Gene Page:CCT4
概括?
| 基因 | 10575 |
| 象征 | CCT4 |
| Synonyms | CCT-DELTA|Cctd|SRB |
| Description | 伴侣蛋白包含TCP1亚基4 |
| Reference | MIM:605142|HGNC:HGNC:1617|Ensembl:ENSG00000115484|HPRD：05506|织女:OTTHUMG00000152166 |
| Gene type | protein-coding |
| Map location | 2p15 |
| Pascal p-value | 0.733 |
| Sherlock p-value | 0.65 |
| Fetal beta | 0.159 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
| Support | RNA AND PROTEIN SYNTHESIS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP COMPOSITESET |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10736404 | 2 | 62115920 | CCT4 | 1.228E-4 | -0.203 | 0.03 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| rs6586487 | chr1 | 18339747 | CCT4 | 10575 | 0.14 | trans | ||
| rs17472583 | chr1 | 18340024 | CCT4 | 10575 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ERCC6L | 0.95 | 0.78 |
| KNTC1 | 0.95 | 0.90 |
| SMC4 | 0.95 | 0.90 |
| CHEK1 | 0.95 | 0.88 |
| FBXO5 | 0.95 | 0.87 |
| HELLS | 0.95 | 0.80 |
| FANCI | 0.95 | 0.73 |
| RBL1 | 0.95 | 0.83 |
| BUB1B | 0.95 | 0.83 |
| KIF23 | 0.95 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HLA-F | -0.54 | -0.79 |
| C5orf53 | -0.52 | -0.72 |
| FBXO2 | -0.51 | -0.66 |
| AF347015.31 | -0.51 | -0.85 |
| AIFM3 | -0.51 | -0.75 |
| AF347015.27 | -0.51 | -0.84 |
| PTH1R | -0.51 | -0.73 |
| MT-CO2 | -0.51 | -0.87 |
| S100B | -0.51 | -0.80 |
| AF347015.33 | -0.51 | -0.84 |
第四节。蛋白质蛋白相互作用注释
| 互动者 | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| acta1 | ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3 | actin, alpha 1, skeletal muscle | - | HPRD,BioGRID | 11580270 |
| acta2 | AAT6 | ACTSA | actin, alpha 2, smooth muscle, aorta | - | HPRD,BioGRID | 11580270 |
| CCNE1 | CCNE | cyclin E1 | - | HPRD,BioGRID | 9819444 |
| CCT3 | CCT-gamma | CCTG | PIG48 | TCP-1-gamma | TRIC5 | chaperonin containing TCP1, subunit 3 (gamma) | - | HPRD | 7953530 |
| IGBP1 | ALPHA-4 | IBP1 | immunoglobulin (CD79A) binding protein 1 | 亲和力捕获ms | BioGRID | 16085932 |
| PPP2CA | pp2ac |pp2ca |RP-C | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 亲和力捕获ms | BioGRID | 18782753 |
| PPP2CB | PP2CB | protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform | 亲和力捕获ms | BioGRID | 18782753 |
| PPP2R2C | B55-GAMMA | IMYPNO | IMYPNO1 | MGC33570 | PR52 | PR55G | protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform | 亲和力捕获ms | BioGRID | 18782753 |
| PPP4C | PP4 | PPH3 | PPX | protein phosphatase 4 (formerly X), catalytic subunit | 亲和力捕获ms | BioGRID | 16085932|18715871 |
| STK24 | MST-3 | MST3 | MST3B | STE20 | STK3 | 丝氨酸/苏氨酸激酶24（Ste20同源物，酵母） | 亲和力捕获ms | BioGRID | 18782753 |
| STRN | MGC125642 | SG2NA | striatin, calmodulin binding protein | 亲和力捕获ms | BioGRID | 18782753 |
| strn3 | SG2NA | striatin, calmodulin binding protein 3 | 亲和力捕获ms | BioGRID | 18782753 |
| TCP1 | CCT-alpha | CCT1 | CCTa | D6S230E | TCP-1-alpha | t-complex 1 | 亲和力捕获ms | BioGRID | 16085932 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA BCELLSURVIVAL PATHWAY | 16 | 10 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | 27 | 15 | 该途径中的所有SZGR 2.0基因 |
| REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | 28 | 15 | 该途径中的所有SZGR 2.0基因 |
| REACTOME PROTEIN FOLDING | 53 | 30 | 该途径中的所有SZGR 2.0基因 |
| REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 22 | 11 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF PROTEINS | 518 | 242 | 该途径中的所有SZGR 2.0基因 |
| 多德鼻咽癌DN | 1375 | 806 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | 该途径中的所有SZGR 2.0基因 |
| DARWICHE SKIN TUMOR PROMOTER UP | 142 | 96 | 该途径中的所有SZGR 2.0基因 |
| DARWICHE PAPILLOMA RISK LOW DN | 165 | 107 | 该途径中的所有SZGR 2.0基因 |
| Darwiche Papilloma风险高 | 147 | 101 | 该途径中的所有SZGR 2.0基因 |
| darwiche鳞状细胞癌 | 146 | 104 | 该途径中的所有SZGR 2.0基因 |
| Mattioli Mgus vs PCL | 116 | 62 | 该途径中的所有SZGR 2.0基因 |
| MATTIOLI MGUS VS MULTIPLE MYELOMA | 16 | 11 | 该途径中的所有SZGR 2.0基因 |
| patil肝癌 | 747 | 453 | 该途径中的所有SZGR 2.0基因 |
| TSAI对电离辐射的响应 | 149 | 101 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | 该途径中的所有SZGR 2.0基因 |
| 洛佩兹MBD目标 | 957 | 597 | 该途径中的所有SZGR 2.0基因 |
| Sakai肿瘤浸润单核细胞DN | 81 | 51 | 该途径中的所有SZGR 2.0基因 |
| PENG LEUCINE DEPRIVATION DN | 187 | 122 | 该途径中的所有SZGR 2.0基因 |
| TARTE PLASMA CELL VS PLASMABLAST DN | 309 | 206 | 该途径中的所有SZGR 2.0基因 |
| SANA RESPONSE TO IFNG DN | 85 | 56 | 该途径中的所有SZGR 2.0基因 |
| PENG GLUCOSE DEPRIVATION DN | 169 | 112 | 该途径中的所有SZGR 2.0基因 |
| PENG RAPAMYCIN RESPONSE DN | 245 | 154 | 该途径中的所有SZGR 2.0基因 |
| ZHAN MULTIPLE MYELOMA SUBGROUPS | 30 | 20 | 该途径中的所有SZGR 2.0基因 |
| ASTIER INTEGRIN SIGNALING | 59 | 44 | 该途径中的所有SZGR 2.0基因 |
| NADLER HYPERGLYCEMIA AT OBESITY | 58 | 35 | 该途径中的所有SZGR 2.0基因 |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 该途径中的所有SZGR 2.0基因 |
| 罗德斯癌元签名 | 64 | 47 | 该途径中的所有SZGR 2.0基因 |
| Mody海马新生儿 | 35 | 25 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT DN | 165 | 106 | 该途径中的所有SZGR 2.0基因 |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | 该途径中的所有SZGR 2.0基因 |
| VISALA RESPONSE TO HEAT SHOCK AND AGING DN | 14 | 12 | 该途径中的所有SZGR 2.0基因 |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 180 | 114 | 该途径中的所有SZGR 2.0基因 |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | 该途径中的所有SZGR 2.0基因 |
| RIZKI TUMOR INVASIVENESS 2D DN | 64 | 35 | 该途径中的所有SZGR 2.0基因 |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | 该途径中的所有SZGR 2.0基因 |
| 米利假足 | 518 | 299 | 该途径中的所有SZGR 2.0基因 |
| 肌肉中的罗马胰岛素靶标 | 442 | 263 | 该途径中的所有SZGR 2.0基因 |
| BOYAULT LIVER CANCER SUBCLASS G3 UP | 188 | 121 | 该途径中的所有SZGR 2.0基因 |
| 清肝癌亚类未注释的DN | 193 | 112 | 该途径中的所有SZGR 2.0基因 |
| 开罗肝母细胞瘤上课 | 605 | 377 | 该途径中的所有SZGR 2.0基因 |
| WINNEPENNINCKX MELANOMA METASTASIS UP | 162 | 86 | 该途径中的所有SZGR 2.0基因 |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | 该途径中的所有SZGR 2.0基因 |
| LEE BMP2 TARGETS DN | 882 | 538 | 该途径中的所有SZGR 2.0基因 |
| BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2 | 73 | 37 | 该途径中的所有SZGR 2.0基因 |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | 该途径中的所有SZGR 2.0基因 |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | 该途径中的所有SZGR 2.0基因 |
| FU INTERACT WITH ALKBH8 | 13 | 8 | 该途径中的所有SZGR 2.0基因 |