Gene Page:LRRC41

Summary?
GeneID 10489
Symbol LRRC41
Synonyms MUF1|PP7759
Description leucine rich repeat containing 41
Reference HGNC:HGNC:16917|Ensembl:ENSG00000132128|HPRD:10102|Vega:OTTHUMG00000007810
Gene type protein-coding
Map location 1p34.1
Pascal p-value 0.928
Sherlock p-value 0.976
Fetal beta -0.183
DMG 1 (# studies)
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09747578 1 46769076 LRRC41 1.22E-9 -0.015 1.3E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC005512.1 0.93 0.73
AP003108.2 0.92 0.44
PTPN7 0.91 0.15
PDE1B 0.91 0.77
TMEM90A 0.91 0.54
ADORA2A 0.89 -0.10
RASD2 0.89 0.74
LINGO3 0.88 0.75
WNT6 0.88 0.64
ANKRD34B 0.88 0.45
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BLVRA -0.25 -0.23
STMN1 -0.25 -0.29
PGBD1 -0.24 -0.37
KIAA1949 -0.24 -0.48
TUBB2B -0.24 -0.53
ZNF193 -0.23 -0.50
SH2B2 -0.23 -0.56
TUBB -0.23 -0.28
C19orf57 -0.23 -0.30
VAV2 -0.23 -0.43

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
PATTERSON DOCETAXEL RESISTANCE 29 20 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 105 63 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN 45 31 All SZGR 2.0 genes in this pathway
NUTT GBM VS AO GLIOMA UP 46 34 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE GENES 39 20 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway