Summary
基因 10611
象征 pDLIM5
Synonyms ENH | ENH1 | L9 | LIM
Description PDZ和LIM域5
Reference MIM:605904|HGNC:HGNC:17468|ENSEMBL:ENSG00000163110|HPRD:05799|Vega:Otthumg00000130973
基因类型 蛋白质编码
Map location 4Q22
Pascal P值 0.496
Sherlock p-value 0.491
胎儿β 0.238
主持人 尾状基底神经节

Gene in Data Sources
基因集名称 Method of gene set Description 信息
简历:PGCNP 全基因组协会研究 GWAS
PMID:cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
协会 A combined odds ratio method (Sun等。2008), association studies 2 链接到SZGene
表达 Meta-analysis of gene expression p价值:1.438
Literature High-throughput literature-search 与精神分裂症关键词共同存在:精神分裂症,精神分裂症,精神分裂症,精神分裂症 点击显示详细信息

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达(GTEX)

无法使用

Devlopment期间的基因表达(BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达(brainspan)

Footnote:
SC:亚皮质区域;SM:感觉运动区域;FC:额叶皮层;和TP:颞顶皮层
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene 皮尔逊的相关性 斯皮尔曼的相关性
prkar2b 0.85 0.90
vldlr 0.84 0.90
KIAA1383 0.83 0.86
terf2 0.83 0.88
GALNT2 0.83 0.83
STX6 0.83 0.89
SH3BP5 0.82 0.88
myt1l 0.82 0.89
Arih1 0.82 0.87
ZNF248 0.82 0.87
前10个负共表达基因
Gene 皮尔逊的相关性 斯皮尔曼的相关性
MT-CO2 -0.73 -0.81
AF347015.31 -0.72 -0.80
AF347015.33 -0.71 -0.78
AF347015.8 -0.70 -0.80
mt-cyb -0.70 -0.78
HSD17B14 -0.70 -0.78
FXYD1 -0.70 -0.80
HIGD1B -0.70 -0.81
AF347015.27 -0.70 -0.78
AIFM3 -0.69 -0.75

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0003779 肌动蛋白结合 ISS -
去:0005080 蛋白激酶C结合 ISS -
去:0005515 蛋白质结合 IEA -
去:0008270 锌离子结合 IEA -
GO:0042805 阳历原结合 ISS -
GO:0046872 metal ion binding IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0005829 细胞质 ISS -
去:0005624 膜分数 ISS -
去:0030018 Z光盘 IEA -
GO:0015629 肌动蛋白细胞骨架 艾达 11256614

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Piccaluga血管免疫细胞淋巴瘤 205 140 All SZGR 2.0 genes in this pathway
刘前列腺癌 96 57 All SZGR 2.0 genes in this pathway
Liu Sox4靶向DN 309 191 All SZGR 2.0 genes in this pathway
THUM收缩心力衰竭DN 244 147 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
LAIHO大肠癌锯齿状的D UP 112 71 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
Mullighan NPM1签名3 341 197 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合HSC的TONKS目标UP 185 126 All SZGR 2.0 genes in this pathway
Lee神经Crest干细胞DN 118 79 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
Nagashima NRG1信号向上发出 176 123 All SZGR 2.0 genes in this pathway
Kim WT1靶向 214 155 All SZGR 2.0 genes in this pathway
甲状腺癌的Rodrigues分化不佳的DN 805 505 All SZGR 2.0 genes in this pathway
甲状腺癌变性DN 537 339 All SZGR 2.0 genes in this pathway
Gozgit ESR1靶向DN 781 465 All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶标C向上 170 114 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207 128 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
PAX3 FOXO1融合的Ebauer肌原靶标 50 26 All SZGR 2.0 genes in this pathway
Seitz肿瘤转化通过8p删除 73 47 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
王HCP前列腺癌 111 69 All SZGR 2.0 genes in this pathway
Tomlins前列腺癌 40 27 All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲DN 584 395 All SZGR 2.0 genes in this pathway
通过ELK3 DN的缺氧总缺氧 156 106 All SZGR 2.0 genes in this pathway
仅通过ELK3的高缺氧 33 18 All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN 637 377 All SZGR 2.0 genes in this pathway
Amit EGF响应240 HELA 60 43 All SZGR 2.0 genes in this pathway
Amit EGF响应480 HELA 164 118 All SZGR 2.0 genes in this pathway
Amit EGF响应60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
Amit EGF响应120 MCF10A 43 28 All SZGR 2.0 genes in this pathway
阿米特血清反应60 mcf10a 57 42 All SZGR 2.0 genes in this pathway
阿米特血清反应120 MCF10A 65 44 All SZGR 2.0 genes in this pathway
阿米特血清反应240 MCF10A 57 36 All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION G1 G2 UP 12 9 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
Fab M7类型的Ross Aml 68 44 All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn 546 351 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植被拒绝与OK 63 48 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
Wang Smarce1靶向DN 371 218 All SZGR 2.0 genes in this pathway
大脑衰老 262 186 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
Kaab心脏中心与心室DN 261 183 All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN 434 302 All SZGR 2.0 genes in this pathway
dazard UV响应集群G1 67 41 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向 673 430 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向 601 369 All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜 425 298 All SZGR 2.0 genes in this pathway
p210 bcr abl融合的射线目标 18 13 All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 88 56 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
gregory合成致死与伊马替尼 145 83 All SZGR 2.0 genes in this pathway
Hoelzel NF1靶向 139 93 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
pasini suz12靶向DN 315 215 All SZGR 2.0 genes in this pathway
ewsr1 fli1融合的骨靶标 271 165 All SZGR 2.0 genes in this pathway
phong tnf响应不是通过p38 337 236 All SZGR 2.0 genes in this pathway
Zwang 1类由EGF瞬时诱导 516 308 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-15/16/195/424/497 2376 2382 M8 HSA-MIR-15Abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain uagcagcacaucaugguuaca
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 Cagcagcaauucauguuuugaa
HSA-MIR-497 cagcagcacacuguguuugu