Gene Page:PRMT5
概括?
| 基因 | 10419 |
| Symbol | PRMT5 |
| Synonyms | HRMT1L5|IBP72|JBP1|SKB1|SKB1Hs |
| Description | protein arginine methyltransferase 5 |
| Reference | MIM:604045|HGNC:HGNC:10894|Ensembl:ENSG00000100462|HPRD:04955|Vega:OTTHUMG00000028709 |
| Gene type | protein-coding |
| Map location | 14q11.2 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.087 |
| Support | Chromatin Remodeling Genes |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.047 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LITAF | 0.63 | 0.65 |
| ST5 | 0.62 | 0.63 |
| GM2A | 0.61 | 0.65 |
| CHST6 | 0.61 | 0.60 |
| PRR5L | 0.61 | 0.63 |
| SLC6A9 | 0.61 | 0.56 |
| CD44 | 0.60 | 0.59 |
| LAMP1 | 0.59 | 0.54 |
| CD82 | 0.59 | 0.59 |
| FAM63A | 0.59 | 0.56 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SATB2 | -0.33 | -0.25 |
| TTC9B | -0.33 | -0.34 |
| KLHL1 | -0.33 | -0.25 |
| NDUFAF2 | -0.33 | -0.41 |
| MEF2C | -0.33 | -0.26 |
| NOX1 | -0.33 | -0.35 |
| RPL9 | -0.33 | -0.35 |
| AC087071.1 | -0.32 | -0.38 |
| GNRHR | -0.32 | -0.36 |
| IER5L | -0.31 | -0.29 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0016740 | transferase activity | IEA | - | |
| GO:0008469 | histone-arginine N-methyltransferase activity | IEA | - | |
| GO:0008168 | methyltransferase activity | IDA | 15369763 | |
| 生物过程 | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000387 | spliceosomal snRNP biogenesis | 经验 | 15130578 | |
| 去：0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| 去：0006350 | transcription | IEA | - | |
| GO:0007088 | regulation of mitosis | TAS | 9843966 | |
| GO:0008283 | cell proliferation | TAS | 9843966 | |
| GO:0016568 | chromatin modification | IEA | - | |
| GO:0035246 | 肽基精氨酸N-甲基化 | IDA | 15369763 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005737 | cytoplasm | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CAPN1 | CANP | CANP1 | CANPL1 | muCANP | muCL | calpain 1, (mu/I) large subunit | CAPN1 interacts with SKB1. | BIND | 12358155 |
| CLNS1A | CLCI | CLNS1B | ICln | chloride channel, nucleotide-sensitive, 1A | - | HPRD | 9556550|11756452 |
| CLNS1A | CLCI | CLNS1B | ICln | chloride channel, nucleotide-sensitive, 1A | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex 两个杂交 |
BioGRID | 9556550|11713266 |11756452 |
| CTDP1 | CCFDN | FCP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | FCP1 interacts with PRMT5. | BIND | 15670829 |
| FBL | FIB | FLRN | RNU3IP1 | fibrillarin | Affinity Capture-MS | BioGRID | 14583623 |
| JAK1 | jak1a |jak1b |JTK3 | Janus kinase 1 (a protein tyrosine kinase) | - | HPRD,BioGRID | 10531356 |
| JAK2 | JTK10 | Janus kinase 2 (a protein tyrosine kinase) | - | HPRD,BioGRID | 10531356 |
| JAK3 | JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAK | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | - | HPRD,BioGRID | 10531356 |
| MBP | MGC99675 | myelin basic protein | - | HPRD,BioGRID | 11152681 |
| OLA1 | DKFZp313H1942 | GTPBP9 | PTD004 | Obg-like ATPase 1 | 两个杂交 | BioGRID | 16169070 |
| PHYHIP | DYRK1AP3 | KIAA0273 | PAHX-AP | PAHXAP1 | phytanoyl-CoA 2-hydroxylase interacting protein | 两个杂交 | BioGRID | 16169070 |
| PRMT5 | HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hs | protein arginine methyltransferase 5 | SKB1 forms homomeric complexes, including dimers and tetramers. | BIND | 11152681 |
| PRMT5 | HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hs | protein arginine methyltransferase 5 | - | HPRD,BioGRID | 10531356|11152681 |
| SNRPD1 | HsT2456 | SMD1 | SNRPD | 小型核核糖核蛋白D1 polypeptide 16kDa | - | HPRD,BioGRID | 11713266 |
| SNRPD3 | SMD3 | small nuclear ribonucleoprotein D3 polypeptide 18kDa | - | HPRD,BioGRID | 11713266 |
| SUPT5H | FLJ34157 | SPT5 | SPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | - | HPRD,BioGRID | 12718890 |
| TYK2 | JTK1 | 酪氨酸激酶2 | - | HPRD,BioGRID | 10531356 |
| WDR77 | HKMT1069 | MEP50 | MGC2722 | Nbla10071 | RP11-552M11.3 | p44 | WD repeat domain 77 | - | HPRD,BioGRID | 11756452 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID E2F PATHWAY | 74 | 48 | 该途径中的所有SZGR 2.0基因 |
| PID HDAC CLASSI PATHWAY | 66 | 50 | 该途径中的所有SZGR 2.0基因 |
| PID P53 REGULATION PATHWAY | 59 | 50 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF NON CODING RNA | 49 | 29 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF RNA | 330 | 155 | 该途径中的所有SZGR 2.0基因 |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | 该途径中的所有SZGR 2.0基因 |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | 该途径中的所有SZGR 2.0基因 |
| WANG LMO4 TARGETS DN | 352 | 225 | 该途径中的所有SZGR 2.0基因 |
| JAATINEN HEMATOPOIETIC STEM CELL UP | 316 | 190 | 该途径中的所有SZGR 2.0基因 |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | 该途径中的所有SZGR 2.0基因 |
| MARTORIATI MDM4 TARGETS FETAL LIVER UP | 227 | 137 | 该途径中的所有SZGR 2.0基因 |
| FURUKAWA DUSP6 TARGETS PCI35 DN | 74 | 40 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH MYC MAX TARGETS | 775 | 494 | 该途径中的所有SZGR 2.0基因 |
| SWEET KRAS TARGETS DN | 66 | 39 | 该途径中的所有SZGR 2.0基因 |
| MANALO HYPOXIA DN | 289 | 166 | 该途径中的所有SZGR 2.0基因 |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | 该途径中的所有SZGR 2.0基因 |
| Takao对UVB辐射DN的响应 | 98 | 67 | 该途径中的所有SZGR 2.0基因 |
| JIANG HYPOXIA CANCER | 83 | 52 | 该途径中的所有SZGR 2.0基因 |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | 该途径中的所有SZGR 2.0基因 |
| Creighton内分泌疗法抗性1 | 528 | 324 | 该途径中的所有SZGR 2.0基因 |
| Creighton内分泌疗法抗性4 | 307 | 185 | 该途径中的所有SZGR 2.0基因 |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | 该途径中的所有SZGR 2.0基因 |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | 该途径中的所有SZGR 2.0基因 |
| MARTINEZ RB1 TARGETS UP | 673 | 430 | 该途径中的所有SZGR 2.0基因 |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | 该途径中的所有SZGR 2.0基因 |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | 该途径中的所有SZGR 2.0基因 |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | 该途径中的所有SZGR 2.0基因 |
| MUELLER PLURINET | 299 | 189 | 该途径中的所有SZGR 2.0基因 |
| COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | 该途径中的所有SZGR 2.0基因 |
| BOYAULT LIVER CANCER SUBCLASS G3 UP | 188 | 121 | 该途径中的所有SZGR 2.0基因 |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | 277 | 172 | 该途径中的所有SZGR 2.0基因 |
| HOSHIDA LIVER CANCER SUBCLASS S1 | 237 | 159 | 该途径中的所有SZGR 2.0基因 |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | 该途径中的所有SZGR 2.0基因 |
| DANG BOUND BY MYC | 1103 | 714 | 该途径中的所有SZGR 2.0基因 |