基因页：GIPC1
概括?
| GeneID | 10755 |
| Symbol | GIPC1 |
| 同义词 | C19orf3 | GIPC | Glut1cbp | HS.6454 | IIP-1 | NIP | RGS19IP1 | SEMCAP | SEMCAP | SYTECTIIN | SYTECTIN | TIP-2 |
| 描述 | GIPC PDZ域包含家庭成员1 |
| 参考 | MIM：605072|HGNC:HGNC:1226|ENSEMBL：ENSG00000123159|HPRD:05462|Vega：Otthumg00000182248 |
| Gene type | protein-coding |
| 地图位置 | 19p13.1 |
| Pascal P值 | 0.019 |
| Sherlock P值 | 0.731 |
| Fetal beta | -1.127 |
| eGene | 迈尔斯的顺式和跨性别 |
| 支持 | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS g2cdb.humanpsd G2CDB.HUMANPSP Potential synaptic genes |
数据源中的基因
| Gene set name | 基因组方法 | 描述 | Info |
|---|---|---|---|
| 简历：PGCNP | 全基因组协会研究 | GWAS | |
| PMID:cooccur | 高通量文献搜索 | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| 文学 | 高通量文献搜索 | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 | Click to show details |
| go_annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 7 | |
| 网络 | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | PPI网络中最短路径的贡献：0.7595 |
第一节遗传学和表观遗传学注释
EQTL注释
EQTL注释| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | PVALUE | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| RS7729934 | chr5 | 136104636 | GIPC1 | 10755 | 0.18 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Devlopment期间的基因表达（BrainCloud）
脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
大脑区域没有共表达基因
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005102 | 受体结合 | 新闻学会 | Neurotransmitter (GO term level: 4) | 15459234 |
| 去：0003779 | 肌动蛋白结合 | IEA | - | |
| GO:0017022 | 肌球蛋白结合 | IEA | - | |
| GO:0042803 | protein homodimerization activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0007268 | 突触传输 | IEA | neuron, Synap, Neurotransmitter (GO term level: 6) | - |
| GO:0014047 | 谷氨酸分泌 | IEA | glutamate, Neurotransmitter (GO term level: 7) | - |
| GO:0048167 | regulation of synaptic plasticity | IEA | Synap (GO term level: 8) | - |
| 去：0007186 | G-protein coupled receptor protein signaling pathway | NAS | 9770488 | |
| GO:0006605 | protein targeting | IEA | - | |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | ISS | - | |
| GO：0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | ISS | - | |
| GO:0031647 | 蛋白质稳定性调节 | ISS | - | |
| GO：0043542 | endothelial cell migration | IEA | - | |
| 细胞分量 | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0008021 | 突触囊泡 | IEA | Synap, Neurotransmitter (GO term level: 12) | - |
| 去：0043198 | dendritic shaft | IEA | 树突（GO期限：7） | - |
| GO：0043197 | 树突状脊柱 | IEA | 突触，树突（GO期限：7） | - |
| GO：0012506 | 囊泡膜 | IEA | - | |
| 去：0005829 | cytosol | ISS | - | |
| GO:0005624 | 膜分数 | 艾达 | 9770488 | |
| GO:0005625 | 可溶性部分 | 艾达 | 9770488 | |
| GO:0005737 | 细胞质 | IEA | - | |
| GO:0016020 | 膜 | ISS | - | |
| GO:0016023 | 细胞质ic membrane-bounded vesicle | 艾达 | 12857860 | |
| 去：0005938 | cell cortex | 艾达 | 12857860 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| ACTN1 | FLJ40884 | actinin, alpha 1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10198040 |
| ADRB1 | ADRB1R |b1ar |beta1ar |Rhr | 肾上腺素能，β-1-受体 | Affinity Capture-Western 两个杂交 |
BioGRID | 12724327 |
| ADRB1 | ADRB1R |b1ar |beta1ar |Rhr | 肾上腺素能，β-1-受体 | The carboxy terminus of beta-1-AR interacts with GIPC. | BIND | 12724327 |
| CD93 | C1QR1 |C1QR（P）|C1QRP |CDW93 |mxra4 |DJ737E23.1 | CD93分子 | CD93与GIPC相互作用。 | BIND | 15459234 |
| CD93 | C1QR1 |C1QR（P）|C1QRP |CDW93 |mxra4 |DJ737E23.1 | CD93分子 | GIPC与CD93相互作用。这种相互作用是基于未指定物种与人CD93的GIPC之间的相互作用进行建模的。 | BIND | 15819698 |
| DRD3 | D3DR | ETM1 | FET1 | MGC149204 | MGC149205 | dopamine receptor D3 | 两个杂交 | BioGRID | 14499480 |
| 双子座4 | DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97 | 宝石（核管细胞器）相关蛋白4 | 亲和力捕获ms | BioGRID | 17353931 |
| ITGA5 | CD49e | FNRA | VLA5A | 整合素，α5（纤连蛋白受体，α多肽） | - | HPRD，Biogrid | 11479315 |
| ITGA6 | CD49F |DKFZP686J01244 |FLJ18737 |itga6b |VLA-6 | 整合素，alpha 6 | - | HPRD，Biogrid | 11479315 |
| kif1b | CMT2 | CMT2A | CMT2A1 | FLJ23699 | HMSNII | KIAA0591 | KIAA1448 | KLP | MGC134844 | kinesin family member 1B | - | HPRD，Biogrid | 10198040 |
| LHCGR | FLJ41504 | LCGR | LGR2 | LH/CG-R | LH/CGR | LHR | LHRHR | LSH-R | 黄体生成激素/绒毛膜胶质激素受体 | Affinity Capture-Western Reconstituted Complex 两个杂交 |
BioGRID | 14507927 |
| LHCGR | FLJ41504 | LCGR | LGR2 | LH/CG-R | LH/CGR | LHR | LHRHR | LSH-R | 黄体生成激素/绒毛膜胶质激素受体 | GIPC与HLHR相互作用。 | BIND | 14507927 |
| LRP1 | A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5 | 低密度脂蛋白相关蛋白1（Alpha-2-巨球蛋白受体） | Reconstituted Complex 两个杂交 |
BioGRID | 10827173 |
| LRP2 | DBS | gp330 | low density lipoprotein-related protein 2 | - | HPRD，Biogrid | 11912251 |
| LRP8 | APOER2 | HSZ75190 | MCI1 | 低密度脂蛋白受体相关蛋白8，载脂蛋白E受体 | 两个杂交 | BioGRID | 10827173 |
| 火星 | FLJ35667 | METRS | MTRNS | 甲二烯基-TRNA合成酶 | 亲和力捕获ms | BioGRID | 17353931 |
| MCM7 | CDABP0042 |cdc47 |MCM2 |P1.1-MCM3 |P1CDC47 |p85mcm |PNAS-146 | 微型鲜体维护复杂组件7 | 亲和力捕获ms | BioGRID | 17353931 |
| MMS19 | FLJ34167 | FLJ95146 | MET18 | MGC99604 | MMS19L | hMMS19 | MMS19 nucleotide excision repair homolog (S. cerevisiae) | 亲和力捕获ms | BioGRID | 17353931 |
| MYO1C | FLJ23903 |mmi-beta |mmib |NMI |myr2 | 肌球蛋白IC | 亲和力捕获ms | BioGRID | 17353931 |
| MYO6 | DFNA22 |DFNB37 |KIAA0389 | myosin VI | - | HPRD | 12857860|12893809 |
| MYO6 | DFNA22 |DFNB37 |KIAA0389 | myosin VI | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 12857860|17353931 |
| NTRK1 | DKFZP781I14186 |MTC |trk |trk1 |trka |p140-trka | neurotrophic tyrosine kinase, receptor, type 1 | GIPC interacts with TRKA. This interaction was modelled on a demonstrated interaction between mouse GIPC and rat TrkA. | BIND | 11251075 |
| NTRK1 | DKFZP781I14186 |MTC |trk |trk1 |trka |p140-trka | neurotrophic tyrosine kinase, receptor, type 1 | - | HPRD，Biogrid | 11251075 |
| NTRK2 | GP145-TrkB | TRKB | neurotrophic tyrosine kinase, receptor, type 2 | - | HPRD，Biogrid | 11251075 |
| NUP93 | KIAA0095 | MGC21106 | nucleoporin 93kDa | 亲和力捕获ms | BioGRID | 17353931 |
| PDXDC1 | KIAA0251 | LP8165 | 吡啶还毒素依赖性脱羧酶结构域，含有1个 | 亲和力捕获ms | BioGRID | 17353931 |
| RGS1 | 1R20 | BL34 | IER1 | IR20 | G蛋白信号传导的调节剂1 | - | HPRD | 11251075 |
| RGS19 | GAIP | RGSGAIP | G蛋白信号传导的调节剂19 | GAIP interacts with GIPC. This interaction was modelled on a demonstrated interaction between human GAIP and mouse GIPC. | BIND | 11251075 |
| RGS19 | GAIP | RGSGAIP | G蛋白信号传导的调节剂19 | - | HPRD，Biogrid | 9770488|11251075 |11956658 |
| SDC4 | MGC22217 | SYND4 | syndecan 4 | Affinity Capture-Western | BioGRID | 10911369 |
| SEMA4C | FLJ20369 | KIAA1739 | M-SEMA-F | MGC126382 | MGC126383 | SEMACL1 | SEMAF | SEMAI | SEMA结构域，免疫球蛋白结构域（IG），跨膜结构域（TM）和短细胞质结构域，（Semaphorin）4C | in vitro 体内 |
BioGRID | 10318831 |
| SH3BP4 | BOG25 | TTP | SH3-domain binding protein 4 | 亲和力捕获ms | BioGRID | 17353931 |
| SLC2A1 | DYT17 | DYT18 | GLUT | GLUT1 | MGC141895 | MGC141896 | PED | 溶质载体家族2（促进葡萄糖转运蛋白），成员1 | - | HPRD，Biogrid | 10198040 |
| tagln | DKFZP686P11128 |SM22 |SMCC |tagln1 |WS3-10 | 跨胶结素 | 亲和力捕获ms | BioGRID | 17353931 |
| TPBG | 5T4 |5t4-ag |M6P1 | trophoblast glycoprotein | - | HPRD，Biogrid | 11798178 |
| TYRP1 | CAS2 | CATB | GP75 | TRP | TYRP | b-PROTEIN | tyrosinase-related protein 1 | - | HPRD，Biogrid | 11441007 |
| ZFPM1 | 雾|fog1 |Znf408 |Znf89a | 锌指蛋白，muttonpe 1 | - | HPRD，Biogrid | 15231747 |
V.途径注释
| Pathway name | Pathway size | ＃szgr 2.0基因 | Info |
|---|---|---|---|
| PID SYNDECAN 4通道 | 32 | 25 | 该途径中的所有SZGR 2.0基因 |
| PID TRKR途径 | 62 | 48 | 该途径中的所有SZGR 2.0基因 |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP | 157 | 104 | 该途径中的所有SZGR 2.0基因 |
| Wamunyokoli卵巢癌LMP | 265 | 158 | 该途径中的所有SZGR 2.0基因 |
| CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN | 153 | 100 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | 该途径中的所有SZGR 2.0基因 |
| Nuytten Nipp1靶向DN | 848 | 527 | 该途径中的所有SZGR 2.0基因 |
| CAFFAREL RESPONSE TO THC DN | 31 | 23 | 该途径中的所有SZGR 2.0基因 |
| Caffarel对THC 24小时3 DN的响应 | 13 | 8 | 该途径中的所有SZGR 2.0基因 |
| 里克曼肿瘤分化了井和DN不良 | 382 | 224 | 该途径中的所有SZGR 2.0基因 |
| RICKMAN METASTASIS DN | 261 | 155 | 该途径中的所有SZGR 2.0基因 |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | 该途径中的所有SZGR 2.0基因 |
| LIN APC目标 | 77 | 55 | 该途径中的所有SZGR 2.0基因 |
| BYSTRYKH造血干细胞QTL Trans | 882 | 572 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML FAB MARKERS | 191 | 131 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE UP | 1691年 | 1088 | 该途径中的所有SZGR 2.0基因 |
| LU AGING BRAIN UP | 262 | 186 | 该途径中的所有SZGR 2.0基因 |
| SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | 该途径中的所有SZGR 2.0基因 |
| Yoshimura mapk8靶向 | 1305 | 895 | 该途径中的所有SZGR 2.0基因 |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | 该途径中的所有SZGR 2.0基因 |
| LIM MAMMARY STEM CELL DN | 428 | 246 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
| miRNA family | 目标位置 | mirna id | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| Let-7/98 | 230 | 237 | 1A,m8 | HSA-LET-7A脑 | UGAGGUAGUAGGUUGUAUAGUU |
| HSA-LET-7B脑 | UGAGGUAGUAGGUUGUGUGGUU | ||||
| HSA-LET-7C脑 | ugagguaguagguuguaugguu | ||||
| HSA-LET-7D脑 | agagguaguagguugcauagu | ||||
| HSA-LET-7E脑 | UGAGGUAGGAGGUUGUAUAGU | ||||
| HSA-LET-7F脑 | ugagguagauuguauauaguu | ||||
| HSA-MIR-98脑 | UGAGGUAGUAAGUUGUAUUGUU | ||||
| HSA-LET-7GSZ | ugagguaguuguuguacagu | ||||
| HSA-LET-7I脑 | UGAGGUAGUAGUUUGUGCUGU | ||||
| mir-194 | 481 | 487 | m8 | hsa-miR-194 | UGUAACAGCAACUCCAUGUGGA |
| mir-491 | 223 | 229 | m8 | hsa-miR-491脑 | aguggggaacccuuccaugga |