Gene Page:CGRRF1

Summary?
GeneID 10668
Symbol CGRRF1
Synonyms CGR19|RNF197
Description cell growth regulator with ring finger domain 1
Reference MIM:606138|HGNC:HGNC:15528|Ensembl:ENSG00000100532|HPRD:09366|Vega:OTTHUMG00000140308
Gene type protein-coding
Map location 14q22.2
Pascal p-value 0.295
Sherlock p-value 0.339
Fetal beta -0.794
DMG 2 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14098132 14 54976507 CGRRF1 1.75E-8 -0.01 6.33E-6 DMG:Jaffe_2016
cg24256211 14 55035215 CGRRF1 9.376E-4 3.412 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PADI2 0.92 0.91
GPRC5B 0.92 0.91
TTYH2 0.92 0.89
ERBB3 0.92 0.88
PMP22 0.91 0.92
SLC48A1 0.90 0.88
LDB3 0.90 0.84
SGK2 0.90 0.84
CPM 0.89 0.88
GLTP 0.89 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NKIRAS2 -0.59 -0.57
MED19 -0.59 -0.69
NR2C2AP -0.59 -0.67
HN1 -0.58 -0.64
STMN1 -0.58 -0.63
YBX1 -0.57 -0.66
TUBB2B -0.57 -0.60
CRMP1 -0.57 -0.57
POLB -0.57 -0.68
KIAA1949 -0.57 -0.54

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PUIFFE INVASION INHIBITED BY ASCITES DN 145 91 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP 57 35 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 111 68 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 145 93 All SZGR 2.0 genes in this pathway
EHLERS ANEUPLOIDY UP 41 29 All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND HD MTX DN 25 18 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 166 97 All SZGR 2.0 genes in this pathway