Gene Page:ADARB2

年代ummary?
GeneID 105
年代ymbol ADARB2
年代ynonyms ADAR3|RED2
Description adenosine deaminase, RNA specific B2 (inactive)
Reference MIM:602065|HGNC:HGNC:227|Ensembl:ENSG00000185736|HPRD:09070|Vega:OTTHUMG00000017543
Gene type protein-coding
Map location 10p15.3
Pascal p-value 0.687
年代herlock p-value 0.218
DMG 2 (# studies)
eGene Cerebellum
Cortex
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 8
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 8

年代ection I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) 年代tudy
cg13504411 10 1596029 ADARB2 4.19E-5 0.637 0.021 DMG:Wockner_2014
cg19163058 10 1595785 ADARB2 4.54E-5 0.522 0.021 DMG:Wockner_2014
cg19533322 10 1595704 ADARB2 7.36E-5 0.546 0.025 DMG:Wockner_2014
cg20731819 10 1509859 ADARB2 1.043E-4 0.539 0.028 DMG:Wockner_2014
cg09265586 10 1595595 ADARB2 3.557E-4 0.518 0.042 DMG:Wockner_2014
cg17898884 10 1725190 ADARB2 4.249E-4 -0.603 0.045 DMG:Wockner_2014
cg05289540 10 1595989 ADARB2 5.013E-4 0.449 0.047 DMG:Wockner_2014
cg12557867 10 1779033 ADARB2 9.89E-8 -0.007 2.2E-5 DMG:Jaffe_2016


年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
年代USD5 0.83 0.78
年代IRPA 0.83 0.80
LRRK1 0.82 0.75
PACSIN1 0.81 0.75
IQSEC2 0.80 0.73
MICAL2 0.80 0.76
RASGRF2 0.80 0.77
CAMK2A 0.80 0.72
PDE8B 0.79 0.81
PIP5K1B 0.79 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
BCL7C -0.52 -0.59
EXOSC8 -0.49 -0.47
HEBP2 -0.49 -0.59
年代NHG12 -0.48 -0.52
C9orf46 -0.47 -0.50
RBMX2 -0.47 -0.47
C21orf57 -0.47 -0.50
RPS13P2 -0.47 -0.50
RPL23A -0.47 -0.50
LEMD1 -0.45 -0.35

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 103 58 All SZGR 2.0 genes in this pathway
年代CHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
年代HEPARD CRUSH AND BURN MUTANT DN 185 111 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
阿塞维多甲基化在肝癌DN 940 425 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 126 83 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 137 85 All SZGR 2.0 genes in this pathway
DEMAGALHAES AGING UP 55 39 All SZGR 2.0 genes in this pathway
DUAN PRDM5 TARGETS 79 52 All SZGR 2.0 genes in this pathway