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193 112 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 1993 1999 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-21 1714 1721 1A,m8 hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa-miR-590 GAGCUUAUUCAUAAAAGUGCAG
miR-299-3p 652 658 1A hsa-miR-299-3p UAUGUGGGAUGGUAAACCGCUU
miR-299-5p 2776 2782 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-375 1683 1689 1A hsa-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-9 1663 1669 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA