Gene Page:CAP1

年代ummary?
GeneID 10487
年代ymbol CAP1
年代ynonyms CAP|CAP1-PEN
Description CAP, adenylate cyclase-associated protein 1 (yeast)
Reference HGNC:HGNC:20040|Ensembl:ENSG00000131236|HPRD:09869|Vega:OTTHUMG00000004493
Gene type protein-coding
Map location 1p34.2
Pascal p-value 0.897
年代herlock p-value 0.691
Fetal beta -0.585
年代upport INTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 年代ystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

年代ection I. Genetics and epigenetics annotation


年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
AC136297.1 0.84 0.83
CEBPB 0.83 0.86
KCNH3 0.82 0.81
LENG3 0.81 0.80
ASPHD1 0.80 0.85
DGKZ 0.80 0.79
GNPTG 0.80 0.82
VWA5B2 0.80 0.79
EPB49 0.79 0.75
CTSA 0.79 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
C11orf57 -0.62 -0.65
EXOSC8 -0.61 -0.66
FNBP1L -0.61 -0.48
FRG1 -0.61 -0.64
ZBED5 -0.60 -0.59
C9orf46 -0.60 -0.66
ZNF300 -0.60 -0.52
CYP2R1 -0.59 -0.63
RARS2 -0.59 -0.56
CCDC112 -0.59 -0.52

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA MPR PATHWAY 34 28 All SZGR 2.0 genes in this pathway
年代IG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 51 41 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 89 56 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR 30 26 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN 39 27 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 79 54 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
年代EIDEN MET SIGNALING 19 16 All SZGR 2.0 genes in this pathway
年代PIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261 155 All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 75 51 All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST GENETIC VARIANCE 37 21 All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS UP 43 24 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165 100 All SZGR 2.0 genes in this pathway
NOUZOVA TRETINOIN AND H4 ACETYLATION 143 85 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 86 57 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 100 72 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 1 DN 37 22 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 UP 81 52 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS DN 70 43 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS DN 28 18 All SZGR 2.0 genes in this pathway
NUTT GBM VS AO GLIOMA UP 46 34 All SZGR 2.0 genes in this pathway
年代CHRAETS MLL TARGETS DN 33 24 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 62 42 All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET UP 18 11 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA LB DN 44 23 All SZGR 2.0 genes in this pathway
金所有障碍少突细胞数量。柯尔 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194 133 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 106 77 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway