Gene Page:AHCYL1

Summary?
GeneID 10768
Symbol AHCYL1
Synonyms DCAL|IRBIT|PPP1R78|PRO0233|XPVKONA
Description adenosylhomocysteinase like 1
Reference MIM:607826|HGNC:HGNC:344|Ensembl:ENSG00000168710|HPRD:07613|Vega:OTTHUMG00000011652
Gene type protein-coding
Map location 1p13.2
Pascal p-value 0.039
Sherlock p-value 0.53
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.0235

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconceptionweeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SMC4 0.92 0.81
FBXO5 0.91 0.83
PLK4 0.91 0.80
SGOL2 0.90 0.83
KNTC1 0.90 0.81
ERCC6L 0.90 0.74
CHEK1 0.89 0.79
C11orf82 0.89 0.81
FANCI 0.89 0.76
TTK 0.89 0.79
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HLA-F -0.55 -0.74
MT-CO2 -0.55 -0.80
AIFM3 -0.54 -0.75
AF347015.33 -0.54 -0.80
AF347015.31 -0.54 -0.78
AF347015.27 -0.54 -0.78
MT-CYB -0.54 -0.81
SLC9A3R2 -0.53 -0.62
AF347015.15 -0.53 -0.81
TINAGL1 -0.53 -0.74

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003824 catalytic activity IEA -
GO:0004013 adenosylhomocysteinase activity IEA -
GO:0005488 binding IEA -
GO:0016787 hydrolase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008152 metabolic process IEA -
GO:0006730 one-carbon compound metabolic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005783 endoplasmic reticulum IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYSTEINE AND METHIONINE METABOLISM 34 24 All SZGR 2.0 genes in this pathway
KEGG SELENOAMINO ACID METABOLISM 26 18 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP 108 67 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164 122 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 108 74 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS UP 35 25 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 121 79 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP 89 51 All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191 131 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN 150 93 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
NICK RESPONSE TO PROC TREATMENT DN 27 18 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
OKAMOTO LIVER CANCER MULTICENTRIC OCCURRENCE UP 25 15 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 362 368 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-135 1884 1890 m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-137 2023 2029 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-143 129 136 1A,m8 hsa-miR-143brain UGAGAUGAAGCACUGUAGCUCA
miR-182 1579 1586 1A,m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-24 953 959 1A hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367 2000 2006 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-320 1382 1388 1A hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-33 1998 2004 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-496 1888 1894 m8 hsa-miR-496 AUUACAUGGCCAAUCUC
miR-96 1580 1586 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC