基因Page:MAP3K2

概括?
基因ID 10746
Symbol MAP3K2
同义词 MEKK2|MEKK2B
描述 mitogen-activated protein kinase kinase kinase 2
参考 MIM:609487|HGNC：HGNC：6854|Ensembl:ENSG00000169967|HPRD:10068|Vega:OTTHUMG00000153397
基因type protein-coding
地图位置 2q14.3
Pascal P值 0.985
Sherlock P值 0.023
Fetal beta 0.874
eGene 迈尔斯的顺式和跨性别
Meta

数据源中的基因
基因集名称 基因组方法 描述 Info
GSMA_I 基因组扫描荟萃分析 PSR：0.023
GSMA_IIA 基因组扫描荟萃分析（所有样品） PSR：0.00755

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene 基因Entrez ID pvalue qvalue TSS distance eQTL type
RS2404535 chr2 127947708 MAP3K2 10746 0.14 cis
rs7585198 chr2 127962634 MAP3K2 10746 0 cis
rs12463909 chr2 127971737 MAP3K2 10746 0.01 cis
rs4150477 chr2 128032545 MAP3K2 10746 0.04 cis
rs6710535 chr2 128190959 MAP3K2 10746 0.03 cis
rs7585198 chr2 127962634 MAP3K2 10746 0.13 trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
PYGO2 0.85 0.87
MAGED1 0.85 0.87
KIAA1539 0.82 0.83
AC069234.1 0.82 0.87
ZMYM3 0.82 0.86
VAC14 0.81 0.85
C7orf43 0.81 0.85
EFNB3 0.81 0.85
LRRN2 0.81 0.85
RGMB 0.81 0.84
Top 10 negatively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
MT-CO2 -0.68 -0.73
AF347015.8 -0.66 -0.73
AF347015.31 -0.66 -0.70
AF347015.21 -0.66 -0.76
AF347015.2 -0.65 -0.70
MT-CYB -0.64 -0.68
AF347015.33 -0.63 -0.68
AF347015.27 -0.63 -0.69
AF347015.15 -0.62 -0.67
AF347015.26 -0.62 -0.68

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 核苷酸结合 IEA -
GO:0000287 magnesium ion binding IEA -
GO:0005515 protein binding IEA -
GO:0005524 ATP binding IEA -
GO:0004672 protein kinase activity IEA -
GO:0004674 蛋白质丝氨酸/苏氨酸激酶活性 塔斯 8621389
去：0004709 MAP kinase kinase kinase activity IEA -
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 蛋白氨基酸磷酸化 IEA -
GO:0007257 activation of JNK activity 塔斯 8621389
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 核 IEA -
GO:0005737 细胞质 IEA -

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
MAP2K4 jnkk |jnkk1 |MAPKK4 |MEK4 |MKK4 |prkmk4 |sek1 |SERK1 mitogen-activated protein kinase kinase 4 - HPRD 7997270
MAP2K5 HsT17454 | MAPKK5 | MEK5 | PRKMK5 mitogen-activated protein kinase kinase 5 Affinity Capture-Western
两个杂交		 BioGRID 11073940
MAP2K5 HsT17454 | MAPKK5 | MEK5 | PRKMK5 mitogen-activated protein kinase kinase 5 MEKK2 phosphorylates an unspecified isoform of MEK5. This interaction was modeled on a demonstrated interaction between MEKK2 from an unspecified species and MEK5 from an unspecified species. BIND 12659851
MAP2K7 Jnkk2 | MAPKK7 | MKK7 | PRKMK7 mitogen-activated protein kinase kinase 7 MEKK2 phosphorylates MKK7. This interaction was modeled on a demonstrated interaction between MEKK2 from an unspecified species and MKK7 from an unspecified species. BIND 12659851
MAP2K7 Jnkk2 | MAPKK7 | MKK7 | PRKMK7 mitogen-activated protein kinase kinase 7 - HPRD，Biogrid 10713157
MAP3K2 MEKK2 | MEKK2B mitogen-activated protein kinase kinase kinase 2 MEKK2自磷酸化。这种相互作用是基于未指定物种的MEKK2相互作用进行建模的。 BIND 12659851
MAP3K5 ASK1 | MAPKKK5 | MEKK5 mitogen-activated protein kinase kinase kinase 5 - HPRD 12912994
MAPK8 JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 mitogen-activated protein kinase 8 - HPRD，Biogrid 10713157
PKN2 MGC150606 |MGC71074 |pak2 |prk2 |prkcl2 |Pro2042 |PAK-2 蛋白激酶N2 - HPRD，Biogrid 10818102
SFN 是的 stratifin 亲和力捕获ms BioGRID 15778465
SH2D2A F2771 | TSAd SH2域蛋白2A Affinity Capture-Western
两个杂交		 BioGRID 11073940
是的 14-3-3e |FLJ45465 |KCIP-1 |MDCR |MDS tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide - HPRD，Biogrid 9452471
是的 14-3-3GAMMA 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，伽马多肽 - HPRD 15324660
ywhaz KCIP-1 |MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide - HPRD 9452471


V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG MAPK SIGNALING PATHWAY 267 205 该途径中的所有SZGR 2.0基因
kegg间隙交界处 90 68 该途径中的所有SZGR 2.0基因
KEGG GNRH SIGNALING PATHWAY 101 77 该途径中的所有SZGR 2.0基因
BIOCARTA MAPK PATHWAY 87 68 该途径中的所有SZGR 2.0基因
ST JNK MAPK PATHWAY 40 30 该途径中的所有SZGR 2.0基因
PID ERBB1下游途径 105 78 该途径中的所有SZGR 2.0基因
PID MAPK TRK途径 34 31 该途径中的所有SZGR 2.0基因
奥斯曼膀胱癌 404 246 该途径中的所有SZGR 2.0基因
胶原蛋白凝胶DN中的Oswald造血干细胞 275 168 该途径中的所有SZGR 2.0基因
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 54 38 该途径中的所有SZGR 2.0基因
SENESE HDAC1 TARGETS UP 457 269 该途径中的所有SZGR 2.0基因
Senese HDAC3靶向 501 327 该途径中的所有SZGR 2.0基因
HAMAI APOPTOSIS VIA TRAIL UP 584 356 该途径中的所有SZGR 2.0基因
Nuytten Nipp1靶向DN 848 527 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 该途径中的所有SZGR 2.0基因
BENPORATH CYCLING GENES 648 385 该途径中的所有SZGR 2.0基因
Stark前额叶皮层22Q11删除 195 138 该途径中的所有SZGR 2.0基因
BYSTRYKH造血干细胞QTL Trans 882 572 该途径中的所有SZGR 2.0基因
CUI TCF21 TARGETS 2 DN 830 547 该途径中的所有SZGR 2.0基因
惠特菲尔德细胞周期S 162 86 该途径中的所有SZGR 2.0基因
STAMBOLSKY TARGETS OF MUTATED TP53 UP 49 35 该途径中的所有SZGR 2.0基因
GABRIELY MIR21 TARGETS 289 187 该途径中的所有SZGR 2.0基因
Johnstone Parvb目标3 DN 918 550 该途径中的所有SZGR 2.0基因
LINSLEY MIR16 TARGETS 206 127 该途径中的所有SZGR 2.0基因
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 106 77 该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS DN 784 464 该途径中的所有SZGR 2.0基因
RATTENBACHER BOUND BY CELF1 467 251 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR开始 UTR end Match method
mir-10 2407 2413 1A HSA-MIR-10A uacccuguagauccgaauuugug
HSA-MIR-10B UACCCUGUAGAACCGAAUUUGU
mir-122 2868 2874 m8 hsa-miR-122a UGGAGUGUGACAAUGGUGUUUGU
miR-129-5p 2763 2769 1A hsa-miR-129脑 CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
mir-17-5p/20/93.mr/106/519.D 65 71 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
HSA-MIR-20A脑 uaaagugcuuauagugcagguag
HSA-MIR-106A aaaagugcuuacugugcagguagc
HSA-MIR-106BSZ uaaagugcugacagugcagau
HSA-MIR-20BSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
HSA-MIR-20A脑 uaaagugcuuauagugcagguag
HSA-MIR-106A aaaagugcuuacugugcagguagc
HSA-MIR-106BSZ uaaagugcugacagugcagau
HSA-MIR-20BSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
mir-186 522 529 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
mir - 223 346 352 1A HSA-MIR-223 UGUCAGUUUGUCAAAUACCCC
miR-23 2686 2692 1A hsa-miR-23a脑 aucacauugccagggauucc
hsa-miR-23b脑 AUCACAUUGCCAGGGAUUACC
miR-26 208 214 1A hsa-miR-26a脑 Uucaaguaauccaggauaggc
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-335 128 134 1A HSA-MIR-335脑 UCAAGAGCAAUAACGAAAAAUGU
miR-539 124 130 m8 HSA-MIR-539 ggagaauuauccuuggugugu