Gene Page:ERN2

Summary?
GeneID 10595
Symbol ERN2
Synonyms IRE1-BETA|IRE1b|IRE2p|hIRE2p
Description endoplasmic reticulum to nucleus signaling 2
Reference MIM:604034|HGNC:HGNC:16942|Ensembl:ENSG00000134398|HPRD:04944|Vega:OTTHUMG00000177020
Gene type protein-coding
Map location 16p12.2
Pascal p-value 0.243
Fetal beta -0.119
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01775

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05131483 16 23706242 ERN2 4.503E-4 -0.352 0.045 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ENOSF1 0.61 0.53
CHD1L 0.61 0.58
BEST1 0.59 0.53
KIAA1755 0.58 0.58
CDC14B 0.58 0.56
CYTSB 0.58 0.57
CA14 0.57 0.56
IGSF11 0.57 0.52
FAM63A 0.56 0.51
LITAF 0.56 0.53
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C1orf86 -0.40 -0.44
EMID1 -0.38 -0.42
AC011491.1 -0.35 -0.39
RPRM -0.34 -0.38
RASGEF1C -0.34 -0.32
CD1D -0.34 -0.36
COMTD1 -0.34 -0.37
GPRIN1 -0.33 -0.32
SLC1A6 -0.33 -0.38
LRFN4 -0.33 -0.35

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IDA 11175748
GO:0005524 ATP binding IDA 11175748
GO:0004519 endonuclease activity IDA 11175748
GO:0004674 protein serine/threonine kinase activity IDA 11175748
GO:0016787 hydrolase activity IEA -
GO:0016740 transferase activity IEA -
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006397 mRNA processing IEA -
GO:0006468 protein amino acid phosphorylation IDA 11175748
GO:0016075 rRNA catabolic process IDA 11175748
GO:0006917 induction of apoptosis IMP 11175748
GO:0006950 response to stress IEA -
GO:0007050 cell cycle arrest IEA -
GO:0006915 apoptosis IEA -
GO:0016481 negative regulation of transcription IMP 11175748
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005783 endoplasmic reticulum IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216 124 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway